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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. The coronavirus-19 (COVID-19) has reached pandemic status and is affecting countries all over the world. The COVID-19 pandemic is accompanied by various stressors that require adjustment in everyday life and p...

    Authors: Noemi Anja Brog, Julia Katharina Hegy, Thomas Berger and Hansjörg Znoj
    Citation: Trials 2021 22:171
    Content type: Study protocol Published on:

  2. Pregnancy seems to increase the risk of thrombotic thrombocytopenic purpura (TTP) relapses and make the TTP more severe in any of the pregnancy trimesters, or even during the postpartum period.

    Authors: Soheila Aminimoghaddam, Narjes Afrooz, Setare Nasiri, Ozra Motaghi Nejad and Fatemeh Mahmoudzadeh
    Citation: Journal of Medical Case Reports 2021 15:104
    Content type: Case report Published on:

  3. The impact of COVID-19 pandemic on mental health of pregnant and lactating women is unclear. This study aimed to assess the impact of COVID-19 on psychological health, sexual function, and quality of life (QoL...

    Authors: Negin Mirzaei, Shahideh Jahanian Sadatmahalleh, Mahnaz Bahri Khomami, Ashraf Moini and Anoshirvan Kazemnejad
    Citation: Health and Quality of Life Outcomes 2021 19:66
    Content type: Research Published on:

  4. As of mid-June 2020, 7,500,000 people were infected with SARS-CoV-2 worldwide and 420,000 people died, mainly from coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS). COVID-...

    Authors: Aurélien Mazeraud, Bruno Gonçalves, Philippe Aegerter, Letizia Mancusi, Christine Rieu, Fernando Bozza, Khaoussou Sylla, Shidasp Siami and Tarek Sharshar
    Citation: Trials 2021 22:170
    Content type: Study protocol Published on:

  5. Disease outbreak not only carries the risk of death to the public due to the infection, but it also can lead to unbearable psychological impact on the mental health of the individuals. This study aims to explo...

    Authors: Reza Shahriarirad, Amirhossein Erfani, Keivan Ranjbar, Amir Bazrafshan and Alireza Mirahmadizadeh
    Citation: International Journal of Mental Health Systems 2021 15:19
    Content type: Research Published on:

  6. We report a high-risk case of a coronavirus disease 19 (COVID-19)-positive patient with comorbidities including diabetes mellitus (DM), hypertension (HTN), hypothyroidism and chronic kidney disease (CKD), trea...

    Authors: Alka Mishra, Sumitra A. Bentur, Sonika Thakral, Rahul Garg and Bhanu Duggal
    Citation: Journal of Medical Case Reports 2021 15:95
    Content type: Case report Published on:

  7. In Belgium, confinement measures were introduced on the 13th of March 2020 to curb the spread of the coronavirus disease (COVID-19). These measures may affect health behaviours of the population such as eating...

    Authors: Sabine Drieskens, Nicolas Berger, Stefanie Vandevijvere, Lydia Gisle, Elise Braekman, Rana Charafeddine, Karin De Ridder and Stefaan Demarest
    Citation: Archives of Public Health 2021 79:22
    Content type: Research Published on:

  8. The novel coronavirus disease (Covid-19) has spread quickly worldwide with dramatic consequences on our daily lives. Adverse psychosocial consequences of Covid-19 might be particularly severe for children and ...

    Authors: Josefine Rothe, Judith Buse, Anne Uhlmann, Annet Bluschke and Veit Roessner
    Citation: Child and Adolescent Psychiatry and Mental Health 2021 15:11
    Content type: Research article Published on:

  9. Very little is known about the risk that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection poses to cancer patients, many of whom are immune compromised causing them to be more susce...

    Authors: D. Madduri, S. Parekh, T. B. Campbell, F. Neumann, F. Petrocca and S. Jagannath
    Citation: Journal of Medical Case Reports 2021 15:90
    Content type: Case report Published on:

  10. The sharing of individual participant-level data from COVID-19 trials would allow re-use and secondary analysis that can help accelerate the identification of effective treatments. The sharing of trial data is...

