Skip to main content

Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

Page 1 of 10

  1. In the absence of PCR detection of SARS-CoV-2 RNA, accurate diagnosis of COVID-19 is challenging. Low-dose computed tomography (CT) detects pulmonary infiltrates with high sensitivity, but findings may be non-...

    Authors: Jochen Schneider, Hrvoje Mijočević, Kurt Ulm, Bernhard Ulm, Simon Weidlich, Silvia Würstle, Kathrin Rothe, Matthias Treiber, Roman Iakoubov, Ulrich Mayr, Tobias Lahmer, Sebastian Rasch, Alexander Herner, Egon Burian, Fabian Lohöfer, Rickmer Braren…

    Citation: Respiratory Research 2021 22:119

    Content type: Research

    Published on:

  2. The COVID-19 pandemic has affected how clinical trials are managed, both within existing portfolios and for the rapidly developed COVID-19 trials. Sponsors or delegated organisations responsible for monitoring...

    Authors: Sharon B. Love, Emma Armstrong, Carrie Bayliss, Melanie Boulter, Lisa Fox, Joanne Grumett, Patricia Rafferty, Barbara Temesi, Krista Wills and Andrea Corkhill

    Citation: Trials 2021 22:279

    Content type: Research

    Published on:

  3. Health innovations are generally oriented on a techno-economic vision. In this perspective, technologies are seen as an end in themselves, and there is no arrangement between the technical and the social value...

    Authors: Marietou Niang, Sophie Dupéré, Hassane Alami and Marie-Pierre Gagnon

    Citation: Globalization and Health 2021 17:46

    Content type: Debate

    Published on:

  4. The aim of our study was to determine through a systematic review and meta-analysis the incubation period of COVID-19. It was conducted based on the preferred reporting items for systematic reviews and meta-an...

    Authors: Wafa Dhouib, Jihen Maatoug, Imen Ayouni, Nawel Zammit, Rim Ghammem, Sihem Ben Fredj and Hassen Ghannem

    Citation: Systematic Reviews 2021 10:101

    Content type: Systematic review update

    Published on:

  5. The ongoing pandemic of coronavirus disease 2019 (COVID-19) has the potential to reverse progress towards global targets. This study examines the risks that the COVID-19 pandemic poses to equitable access to e...

    Authors: Floriano Amimo, Ben Lambert, Anthony Magit and Masahiro Hashizume

    Citation: Globalization and Health 2021 17:42

    Content type: Review

    Published on:

  6. Medicinal plants are the fundamental unit of traditional medicine system in Nepal. Nepalese people are rich in traditional medicine especially in folk medicine (ethnomedicine), and this system is gaining much ...

    Authors: Dipak Khadka, Man Kumar Dhamala, Feifei Li, Prakash Chandra Aryal, Pappu Rana Magar, Sijar Bhatta, Manju Shree Thakur, Anup Basnet, Dafang Cui and Shi Shi

    Citation: Journal of Ethnobiology and Ethnomedicine 2021 17:26

    Content type: Research

    Published on:

  7. COVID-19 pneumonia has been associated with severe acute hypoxia, sepsis-like states, thrombosis and chronic sequelae including persisting hypoxia and fibrosis. The molecular hypoxia response pathway has been ...

    Authors: Atish Gheware, Dhwani Dholakia, Sadasivam Kannan, Lipsa Panda, Ritu Rani, Bijay Ranjan Pattnaik, Vaibhav Jain, Yash Parekh, M. Ghalib Enayathullah, Kiran Kumar Bokara, Venkatesan Subramanian, Mitali Mukerji, Anurag Agrawal and Bhavana Prasher

    Citation: Respiratory Research 2021 22:99

    Content type: Research

    Published on:

  8. Very few studies have been concerned with assessing the prevalence of burnout and depressive symptoms, especially during an infectious outbreak on non-frontline health care workers, such as a psychiatrist. In ...

    Authors: Abdulmajeed A. Alkhamees, Hatem Assiri, Hatim Yousef Alharbi, Abdullah Nasser and Mohammad A. Alkhamees

    Citation: Human Resources for Health 2021 19:46

    Content type: Research

    Published on:

  9. Italy was the first European country to implement a national lockdown because of the COVID-19 pandemic. Worldwide, this pandemic had a huge impact on the mental health of people in many countries causing simil...

    Authors: Leonardo Villani, Roberta Pastorino, Enrico Molinari, Franco Anelli, Walter Ricciardi, Guendalina Graffigna and Stefania Boccia

    Citation: Globalization and Health 2021 17:39

    Content type: Research

    Published on:

  10. At the height of the COVID-19 pandemic, Thailand had almost depleted its critical care resources, particularly intensive care unit (ICU) beds and ventilators. This prompted the necessity to develop a national ...

    Authors: Aniqa Islam Marshall, Rachel Archer, Woranan Witthayapipopsakul, Kanchanok Sirison, Somtanuek Chotchoungchatchai, Pisit Sriakkpokin, Orapan Srisookwatana, Yot Teerawattananon and Viroj Tangcharoensathien

    Citation: Health Research Policy and Systems 2021 19:47

    Content type: Research

    Published on:

  11. The global health agenda is ill-defined as an analytical construct, complicating attempts by scholars and proponents to make claims about the agenda status of issues. We draw on Kingdon’s definition of the age...

    Authors: Stephanie L. Smith, Jeremy Shiffman, Yusra Ribhi Shawar and Zubin Cyrus Shroff

    Citation: Globalization and Health 2021 17:33

    Content type: Research

    Published on:

  12. The pandemic of this century has overwhelmed the healthcare systems of affected countries, and all resources have been diverted to coronavirus disease 2019. At the onset, coronavirus disease 2019 can present a...

    Authors: Abdullah Isneen Hilmy, Rajib Kumar Dey, Hisham Ahmed Imad, Abdul Azeez Yoosuf, Ali Nazeem and Ali Abdulla Latheef

    Citation: Journal of Medical Case Reports 2021 15:171

    Content type: Case report

    Published on:

  13. Increased anxiety was frequently reported during the 2020 global COVID-19 pandemic. An association between anxiety and increased body weight has been documented. Identifying associations between diet quality a...

    Authors: Vered Kaufman-Shriqui, Daniela Abigail Navarro, Olga Raz and Mona Boaz

    Citation: Israel Journal of Health Policy Research 2021 10:28

    Content type: Original research article

    Published on:

  14. Post-exposure prophylaxis (PEP) is a well-established strategy for the prevention of infectious diseases, in which recently exposed people take a short course of medication to prevent infection. The primary ob...

    Authors: Darrell H. S. Tan, Adrienne K. Chan, Peter Jüni, George Tomlinson, Nick Daneman, Sharon Walmsley, Matthew Muller, Rob Fowler, Srinivas Murthy, Natasha Press, Curtis Cooper, Todd Lee, Tony Mazzulli and Allison McGeer

    Citation: Trials 2021 22:224

    Content type: Study protocol

    Published on:

  15. A significant portion of critically ill patients with coronavirus disease 2019 (COVID-19) are at high risk of developing intensive care unit (ICU)-acquired swallowing dysfunction (neurogenic dysphagia) as a co...

    Authors: Marianna Traugott, Wolfgang Hoepler, Reinhard Kitzberger, Sophie Pavlata, Tamara Seitz, Sebastian Baumgartner, Gudrun Placher-Sorko, Daniela Pirker-Krassnig, Urs Ehehalt, Andreas Grasnek, Michaela Beham-Kacerovsky, Emanuela Friese, Christoph Wenisch and Stephanie Neuhold

    Citation: Journal of Medical Case Reports 2021 15:148

    Content type: Case report

    Published on:

  16. More than 210,000 medical workers have fought against the outbreak of Coronavirus Disease 2019 (COVID-19) in Hubei in China since December 2019. However, the prevalence of mental health problems in frontline m...

    Authors: Wen-Ping Guo, Qing Min, Wei-Wei Gu, Liang Yu, Xiao Xiao, Wei-Bing Yi, Hong-Liang Li, Bei Huang, Jun-Li Li, Ya-Jun Dai, Jian Xia, Jie Liu, Bei Li, Ben-Hong Zhou, Minglun Li, Hong-Xi Xu…

    Citation: Health and Quality of Life Outcomes 2021 19:103

    Content type: Research

    Published on:

  17. The impact of general population lockdown implemented in the face of the COVID-19 epidemic needs to be evaluated. We describe here a longitudinal study on the mental health of adults in France.

    Authors: Leila Ramiz, Benjamin Contrand, Madelyn Yiseth Rojas Castro, Marion Dupuy, Li Lu, Catherine Sztal-Kutas and Emmanuel Lagarde

    Citation: Globalization and Health 2021 17:29

    Content type: Research

    Published on:

  18. There are limited data on cardiovascular complications of coronavirus disease 2019 in pregnancy, and there are only a few case reports on coronavirus disease 2019 related cardiomyopathy in pregnancy. Different...

    Authors: Rahim Nejadrahim, Sara Khademolhosseini, Hadiseh Kavandi and Reza Hajizadeh

    Citation: Journal of Medical Case Reports 2021 15:143

    Content type: Case report

    Published on:

  19. COVID-19 lockdowns may lead to physical inactivity, a major risk factor for non-communicable diseases. This study aims to determine: 1) the trajectory in daily step counts before, during and after the lockdown...

    Authors: Ding Ding, Minna Cheng, Borja del Pozo Cruz, Tao Lin, Shuangyuan Sun, Li Zhang, Qinping Yang, Zhicong Ma, Jing Wang, Yingnan Jia and Yan Shi

    Citation: International Journal of Behavioral Nutrition and Physical Activity 2021 18:40

    Content type: Research

    Published on:

  20. Three months after the first reported cases, COVID-19 had spread to nearly 90% of World Health Organization (WHO) member states and only 24 countries had not reported cases as of 30 March 2020. This analysis a...

    Authors: Zheng Li, Cynthia Jones, Girum S. Ejigu, Nisha George, Amanda L. Geller, Gregory C. Chang, Alys Adamski, Ledor S. Igboh, Rebecca D. Merrill, Philip Ricks, Sara A. Mirza and Michael Lynch

    Citation: Globalization and Health 2021 17:28

    Content type: Research

    Published on:

  21. Even when resting pulse oximetry is normal in the patient with acute Covid-19, hypoxia can manifest on exertion. We summarise the literature on the performance of different rapid tests for exertional desaturat...

    Authors: Asli Kalin, Babak Javid, Matthew Knight, Matt Inada-Kim and Trisha Greenhalgh

    Citation: Systematic Reviews 2021 10:77

    Content type: Research

    Published on:

  22. The coronavirus disease 2019 (COVID-19) pandemic has caused recurring and major outbreaks in multiple human populations around the world. The plethora of clinical presentations of severe acute respiratory synd...

    Authors: Rosemond Qian-Xiu Tan, Wai Tak Victor Li, Wing-Zi Shum, Sheung Chit Chu, Hang-Long Li, Yat-Fung Shea and Tom Wai-Hin Chung

    Citation: Systematic Reviews 2021 10:73

    Content type: Protocol

    Published on:

  23. The COVID-19 pandemic has remarkably altered community mental health service delivery through the rapid implementation of telehealth. This study reports provider perspectives on the impact that COVID-19 and th...

    Authors: Marisa Sklar, Kendal Reeder, Kristine Carandang, Mark G. Ehrhart and Gregory A. Aarons

    Citation: Implementation Science Communications 2021 2:29

    Content type: Short report

    Published on:

  24. Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages...

    Authors: Benjamin Gaborit, Bernard Vanhove, Marie-Anne Vibet, Aurélie Le Thuaut, Karine Lacombe, Vincent Dubee, Florence Ader, Virginie Ferre, Eric Vicaut, Jéremie Orain, Morgane Le Bras, Anne Omnes, Laetitia Berly, Alexandra Jobert, Pascale Morineau-Le Houssine, Karine Botturi…

    Citation: Trials 2021 22:199

    Content type: Study protocol

    Published on:

  25. Patient and Public Involvement (PPI) describes the active involvement of patients and the public in the research process. Through PPI, patients and members of the public are increasingly involved in the design...

    Authors: Zahra Jamal, Alexander Perkins, Christopher Allen, Richard Evans, Joanna Sturgess, Claire Snowdon, Tim Clayton and Diana Elbourne

    Citation: Research Involvement and Engagement 2021 7:13

    Content type: Research article

    Published on:

  26. Emerging literature on the current COVID-19 crisis suggests that children may experience increased anxiety and depression as a result of the pandemic. To prevent such school and mental health-related problems,...

    Authors: Catherine Malboeuf-Hurtubise, Terra Léger-Goodes, Geneviève A. Mageau, Geneviève Taylor, Catherine M. Herba, Nicholas Chadi and David Lefrançois

    Citation: Child and Adolescent Psychiatry and Mental Health 2021 15:15

    Content type: Research article

    Published on:

  27. To assess the registration quality of traditional Chinese medicine (TCM) clinical trials for COVID-19, H1N1, and SARS.

    Authors: Zhuoran Kuang, Xiaoyan Li, Jianxiong Cai, Yaolong Chen, Xiaoyuan Qiu and Xiaojia Ni

    Citation: Trials 2021 22:188

    Content type: Research

    Published on:

    The Correction to this article has been published in Trials 2021 22:259

  28. The outbreak of SARS-CoV-2 (coronavirus, COVID-19), declared a pandemic by the World Health Organization (WHO), is a global health problem with ever-increasing attributed deaths. Vital sign trends are routinel...

    Authors: Fahad Mujtaba Iqbal, Meera Joshi, Gary Davies, Sadia Khan, Hutan Ashrafian and Ara Darzi

    Citation: Pilot and Feasibility Studies 2021 7:62

    Content type: Study Protocol

    Published on:

  29. Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T ...

    Authors: Alberto Ricci, Alessandra Pagliuca, Michela D’Ascanio, Marta Innammorato, Claudia De Vitis, Rita Mancini, Simonetta Giovagnoli, Francesco Facchiano, Bruno Sposato, Paolo Anibaldi, Adriano Marcolongo, Chiara De Dominicis, Andrea Laghi, Emanuele Muscogiuri and Salvatore Sciacchitano

    Citation: Respiratory Research 2021 22:76

    Content type: Research

    Published on:

  30. The COVID-19 pandemic has necessitated unprecedented changes in the way that services are delivered to individuals experiencing homelessness and problem substance use. Protecting those at high risk of infectio...

    Authors: Tessa Parkes, Hannah Carver, Wendy Masterton, Danilo Falzon, Josh Dumbrell, Susan Grant and Iain Wilson

    Citation: Harm Reduction Journal 2021 18:26

    Content type: Research

    Published on:

  31. The COVID-19 pandemic is a biosecurity threat, and many resource-rich countries are stockpiling and/or making plans to secure supplies of vaccine, therapeutics, and diagnostics for their citizens. We review th...

    Authors: Bisi Bright, Chinedum Peace Babalola, Nadia Adjoa Sam-Agudu, Augustine Anayochukwu Onyeaghala, Adebola Olatunji, Ufuoma Aduh, Patrick O. Sobande, Trevor A. Crowell, Yenew Kebede Tebeje, Sunny Phillip, Nicaise Ndembi and Morenike Oluwatoyin Folayan

    Citation: Globalization and Health 2021 17:24

    Content type: Review

    Published on:

  32. Severe acute respiratory syndrome coronavirus 2 infection can lead to a constellation of viral and immune symptoms called coronavirus disease 2019. Emerging literature increasingly supports the premise that se...

    Authors: Artem Minalyan, Franklin L. Thelmo, Vincent Chan, Stephanie Tzarnas and Faizan Ahmed

    Citation: Journal of Medical Case Reports 2021 15:112

    Content type: Case report

    Published on:

  33. The coronavirus-19 (COVID-19) has reached pandemic status and is affecting countries all over the world. The COVID-19 pandemic is accompanied by various stressors that require adjustment in everyday life and p...

    Authors: Noemi Anja Brog, Julia Katharina Hegy, Thomas Berger and Hansjörg Znoj

    Citation: Trials 2021 22:171

    Content type: Study protocol

    Published on:

  34. Pregnancy seems to increase the risk of thrombotic thrombocytopenic purpura (TTP) relapses and make the TTP more severe in any of the pregnancy trimesters, or even during the postpartum period.

    Authors: Soheila Aminimoghaddam, Narjes Afrooz, Setare Nasiri, Ozra Motaghi Nejad and Fatemeh Mahmoudzadeh

    Citation: Journal of Medical Case Reports 2021 15:104

    Content type: Case report

    Published on:

  35. The impact of COVID-19 pandemic on mental health of pregnant and lactating women is unclear. This study aimed to assess the impact of COVID-19 on psychological health, sexual function, and quality of life (QoL...

    Authors: Negin Mirzaei, Shahideh Jahanian Sadatmahalleh, Mahnaz Bahri Khomami, Ashraf Moini and Anoshirvan Kazemnejad

    Citation: Health and Quality of Life Outcomes 2021 19:66

    Content type: Research

    Published on:

  36. As of mid-June 2020, 7,500,000 people were infected with SARS-CoV-2 worldwide and 420,000 people died, mainly from coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). COVID-...

    Authors: Aurélien Mazeraud, Bruno Gonçalves, Philippe Aegerter, Letizia Mancusi, Christine Rieu, Fernando Bozza, Khaoussou Sylla, Shidasp Siami and Tarek Sharshar

    Citation: Trials 2021 22:170

    Content type: Study protocol

    Published on:

  37. Disease outbreak not only carries the risk of death to the public due to the infection, but it also can lead to unbearable psychological impact on the mental health of the individuals. This study aims to explo...

    Authors: Reza Shahriarirad, Amirhossein Erfani, Keivan Ranjbar, Amir Bazrafshan and Alireza Mirahmadizadeh

    Citation: International Journal of Mental Health Systems 2021 15:19

    Content type: Research

    Published on:

  38. We report a high-risk case of a coronavirus disease 19 (COVID-19)-positive patient with comorbidities including diabetes mellitus (DM), hypertension (HTN), hypothyroidism and chronic kidney disease (CKD), trea...

    Authors: Alka Mishra, Sumitra A. Bentur, Sonika Thakral, Rahul Garg and Bhanu Duggal

    Citation: Journal of Medical Case Reports 2021 15:95

    Content type: Case report

    Published on:

  39. In Belgium, confinement measures were introduced on the 13th of March 2020 to curb the spread of the coronavirus disease (COVID-19). These measures may affect health behaviours of the population such as eating...

    Authors: Sabine Drieskens, Nicolas Berger, Stefanie Vandevijvere, Lydia Gisle, Elise Braekman, Rana Charafeddine, Karin De Ridder and Stefaan Demarest

    Citation: Archives of Public Health 2021 79:22

    Content type: Research

    Published on:

  40. The novel coronavirus disease (Covid-19) has spread quickly worldwide with dramatic consequences on our daily lives. Adverse psychosocial consequences of Covid-19 might be particularly severe for children and ...

    Authors: Josefine Rothe, Judith Buse, Anne Uhlmann, Annet Bluschke and Veit Roessner

    Citation: Child and Adolescent Psychiatry and Mental Health 2021 15:11

    Content type: Research article

    Published on:

  41. Very little is known about the risk that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection poses to cancer patients, many of whom are immune compromised causing them to be more susce...

    Authors: D. Madduri, S. Parekh, T. B. Campbell, F. Neumann, F. Petrocca and S. Jagannath

    Citation: Journal of Medical Case Reports 2021 15:90

    Content type: Case report

    Published on:

  42. The sharing of individual participant-level data from COVID-19 trials would allow re-use and secondary analysis that can help accelerate the identification of effective treatments. The sharing of trial data is...

    Authors: Rebecca Li, Megan von Isenburg, Marcia Levenstein, Stan Neumann, Julie Wood and Ida Sim

    Citation: Trials 2021 22:153

    Content type: Research

    Published on:

  43. Coronavirus disease 2019 (COVID-19), the global pandemic that has spread throughout the world, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the limited scientific evidence o...

    Authors: Maryam Rabiei, Tahereh Soori, Amene Abiri, Zohreh Farsi, Arshia Shizarpour and Reihaneh Pirjani

    Citation: Journal of Medical Case Reports 2021 15:87

    Content type: Case report

    Published on:

  44. China and the rest of the world are experiencing an outbreak of the 2019 novel coronavirus disease (COVID-19). Patients with cancer are more susceptible to viral infection and are more likely to develop severe...

    Authors: Zhilan Chen, Chun Zhang, Jiu Yin, Xin Xin, Hemei Li, Yapei Wang, Benjamin K. Tsang and Qinghua Zhang

    Citation: Journal of Ovarian Research 2021 14:35

    Content type: Review

    Published on:

  45. To control the spread of the new SARS-CoV-2 infection's disease (COVID-19), appropriate precautionary behaviors by the public should be promoted. There are international differences in public cognitive and beh...

    Authors: Akihiro Shiina, Tomihisa Niitsu, Osamu Kobori, Keita Idemoto, Tasuku Hashimoto, Tsuyoshi Sasaki, Yoshito Igarashi, Eiji Shimizu, Michiko Nakazato, Kenji Hashimoto and Masaomi Iyo

    Citation: Annals of General Psychiatry 2021 20:13

    Content type: Primary research

    Published on:

  46. The COVID-19 crisis has had profound impacts on health service provision, particularly those providing client facing services. Supervised injecting facilities and drug consumption rooms across the world have b...

    Authors: Amanda Roxburgh, Marianne Jauncey, Carolyn Day, Mark Bartlett, Shelley Cogger, Paul Dietze, Suzanne Nielsen, Julie Latimer and Nico Clark

    Citation: Harm Reduction Journal 2021 18:20

    Content type: Opinion

    Published on:

  47. COVID-19 has spread rapidly around the world, affecting a large percentage of the population. When lifting certain mandatory measures for an economic restart, robust surveillance must be established and implem...

    Authors: Yangyang Sun, Lei Yu, Chengxi Liu, Shanting Ye, Wei Chen, Dechang Li and Weiren Huang

    Citation: Journal of Translational Medicine 2021 19:74

    Content type: Research

    Published on:

  48. Grocery food taxes represent a stable tax revenue stream for state and municipal government during times of adverse economic shocks such as that observed under the coronavirus disease 2019 (COVID-19) pandemic....

    Authors: Lingxiao Wang, Yuqing Zheng, Steven Buck, Diansheng Dong and Harry M. Kaiser

    Citation: Health Economics Review 2021 11:5

    Content type: Research

    Published on:

\