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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. It has been recently hypothesized that infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to fibrotic sequelae in patients recovering from coronavirus disease 2019 (COVID-19). I...

    Authors: Paola Rogliani, Luigino Calzetta, Angelo Coppola, Ermanno Puxeddu, Gianluigi Sergiacomi, Dejanira D’Amato and Antonio Orlacchio

    Citation: Respiratory Research 2020 21:286

    Content type: Letter to the Editor

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  2. Israel ranks very high globally in performing bariatric surgery (BS) per capita. In the first phase of the COVID-19 pandemic the bariatric surgeons’ community faced many concerns and challenges, especially in ...

    Authors: Nahum Beglaibter, Orly Zelekha, Lital Keinan-Boker, Nasser Sakran and Ahmad Mahajna

    Citation: Israel Journal of Health Policy Research 2020 9:59

    Content type: Original research article

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  3. Interleukin-6 (IL-6) was proposed to be associated with the severity of coronavirus disease 2019 (COVID-19). The present study aimed to explore the kinetics of IL-6 levels, validate this association in COVID-1...

    Authors: Jing Zhang, Yiqun Hao, Wuling Ou, Fei Ming, Gai Liang, Yu Qian, Qian Cai, Shuang Dong, Sheng Hu, Weida Wang and Shaozhong Wei

    Citation: Journal of Translational Medicine 2020 18:406

    Content type: Research

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  4. The Covid-19 pandemic is causing changes in delivery of medical care worldwide. It is not known how the management of headache patients was affected by the lockdown during the pandemic. The aim of the present ...

    Authors: Espen Saxhaug Kristoffersen, Kashif Waqar Faiz, Else Charlotte Sandset, Anette Margrethe Storstein, Simon Stefansen, Bendik Slagsvold Winsvold and Jakob Møller Hansen

    Citation: The Journal of Headache and Pain 2020 21:128

    Content type: Research article

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    The Correction to this article has been published in The Journal of Headache and Pain 2020 21:132

  5. The heavy reliance on remote patient care (RPC) during the COVID-19 health crisis may have expedited the emergence of digital health tools that can contribute to safely and effectively moving the locus of care...

    Authors: Shirly Bar-Lev and Dizza Beimel

    Citation: Israel Journal of Health Policy Research 2020 9:58

    Content type: Original research article

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  6. The acknowledgment of the mental health toll of the COVID-19 epidemic in healthcare workers has increased considerably as the disease evolved into a pandemic status. Indeed, high prevalence rates of depression...

    Authors: Luisa Weiner, Fabrice Berna, Nathalie Nourry, François Severac, Pierre Vidailhet and Amaury C. Mengin

    Citation: Trials 2020 21:870

    Content type: Study protocol

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  7. Prior studies reported that 5 ~ 32% COVID-19 patients were critically ill, a situation that poses great challenge for the management of the patients and ICU resources. We aim to identify independent risk facto...

    Authors: Sijing Cheng, Dingfeng Wu, Jie Li, Yifeng Zou, Yunle Wan, Lihan Shen, Lixin Zhu, Mang Shi, Linlin Hou, Tao Xu, Na Jiao, Yichen Li, Yibo Huang, Zhipeng Tang, Mingwei Xu, Shusong Jiang…

    Citation: Respiratory Research 2020 21:277

    Content type: Research

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  8. Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmet...

    Authors: Thomas Sonnweber, Anna Boehm, Sabina Sahanic, Alex Pizzini, Magdalena Aichner, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstätter, David Haschka, Verena Petzer, Richard Hilbe, Markus Theurl, Daniela Lehner, Manfred Nairz, Bernhard Puchner, Anna Luger…

    Citation: Respiratory Research 2020 21:276

    Content type: Research

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  9. The Hadassah Medical Organization operates two hospitals in Jerusalem. During the COVID-19 pandemic it made an administrative decision to operate one hospital as a COVID-19 treatment hospital (CTH) and to have...