    Authors: Rebecca Li, Megan von Isenburg, Marcia Levenstein, Stan Neumann, Julie Wood and Ida Sim
    Citation: Trials 2021 22:153
    Content type: Research Published on:

  11. Coronavirus disease 2019 (COVID-19), the global pandemic that has spread throughout the world, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the limited scientific evidence o...

    Authors: Maryam Rabiei, Tahereh Soori, Amene Abiri, Zohreh Farsi, Arshia Shizarpour and Reihaneh Pirjani
    Citation: Journal of Medical Case Reports 2021 15:87
    Content type: Case report Published on:

  12. China and the rest of the world are experiencing an outbreak of the 2019 novel coronavirus disease (COVID-19). Patients with cancer are more susceptible to viral infection and are more likely to develop severe...

    Authors: Zhilan Chen, Chun Zhang, Jiu Yin, Xin Xin, Hemei Li, Yapei Wang, Benjamin K. Tsang and Qinghua Zhang
    Citation: Journal of Ovarian Research 2021 14:35
    Content type: Review Published on:

  13. To control the spread of the new SARS-CoV-2 infection's disease (COVID-19), appropriate precautionary behaviors by the public should be promoted. There are international differences in public cognitive and beh...

    Authors: Akihiro Shiina, Tomihisa Niitsu, Osamu Kobori, Keita Idemoto, Tasuku Hashimoto, Tsuyoshi Sasaki, Yoshito Igarashi, Eiji Shimizu, Michiko Nakazato, Kenji Hashimoto and Masaomi Iyo
    Citation: Annals of General Psychiatry 2021 20:13
    Content type: Primary research Published on:

  14. The COVID-19 crisis has had profound impacts on health service provision, particularly those providing client facing services. Supervised injecting facilities and drug consumption rooms across the world have b...

    Authors: Amanda Roxburgh, Marianne Jauncey, Carolyn Day, Mark Bartlett, Shelley Cogger, Paul Dietze, Suzanne Nielsen, Julie Latimer and Nico Clark
    Citation: Harm Reduction Journal 2021 18:20
    Content type: Opinion Published on:

  15. COVID-19 has spread rapidly around the world, affecting a large percentage of the population. When lifting certain mandatory measures for an economic restart, robust surveillance must be established and implem...

    Authors: Yangyang Sun, Lei Yu, Chengxi Liu, Shanting Ye, Wei Chen, Dechang Li and Weiren Huang
    Citation: Journal of Translational Medicine 2021 19:74
    Content type: Research Published on:

  16. Grocery food taxes represent a stable tax revenue stream for state and municipal government during times of adverse economic shocks such as that observed under the coronavirus disease 2019 (COVID-19) pandemic....

    Authors: Lingxiao Wang, Yuqing Zheng, Steven Buck, Diansheng Dong and Harry M. Kaiser
    Citation: Health Economics Review 2021 11:5
    Content type: Research Published on:

  17. Eating disorders (EDs) are among the most difficult psychiatric disorders to treat in normal conditions. They are likely even more difficult to manage in at-risk conditions such as the COVID-19 pandemic. Curre...

    Authors: Serur Yaffa, Enoch-Levy Adi, Pessach Itai, Joffe-Milstein Marit, Gothelf Doron and Stein Daniel
    Citation: Journal of Eating Disorders 2021 9:17
    Content type: Case report Published on:

  18. The rapid emergence and the high disease burden of the novel coronavirus SARS-CoV-2 have created a medical need for readily available drugs that can decrease viral replication or blunt the hyperinflammatory st...

    Authors: Iwein Gyselinck, Laurens Liesenborghs, Ewout Landeloos, Ann Belmans, Geert Verbeke, Peter Verhamme, Robin Vos and W. Janssens
    Citation: Trials 2021 22:126
    Content type: Study protocol Published on:

    The Correction to this article has been published in Trials 2021 22:187

  19. The COVID-19 pandemic has rapidly changed the landscape of medical care and the healthcare system needs to quickly adapt in order to continue providing optimal medical care to hospitalized patients in an effic...

    Authors: Marcio L. Griebeler, Kevin M. Pantalone, Ron Gambino, David Shewmon, Jay Morrow, Daniel Mendlovic, Vinni Makin, Marwan Hamaty, Sana Hasan, M. Cecilia Lansang, Keren Zhou and Bartolome Burguera
    Citation: Clinical Diabetes and Endocrinology 2021 7:5
    Content type: Commentary Published on:

  20. The coronavirus disease 2019 (COVID-19) pandemic has caused irreparable damage to society, and the damage continues. Pediatricians are confronted with COVID-19 in a variety of presentations, which may lead to...

    Authors: Marjan Tariverdi, Nazanin Farahbakhsh, Hamed Gouklani, Fatemeh Khosravifar and Mohammad Tamaddondar
    Citation: Journal of Medical Case Reports 2021 15:65
    Content type: Case report Published on:

  21. To investigate the potential beneficial effect of fecal microbiota transplantation (FMT) on gastrointestinal symptoms, gut dysbiosis and immune status in discharged COVID-19 patients.

    Authors: Fengqiong Liu, Shanliang Ye, Xin Zhu, Xuesong He, Shengzhou Wang, Yinbao Li, Jiang Lin, Jingsu Wang, Yonggan Lin, Xin Ren, Yong Li and Zhaoqun Deng
    Citation: Journal of Medical Case Reports 2021 15:60
    Content type: Case report Published on:

  22. The aim of RApid community Point-of-care Testing fOR COVID-19 (RAPTOR-C19) is to assess the diagnostic accuracy of multiple current and emerging point-of-care tests (POCTs) for active and past SARS-CoV2 infect...

    Authors: Brian D. Nicholson, Gail Hayward, Philip J. Turner, Joseph J. Lee, Alexandra Deeks, Mary Logan, Abigail Moore, Anna Seeley, Thomas Fanshawe, Jason Oke, Constantinos Koshiaris, James P. Sheppard, Uy Hoang, Vaishnavi Parimalanathan, George Edwards, Harshana Liyange…
    Citation: Diagnostic and Prognostic Research 2021 5:4
    Content type: Protocol Published on:

  23. Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 strain, was first identified in late 2019 in China. The outcomes of patients affected by the virus can worsen, deve...

    Authors: Marcela Larissa Costa, Carlos Adriano Santos Souza, Ana Caroline Cardoso Silva, Dayane Franciely Conceição Santos, Edilene Fernandes Nonato, Francismayne Batista Santana, Giselle dos Santos Dias, Jessyca Teles Barreto, Laís Santos Costa, Maria Carolina Barros Costa, Tamila das Neves Ferreira, Jeniffer Santos Santana, Raquel Simões Mendes-Netto, Tereza Virgínia Silva Bezerra do Nascimento, Marco Antônio Prado Nunes and Márcia Ferreira Cândido de Souza
    Citation: Systematic Reviews 2021 10:51
    Content type: Protocol Published on:

  24. This article describes how one trial site of the Refugee Emergency: Defining and Implementing Novel Evidence-based psychosocial interventions (RE-DEFINE) study, designed to evaluate a Self Help+ intervention w...

    Authors: Lauren Walker, Della Bailey, Rachel Churchill and Emily Peckham
    Citation: Trials 2021 22:117
    Content type: Letter Published on:

  25. Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious dise...

    Authors: Luciana C. Ribeiro, Bruno Deltreggia Benites, Raisa G. Ulaf, Thyago A. Nunes, Carolina Costa-Lima, Marcelo Addas-Carvalho, José Luiz Proenca-Modena, Fabiana Granja, Vitor Antonio da Costa, Adriana da Silva Santos Duarte, Audrey Basso Zangirolami, Emerson Clayton Amaro, Eli Mansour, Ricardo L. Zollner and Licio A. Velloso
    Citation: Allergy, Asthma & Clinical Immunology 2021 17:14
    Content type: Case Report Published on:

  26. Maldives reported its first Coronavirus disease 2019 (COVID-19) case on March 7th, 2020. Since then more than 9400 positive cases and 33 deaths have been reported. Recently studies have shown that COVID-19 pat...

    Authors: Rajib Kumar Dey, Abdullah Isneen Hilmy, Hisham Ahmed Imad, Abdul Azeez Yoosuf and Ali Abdulla Latheef
    Citation: Journal of Medical Case Reports 2021 15:57
    Content type: Case report Published on:

  27. To examine, through photo-elicitation, the personal and professional impact of the COVID-19 pandemic on mental health professionals working with children and adolescents around the globe.

    Authors: Olivia D. Herrington, Ashley Clayton, Laelia Benoit, Cecil Prins-Aardema, Madeline DiGiovanni, Indigo Weller and Andrés Martin
    Citation: Child and Adolescent Psychiatry and Mental Health 2021 15:5
    Content type: Research article Published on:

    The Correction to this article has been published in Child and Adolescent Psychiatry and Mental Health 2021 15:14

  28. Coronavirus disease 2019 (COVID-19) is an infection with possible serious consequences. The plasma of recovered patients might serve as treatment, which we aim to assess in the form of a prospective meta-analy...

    Authors: Lajos Szakó, Nelli Farkas, Szabolcs Kiss, Szilárd Váncsa, Noémi Zádori, Nóra Vörhendi, Bálint Erőss, Péter Hegyi and Hussain Alizadeh
    Citation: Trials 2021 22:112
    Content type: Methodology Published on:

  29. Pneumonitis belongs to the fatal toxicities of anti-PD-1/PD-L1 treatments. Its diagnosis is based on immunotherapeutic histories, clinical symptoms, and the computed tomography (CT) imaging. The radiological f...

    Authors: Ying Dai, Sha Liu, Yiruo Zhang, Xiaoqiu Li, Zhiyan Zhao, Pingping Liu and Yingying Du
    Citation: Journal of Medical Case Reports 2021 15:41
    Content type: Case report Published on:

  30. Through their support of local agriculture, relationships, and healthy diets, farmers markets can contribute to a sustainable food system. Markets like the Yellowknife Farmers Market (YKFM) are social spaces t...

    Authors: Josalyn Radcliffe, Kelly Skinner, Andrew Spring, Lise Picard, France Benoit and Warren Dodd
    Citation: Nutrition Journal 2021 20:12
    Content type: Research Published on:

  31. The Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial is a global adaptive platform trial of hospitalized patients with COVID-19. We describe implementation at the first US ...

    Authors:
    Citation: Trials 2021 22:100
    Content type: Methodology Published on:

    The Correction to this article has been published in Trials 2021 22:145

  32. SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible f...

    Authors: Ali Saeedi-Boroujeni and Mohammad-Reza Mahmoudian-Sani
    Citation: Journal of Inflammation 2021 18:3
    Content type: Hypothesis Published on:

  33. Previous reports have shown various cardiac complications to be associated with COVID-19 including: myocardial infarction, microembolic complications, myocardial injury, arrythmia, heart failure, coronary vaso...

    Authors: Lauren Cairns, Yazeed Abed El Khaleq, Will Storrar and Michaela Scheuermann-Freestone
    Citation: Journal of Medical Case Reports 2021 15:31
    Content type: Case report Published on:

  34. Systemic lupus erythematosus (SLE) is a complex and challenging autoimmune disease. Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a novel viral agent that can cause a life-threatening respira...

    Authors: Batool Zamani, Seyed-Masoud Moeini Taba and Mohammad Shayestehpour
    Citation: Journal of Medical Case Reports 2021 15:29
    Content type: Case report Published on:

  35. The COVID-19 pandemic has made unprecedented impact on the psychological health of university students, a population vulnerable to distress and mental health disorders. This study investigated psychiatric symp...

    Authors: Shufang Sun, Simon B. Goldberg, Danhua Lin, Shan Qiao and Don Operario
    Citation: Globalization and Health 2021 17:15
    Content type: Research Published on:

    The Correction to this article has been published in Globalization and Health 2021 17:52

  36. Lung function impairment persists in 55% of critical COVID-19 patients three months after ICU discharge. Patient lung function, exercise capacity, radiologic, and quality of life data suggest impairment is rel...

    Authors: Laurent Truffaut, Lucas Demey, Anne Violette Bruyneel, Alain Roman, Stephane Alard, Nathalie De Vos and Marie Bruyneel
    Citation: Respiratory Research 2021 22:29
    Content type: Letter to the Editor Published on:

  37. With the ongoing COVID-19 outbreak, healthcare systems across the world have been pushed to the brink. The approach of traditional healthcare systems to disaster preparedness and prevention has demonstrated in...

    Authors: Shuangyi Sun, Zhen Xie, Keting Yu, Bingqian Jiang, Siwei Zheng and Xiaoting Pan
    Citation: Globalization and Health 2021 17:14
    Content type: Review Published on:

  38. SARS-CoV-2, the virus that causes COVID-19, enters the cells through a mechanism dependent on its binding to angiotensin-converting enzyme 2 (ACE2), a protein highly expressed in the lungs. The putative viral-...

    Authors: Eli Mansour, Flávia F. Bueno, José C. de Lima-Júnior, Andre Palma, Milena Monfort-Pires, Bruna Bombassaro, Eliana P. Araujo, Ana Flavia Bernardes, Raisa G. Ulaf, Thyago A. Nunes, Luciana C. Ribeiro, Antônio Luís E. Falcão, Thiago Martins Santos, Plinio Trabasso, Rachel P. Dertkigil, Sergio S. Dertkigil…
    Citation: Trials 2021 22:71
    Content type: Study protocol Published on:

  39. COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. At the time this clinical trial was planned, there were no available vaccine or ther...

    Authors: Elena Diago-Sempere, José Luis Bueno, Aránzazu Sancho-López, Elena Múñez Rubio, Ferrán Torres, Rosa Malo de Molina, Ana Fernández-Cruz, Isabel Salcedo de Diego, Ana Velasco-Iglesias, Concepción Payares-Herrera, Inmaculada Casas Flecha, Cristina Avendaño-Solà, Rafael Duarte Palomino, Antonio Ramos-Martínez and Belén Ruiz-Antorán
    Citation: Trials 2021 22:70
    Content type: Study protocol Published on:

  40. Lockdowns can be an effective pandemic response strategy that can buy much needed time to slow disease transmission and adequately scale up preventative, diagnostic, and treatment capacities. However, the broa...

    Authors: Oghenowede Eyawo, A. M. Viens and Uchechukwu Chidiebere Ugoji
    Citation: Globalization and Health 2021 17:13
    Content type: Commentary Published on:

  41. Vertical transmission of covid-19 is possible; its risk factors are worth researching. The placental changes found in pregnant women have a definite impact on the foetus.

    Authors: Etienne Kajibwami Birindwa, Guy Mulinganya Mulumeoderhwa, Olivier Nyakio, Guy-Quesney Mateso Mbale, Serge Zigabe Mushamuka, Jeanne Maningo Materanya, Pierrot Mulumeoderhwa Kahasha, Yvette Kujirakwinja Bisimwa, Freddy Mirindi Kampara, Jules Mongane Irenge, Isaac Barhishindi Kibalama, Pierre Kabuya Luzadi, Espoir Bwenge Malembaka, Daniel Garhalangwa-Na-Muntu Mayeri, Marius Baguma and Ghislain Bisimwa Balaluka
    Citation: Maternal Health, Neonatology and Perinatology 2021 7:6
    Content type: Case report Published on:

  42. The pandemic caused by Sars-CoV-2 (COVID-19) has been a great concern for public and mental health systems worldwide. The identification of risk groups is essential for the establishment of preventive and ther...

    Authors: Ellen Mello Borgonhi, Vanessa Loss Volpatto, Felipe Ornell, Francisco Diego Rabelo-da-Ponte and Felix Henrique Paim Kessler
    Citation: Addiction Science & Clinical Practice 2021 16:5
    Content type: Commentary Published on:

  43. The World Health Organization declared the outbreak of COVID-19 as a global pandemic on the 11th March 2020. As a result, the UK Government imposed severe restrictions on working and social contact as part of ...

    Authors: Hannah Shaw, Sarah Robertson and Nadia Ranceva
    Citation: Journal of Eating Disorders 2021 9:14
    Content type: Research article Published on:

  44. There is a dearth of literature on best practices for managing clinical trials, and little is understood on the role of the clinical trial manager. The COVID-19 pandemic has brought this into focus, and the co...

    Authors: Frances Shiely, Jean Foley, Amy Stone, Emma Cobbe, Shaunagh Browne, Ellen Murphy, Maeve Kelsey, Joanne Walsh-Crowley and Joseph A. Eustace
    Citation: Trials 2021 22:62
    Content type: Commentary Published on:

  45. COVID-19 causes acute respiratory distress syndrome (ARDS) and depletes the lungs of surfactant, leading to prolonged mechanical ventilation and death. The feasibility and safety of surfactant delivery in COVI...

    Authors: Simone Piva, Robert M. DiBlasi, April E. Slee, Alan H. Jobe, Aldo M. Roccaro, Matteo Filippini, Nicola Latronico, Michele Bertoni, John C. Marshall and Michael A. Portman
    Citation: Respiratory Research 2021 22:20
    Content type: Research Published on:

  46. The Covid-19 pandemic affects maternal health both directly and indirectly, and direct and indirect effects are intertwined. To provide a comprehensive overview on this broad topic in a rapid format behooving ...

    Authors: Bethany Kotlar, Emily Michelle Gerson, Sophia Petrillo, Ana Langer and Henning Tiemeier
    Citation: Reproductive Health 2021 18:10
    Content type: Review Published on:

    The Correction to this article has been published in Reproductive Health 2023 20:52

  47. There is a lot of debate about the effects of smoking on COVID-19. A recent fixed-effects meta-analysis found smoking to be associated with disease severity among hospitalized patients, but other studies repor...

    Authors: Konstantinos Farsalinos, Pantelis G. Bagos, Theodoros Giannouchos, Raymond Niaura, Anastasia Barbouni and Konstantinos Poulas
    Citation: Harm Reduction Journal 2021 18:9
    Content type: Research Published on:

  49. Some studies investigated epidemiological and clinical features of laboratory-confirmed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the virus causing coronavirus disease 2019 (CO...

    Authors: Giovanna E. Carpagnano, Giovanni Migliore, Salvatore Grasso, Vito Procacci, Emanuela Resta, Francesco Panza and Onofrio Resta
    Citation: Respiratory Research 2021 22:16
    Content type: Research Published on:

  50. Hyperreflective lesions at the level of ganglion cell (GCL) and inner plexiform retinal layers (IPL) by optical coherence tomography (OCT) and cotton wool spots in the examination of the eye fundus have recent...

    Authors: José M. Ortiz-Egea, Jorge Ruiz-Medrano and José M. Ruiz-Moreno
    Citation: Journal of Medical Case Reports 2021 15:15
    Content type: Case report Published on: