10th Anniversary Collection

Since its launch in 2000, Genome Biology has become a premier journal for genomics research. We are celebrating our success over the last ten years with a series of exciting reviews and special content that mark key developments in the genomics field over this period.

GWASs and the age of human as the model organism for autoimmune genetic research

Genetic studies have identified more than 150 autoimmune loci, and next-generation sequencing will identify more. Is it time to make human the model organism for autoimmune research?

Authors: Robert Plenge

Citation: Genome Biology 2010 11:212

Content type: Review Published on: 5 May 2010
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Cancer genomics identifies determinants of tumor biology

Unbiased sequencing and analysis of human tumors is revealing unsuspected somatic changes that, upon further study, are elucidating aspects of tumor biology and identifying new biomarkers.

Authors: Elaine R Mardis

Citation: Genome Biology 2010 11:211

Content type: Review Published on: 5 May 2010
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Direct sequencing of the human microbiome readily reveals community differences

Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to stu...

Authors: Justin Kuczynski, Elizabeth K Costello, Diana R Nemergut, Jesse Zaneveld, Christian L Lauber, Dan Knights, Omry Koren, Noah Fierer, Scott T Kelley, Ruth E Ley, Jeffrey I Gordon and Rob Knight

Citation: Genome Biology 2010 11:210

Content type: Review Published on: 5 May 2010
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The origin and early evolution of eukaryotes in the light of phylogenomics

Phylogenomics of eukaryote supergroups suggest a highly complex last common ancestor of eukaryotes and a key role of mitochondrial endosymbiosis in the origin of eukaryotes.

Authors: Eugene V Koonin

Citation: Genome Biology 2010 11:209

Content type: Review Published on: 5 May 2010
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The next frontier of systems biology: higher-order and interspecies interactions

Systems approaches are not so different in essence from classical genetic and biochemical approaches, and in the future may become adopted so widely that the term 'systems biology' itself will become obsolete.

Authors: Michael A Fischbach and Nevan J Krogan

Citation: Genome Biology 2010 11:208

Content type: Review Published on: 5 May 2010
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The case for cloud computing in genome informatics

With DNA sequencing now getting cheaper more quickly than data storage or computation, the time may have come for genome informatics to migrate to the cloud.

Authors: Lincoln D Stein

Citation: Genome Biology 2010 11:207

Content type: Review Published on: 5 May 2010
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Between a chicken and a grape: estimating the number of human genes

Many people expected the question 'How many genes in the human genome?' to be resolved with the publication of the genome sequence in 2001, but estimates continue to fluctuate.

Authors: Mihaela Pertea and Steven L Salzberg

Citation: Genome Biology 2010 11:206

Content type: Review Published on: 5 May 2010
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And they said it wouldn't last...

Authors: Gregory A Petsko

Citation: Genome Biology 2010 11:121

Content type: Comment Published on: 5 May 2010
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A decade and genome of change

Innovations in genomic technologies have generated huge advances in biomedical research over the last decade.

Authors: Clare Garvey

Citation: Genome Biology 2010 11:120

Content type: Editorial Published on: 5 May 2010
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