    Authors: Yael Milgrom, Yuval Tal and Aharon S. Finestone

    Citation: Israel Journal of Health Policy Research 2020 9:55

    Content type: Short communication

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  10. There is an urgent need for treatments that can shorten hospitalization and lower the risk of secondary infection and death in patients with corona disease. The ProPac-COVID trial evaluates whether combination...

    Authors: Pradeesh Sivapalan, Charlotte Suppli Ulrik, Therese Sophie Lappere, Josefin Viktoria Eklöf, Saher Burhan Shaker, Uffe Christian Steinholtz Bødtger, Andrea Browatzki, Christian Niels Meyer, Ulla Møller Weinreich, Christian B. Laursen, Tor Biering-Sørensen, Filip Krag Knop, Jens D. Lundgren and Jens-Ulrik Stæhr Jensen

    Citation: Trials 2020 21:867

    Content type: Update

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    The Letter to this article has been published in Trials 2020 21:513

  11. The outbreak of a new Coronavirus disease (COVID-19) poses dramatic challenges to public health authorities worldwide. One measure put in place to contain the spread of the disease is self-quarantine of indivi...

    Authors: Moran Bodas and Kobi Peleg

    Citation: Israel Journal of Health Policy Research 2020 9:54

    Content type: Original research article

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  12. Facing the global health crisis of COVID-19, health systems are increasingly supporting the use of telemedicine in ambulatory care settings. It is not clear whether the increased use of telemedicine will persi...

    Authors: Zachi Grossman, Gabriel Chodick, Stephen M. Reingold, Gil Chapnick and Shai Ashkenazi

    Citation: Israel Journal of Health Policy Research 2020 9:53

    Content type: Original research article

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  13. The understanding of coronavirus disease 2019 (COVID-19) is rapidly evolving. Although it is primarily a respiratory illness, other manifestations, such as Guillain-Barré syndrome, immune thrombocytopenia, and...

    Authors: Birgitte Tholin, Marit Teigen Hauge, Pål Aukrust, Lutz Fehrle and Tor Henrik Tvedt

    Citation: Journal of Medical Case Reports 2020 14:187

    Content type: Case report

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  14. COVID-19 which started in Wuhan, China and swiftly expanded geographically worldwide, including to Low to Middle Income Countries (LMICs). This in turn raised numerous ethical concerns in preparedness, knowled...

    Authors: Faouzia Tanveer, Ali Talha Khalil, Muhammad Ali and Zabta Khan Shinwari

    Citation: International Journal for Equity in Health 2020 19:182

    Content type: Review

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  15. Primary objective: To determine the efficacy of a candidate antiviral on time to virological cure compared to standard of care within 14 days of randomisation

    Authors: James H. McMahon, Jillian S. Y. Lau, Janine Roney, Benjamin A. Rogers, Jason Trubiano, Joseph Sasadeusz, James S. Molton, Bradley Gardiner, Sue J. Lee, Jennifer F. Hoy, Allen Cheng and Anton Y. Peleg

    Citation: Trials 2020 21:847

    Content type: Letter

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  16. Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tez...

    Authors: Claire Emson, Sarah Diver, Latifa Chachi, Ayman Megally, Cherrie Small, John Downie, Jane R. Parnes, Karin Bowen, Gene Colice and Chris E. Brightling

    Citation: Respiratory Research 2020 21:265

    Content type: Study protocol

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  17. Headache is the most common COVID-19-related neurological symptom. We aimed to reveal diagnostic clues of headache for COVID-19 infection and to investigate the course of primary headaches during the pandemic.

    Authors: Özge Uygun, Mustafa Ertaş, Esme Ekizoğlu, Hayrunnisa Bolay, Aynur Özge, Elif Kocasoy Orhan, Arif Atahan Çağatay and Betül Baykan

    Citation: The Journal of Headache and Pain 2020 21:121

    Content type: Research article

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  18. The coronavirus disease 2019 (COVID-19) has brought a global disaster. Quantitative lesions may provide the radiological evidence of the severity of pneumonia and further to assess the effect of comorbidity on...

    Authors: Cui Zhang, Guangzhao Yang, Chunxian Cai, Zhihua Xu, Hai Wu, Youmin Guo, Zongyu Xie, Hengfeng Shi, Guohua Cheng and Jian Wang

    Citation: European Journal of Medical Research 2020 25:49

    Content type: Research

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  19. SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two million people in the United States. While many people recover from the virus uneventfully, a s...

    Authors: William R. Hartman, Aaron S. Hess and Joseph P. Connor

    Citation: Translational Medicine Communications 2020 5:17

    Content type: Research

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  20. COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory dis...

    Authors: Stefano Aliberti, Francesco Amati, Maria Pappalettera, Marta Di Pasquale, Alice D’Adda, Marco Mantero, Andrea Gramegna, Edoardo Simonetta, Anna Maria Oneta, Emilia Privitera, Andrea Gori, Giorgio Bozzi, Flora Peyvandi, Francesca Minoia, Giovanni Filocamo, Chiara Abbruzzese…

    Citation: Respiratory Research 2020 21:260

    Content type: Review

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  21. The outbreak of Coronavirus Disease is causing considerable acute risk to public health and might also have an unanticipated impact on the mental health of children and adolescents in the long run. This study ...

    Authors: Shitao Chen, Zeyuan Cheng and Jing Wu

    Citation: Globalization and Health 2020 16:96

    Content type: Research

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  22. Family-based treatment (FBT) is an efficacious outpatient intervention for young people diagnosed with Anorexia Nervosa (AN). To date, treatment to protocol has relied on standard face-to-face delivery. Face-t...

    Authors: A. Hambleton, D. Le Grange, J. Miskovic-Wheatley, S. Touyz, M. Cunich and S. Maguire

    Citation: Journal of Eating Disorders 2020 8:50

    Content type: Study protocol

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  23. Coronavirus Disease 2019 (COVID-19) spread rapidly around the world. We aimed to describe the epidemiological characteristics and the entire evolution of COVID-19 in Wuhan, and to evaluate the effect of non-ph...

    Authors: Dongming Wang, Jing Cai, Tingming Shi, Yang Xiao, Xiaobing Feng, Meng Yang, Wenzhen Li, Wei Liu, Linling Yu, Zi Ye, Tao Xu, Jixuan Ma, Mingyan Li and Weihong Chen

    Citation: Respiratory Research 2020 21:257

    Content type: Research

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  24. The COVID-19 pandemic disrupted the personal, professional and social life of Australians with some people more impacted than others.

    Authors: Muhammad Aziz Rahman, Nazmul Hoque, Sheikh M. Alif, Masudus Salehin, Sheikh Mohammed Shariful Islam, Biswajit Banik, Ahmed Sharif, Nashrin Binte Nazim, Farhana Sultana and Wendy Cross

    Citation: Globalization and Health 2020 16:95

    Content type: Research

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  25. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) outbreak, called coronavirus disease - 2019 (COVID-19), has affected more than 200 countries across the globe with a higher fatality rate among the ...

    Authors: Alok Ranjan and V. R. Muraleedharan

    Citation: Globalization and Health 2020 16:93

    Content type: Research

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  26. According to the World Health Organization (WHO), the outbreak of coronavirus disease in 2019 (COVID-19) has been declared as a pandemic and public health emergency that infected more than 5 million people wor...

    Authors: Degena Bahrey Tadesse, Shishay Wahdey, Melaku Negash, Ebud Ayele, Teklehaimanot Gereziher Haile, Kbrom Gemechu Kiros, Yohannes Ashebir Tesfamichael and Kiros Belay Gebrekidan

    Citation: Asthma Research and Practice 2020 6:11

    Content type: Research

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  27. Determining the infectiousness of patients with coronavirus disease 2019 is crucial for patient management. Medical staff usually refer to the results of reverse transcription polymerase chain reaction tests i...

    Authors: Masafumi Kanamoto, Masaru Tobe, Tomonori Takazawa and Shigeru Saito

    Citation: Journal of Medical Case Reports 2020 14:191

    Content type: Case report

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  28. As the global pandemic of corona virus (COVID-19) spreads across continents and communities, people are forced to respond with strict preventive measures such as staying at home and keeping social distance. In...

    Authors: Gebremeskel Tukue Gebrewahd, Gebreamlak Gebremedhn Gebremeskel and Degena Bahrey Tadesse

    Citation: Reproductive Health 2020 17:152

    Content type: Research

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  29. Peripartum deaths remain significantly high in low- and middle-income countries, including Kenya. The COVID-19 pandemic has disrupted essential services, which could lead to an increase in maternal and neonata...

    Authors: Rachel Wangari Kimani, Rose Maina, Constance Shumba and Sheila Shaibu

    Citation: Human Resources for Health 2020 18:75

    Content type: Review

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  30. A novel coronavirus named severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China, in December 2019. The virus, known as COVID-19, is recognized as a potentially life-threatening di...

    Authors: Tayebeh Rashidian, Nasibeh Sharifi, Azita Fathnezhad-Kazemi, Fatemeh Mirzamrajani, Sajad Nourollahi and Abas Ghaysouri

    Citation: Journal of Medical Case Reports 2020 14:186

    Content type: Case report

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  31. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is the most Serious Cutaneous Adverse Reaction (SCAR) often with a fatal outcome. Coronavirus Disease (COVID-19) is caused by Severe Acute Respirat...

    Authors: Carlo Maria Rossi, Flavio Niccolò Beretta, Grazia Traverso, Sandro Mancarella and Davide Zenoni

    Citation: Clinical and Molecular Allergy 2020 18:19

    Content type: Case Report

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  32. COVID-19 epidemic has paralleled with the so called infodemic, where countless pieces of information have been disseminated on putative risk factors for COVID-19. Among those, emerged the notion that people su...

    Authors: Rossella Murtas, Anita Andreano, Federico Gervasi, Davide Guido, David Consolazio, Sara Tunesi, Laura Andreoni, Maria Teresa Greco, Maria Elena Gattoni, Monica Sandrini, Antonio Riussi and Antonio Giampiero Russo

    Citation: Autoimmunity Highlights 2020 11:15

    Content type: Original Research

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  33. We aimed to test our hypothesis that additional administration of traditional Japanese (Kampo) medicine, kakkonto (kakkon-to: KT) and shosaikotokakikyosekko (sho-saiko-to-ka-kikyo-sekko: SSKKS), is more effect...

    Authors: Shin Takayama, Takao Namiki, Takashi Ito, Ryutaro Arita, Hajime Nakae, Seiichi Kobayashi, Tetsuhiro Yoshino, Tomoaki Ishigami, Koichiro Tanaka, Mosaburo Kainuma, Kotaro Nochioka, Airi Takagi, Masaru Mimura, Takuhiro Yamaguchi and Tadashi Ishii

    Citation: Trials 2020 21:827

    Content type: Letter

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  34. With the threat of coronavirus disease 2019 (Covid-19) enduring in the United States, effectively and equitably implementing testing, tracing, and self-isolation as key prevention and detection strategies rema...

    Authors: Tyler A. Jacobson, Lauren E. Smith, Lisa R. Hirschhorn and Mark D. Huffman

    Citation: International Journal for Equity in Health 2020 19:170

    Content type: Commentary

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  35. Cardiometabolic disorders may worsen Covid-19 outcomes. We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic multimorbidity.

    Authors: Ernesto Maddaloni, Luca D’Onofrio, Francesco Alessandri, Carmen Mignogna, Gaetano Leto, Giuseppe Pascarella, Ivano Mezzaroma, Miriam Lichtner, Paolo Pozzilli, Felice Eugenio Agrò, Monica Rocco, Francesco Pugliese, Andrea Lenzi, Rury R. Holman, Claudio Maria Mastroianni and Raffaella Buzzetti

    Citation: Cardiovascular Diabetology 2020 19:164

    Content type: Original investigation

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  36. The pandemic COVID-19 abruptly exploded, taking most health professionals around the world unprepared. Italy, the first European country to be hit violently, was forced to activate the lockdown in mid-February...

    Authors: Vincenzo Patella, Gabriele Delfino, Giovanni Florio, Giuseppe Spadaro, Fulvia Chieco Bianchi, Gianerico Senna and Mario Di Gioacchino

    Citation: Clinical and Molecular Allergy 2020 18:18

    Content type: Review

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  37. In all epidemics, healthcare staff are at the centre of risks and damages caused by pathogens. Today, nurses and physicians are faced with unprecedented work pressures in the face of the COVID-19 pandemic, res...

    Authors: Nader Salari, Habibolah Khazaie, Amin Hosseinian-Far, Hooman Ghasemi, Masoud Mohammadi, Shamarina Shohaimi, Alireza Daneshkhah, Behnam Khaledi-Paveh and Melika Hosseinian-Far

    Citation: Globalization and Health 2020 16:92

    Content type: Research

    Published on:

  38. The COVID-19 pandemic and social distancing rules necessitated the suspension of all in-person learning activities at our institution. Consequently, distance learning became essential. We adapted a high-fideli...

    Authors: Shivani M. Patel, Christina R. Miller, Adam Schiavi, Serkan Toy and Deborah A. Schwengel

    Citation: Advances in Simulation 2020 5:26

    Content type: Innovation

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  39. The objective of this review was to examine the current guidelines for infection prevention and control (IPAC) of coronavirus disease-19 (COVID-19) or other coronaviruses in adults 60 years or older living in ...

    Authors: Patricia Rios, Amruta Radhakrishnan, Chantal Williams, Naveeta Ramkissoon, Ba’ Pham, Gordon V. Cormack, Maura R. Grossman, Matthew P. Muller, Sharon E. Straus and Andrea C. Tricco

    Citation: Systematic Reviews 2020 9:218

    Content type: Research

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  40. A recent editorial urged those working in global mental health to “change the conversation” on coronavirus disease (Covid-19) by putting more focus on the needs of people with severe mental health conditions. ...

    Authors: Richard Mpango, Jasmine Kalha, Donat Shamba, Mary Ramesh, Fileuka Ngakongwa, Arti Kulkarni, Palak Korde, Juliet Nakku and Grace K. Ryan

    Citation: Globalization and Health 2020 16:90

    Content type: Commentary

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  41. Health care workers exposed to COVID-19 might be at increased risk of developing mental health problems. The study aimed to identify factors associated with anxiety, depression and insomnia among health worker...

    Authors: Pratik Khanal, Navin Devkota, Minakshi Dahal, Kiran Paudel and Devavrat Joshi

    Citation: Globalization and Health 2020 16:89

    Content type: Research

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  42. Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favou...

    Authors: Francesca Caccuri, Alberto Zani, Serena Messali, Marta Giovanetti, Antonella Bugatti, Giovanni Campisi, Federica Filippini, Erika Scaltriti, Massimo Ciccozzi, Simona Fiorentini and Arnaldo Caruso

    Citation: Journal of Translational Medicine 2020 18:362

    Content type: Research

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  43. COVID-19 has resulted in an increased demand for eHealth services globally. There is emerging evidence for the efficacy for group eHealth interventions that support population-based mental health and wellbeing...

    Authors: Cheryl L. Currie, Richard Larouche, M. Lauren Voss, Erin K. Higa, Rae Spiwak, David Scott and Treena Tallow

    Citation: Systematic Reviews 2020 9:217

    Content type: Protocol

    Published on:

  44. Restricting mobility is a central aim for lowering contact rates and preventing COVID-19 transmission. Yet the impact on mobility of different non-pharmaceutical countermeasures in the earlier stages of the pa...

    Authors: Matia Vannoni, Martin McKee, Jan C. Semenza, Chris Bonell and David Stuckler

    Citation: Globalization and Health 2020 16:85

    Content type: Research

    Published on: