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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. The COVID-19 pandemic has led to more than 760,000 deaths worldwide (correct as of 16th August 2020). Studies suggest a hyperinflammatory response is a major cause of disease severity and death. Identitfying C...

    Authors: H. Burke, A. Freeman, D. C. Cellura, B. L. Stuart, N. J. Brendish, S. Poole, F. Borca, H. T. T. Phan, N. Sheard, S. Williams, C. M. Spalluto, K. J. Staples, T. W. Clark and T. M. A. Wilkinson

    Citation: Respiratory Research 2020 21:245

    Content type: Research

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  2. COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that can affect lung physiology encompassing a wide spectrum of severities, ranging from asymptomatic and mild symptoms to severe and fatal case...

    Authors: Carla J. Goldin, Ramiro Vázquez, Fernando P. Polack and Damian Alvarez-Paggi

    Citation: Translational Medicine Communications 2020 5:15

    Content type: Review

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  3. More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in o...

    Authors: Maurice A. Canham, John D. M. Campbell and Joanne C. Mountford

    Citation: Journal of Translational Medicine 2020 18:359

    Content type: Review

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  4. COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million ...

    Authors: Sina Salajegheh Tazerji, Phelipe Magalhães Duarte, Parastoo Rahimi, Fatemeh Shahabinejad, Santosh Dhakal, Yashpal Singh Malik, Awad A. Shehata, Juan Lama, Jörn Klein, Muhammad Safdar, Md. Tanvir Rahman, Krzysztof J. Filipiak, Alfonso J. Rodríguez-Morales, Md. Abdus Sobur, Farrokhreza Kabir, Bita Vazir…

    Citation: Journal of Translational Medicine 2020 18:358

    Content type: Review

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  5. Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unres...

    Authors: Houwei Du, Xiaobin Pan, Nan Liu, Junnian Chen, Xiaoling Chen, David J. Werring, Gareth Ambler, Xiaoqing Li, Ronghua Chen, Yixian Zhang, Huayao Huang, Feifei Lin, Pincang Xia, Chao Chen, Zhenyang Zheng, Sangru Wu…

    Citation: Respiratory Research 2020 21:241

    Content type: Research

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  6. Nepal, a South Asian country, was in nationwide lockdown for nearly three months in 2020 with partial restrictions still in place. Much worryingly, COVID-19 induced restrictions have confined women and young g...

    Authors: Minakshi Dahal, Pratik Khanal, Sajana Maharjan, Bindu Panthi and Sushil Nepal

    Citation: Globalization and Health 2020 16:84

    Content type: Commentary

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  7. Mali, like the rest of the world, has seen a rapid spread of COVID-19 since the first report of imported cases. Despite being a low-income country, Mali has leveraged scientific research resources via coordina...

    Authors: Seydou Doumbia, Ydrissa Sow, Mahamadou Diakite and Chuen-Yen Lau

    Citation: Health Research Policy and Systems 2020 18:105

    Content type: Commentary

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  8. Spontaneous pneumothorax is an uncommon complication of COVID-19 viral pneumonia. The exact incidence and risk factors are still unknown. Herein we review the incidence and outcomes of pneumothorax in over 300...

    Authors: Massa Zantah, Eduardo Dominguez Castillo, Ryan Townsend, Fusun Dikengil and Gerard J. Criner

    Citation: Respiratory Research 2020 21:236

    Content type: Research

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  9. Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associate...

    Authors: Donogh Maguire, Marylynne Woods, Conor Richards, Ross Dolan, Jesse Wilson Veitch, Wei M. J. Sim, Olivia E. H. Kemmett, David C. Milton, Sophie L. W. Randall, Ly D. Bui, Nicola Goldmann, Allan Cameron, Barry Laird, Dinesh Talwar, Ian Godber, Alan Davidson…

    Citation: Journal of Translational Medicine 2020 18:354

    Content type: Research

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  10. The outbreak of Coronavirus disease of 2019 (COVID-19) caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has posed a serious health threat. The increasing number of COVID-19 cases aro...

    Authors: Manoj Kumar and Souhaila Al Khodor

    Citation: Journal of Translational Medicine 2020 18:353

    Content type: Review

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  11. Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help both at the clinical level to identify individuals at higher risk from the disease and a...

    Authors: Simona Pisanti, Joris Deelen, Anna Maria Gallina, Mariella Caputo, Marianna Citro, Mario Abate, Nicoletta Sacchi, Carmine Vecchione and Rosanna Martinelli

    Citation: Journal of Translational Medicine 2020 18:352

    Content type: Research

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  12. The COVID-19 pandemic is disrupting normal life globally, every area of life is touched. The pandemic demands quick action and as new information emerges, reliable synthesises and guidelines for care are urgen...

    Authors: Welma Lubbe, Elina Botha, Hannakaisa Niela-Vilen and Penny Reimers

    Citation: International Breastfeeding Journal 2020 15:82

    Content type: Review

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  13. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19) pandemic, has infected millions of people and caused hundreds of thousands of deaths. While COV...

    Authors: Jeon-Young Kang, Alexander Michels, Fangzheng Lyu, Shaohua Wang, Nelson Agbodo, Vincent L. Freeman and Shaowen Wang

    Citation: International Journal of Health Geographics 2020 19:36

    Content type: Research

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  14. The number of cases of novel coronavirus disease 2019 (COVID-19) in Japan have risen since the first case was reported on January 24, 2020, and 6225 infections have been reported as of June 30, 2020. On April ...

    Authors: Yuya Nogami, Yusuke Kobayashi, Kosuke Tsuji, Megumi Yokota, Hiroshi Nishio, Masaru Nakamura, Wataru Yamagami, Tohru Morisada, Eiichiro Tominaga, Kouji Banno and Daisuke Aoki

    Citation: Journal of Ovarian Research 2020 13:105

    Content type: Case report

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  15. In this case report, we describe the trajectory of recovery of a young, healthy patient diagnosed with coronavirus disease 2019 who developed acute respiratory distress syndrome. The purpose of this case repor...

    Authors: Kirby P. Mayer, Jamie L. Sturgill, Anna G. Kalema, Melissa K. Soper, Sherif M. Seif, Evan P. Cassity, Jimmi Hatton Kolpek, Esther E. Dupont-Versteegden, Ashley A. Montgomery-Yates and Peter E. Morris

    Citation: Journal of Medical Case Reports 2020 14:161

    Content type: Case report

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  16. Refugees and internally displaced persons in humanitarian settings are particularly susceptible to the spread of infectious illnesses such as COVID-19 due to overcrowding and inadequate access to clean water, ...

    Authors: Jude Alawa, Nawara Alawa, Adam Coutts, Richard Sullivan, Kaveh Khoshnood and Fouad M. Fouad

    Citation: Conflict and Health 2020 14:64

    Content type: Commentary

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  17. The main aim of the study is to evaluate the efficacy of a single dose of sarilumab, in subcutaneous administration, in hospitalised patients with moderate to early severe COVID-19 infection compared to the cu...

    Authors: Rosario Garcia-Vicuña, Francisco Abad-Santos, Isidoro González-Alvaro, Francisco Ramos-Lima and Jesús Sanz Sanz

    Citation: Trials 2020 21:772

    Content type: Letter

    Published on:

  18. The OVID study will demonstrate whether prophylactic-dose enoxaparin improves survival and reduces hospitalizations in symptomatic ambulatory patients aged 50 or older diagnosed with COVID-19, a novel viral di...

    Authors: Stefano Barco, Roland Bingisser, Giuseppe Colucci, André Frenk, Bernhard Gerber, Ulrike Held, Francois Mach, Lucia Mazzolai, Marc Righini, Thomas Rosemann, Tim Sebastian, Rebecca Spescha, Stefan Stortecky, Stephan Windecker and Nils Kucher

    Citation: Trials 2020 21:770

    Content type: Letter

    Published on:

  19. This case report demonstrates pericardial effusion, acute pericarditis, and cardiac tamponade in an otherwise healthy woman who had a positive test result for coronavirus disease 2019. Few case reports have be...

    Authors: Christina Walker, Vincent Peyko, Charles Farrell, Jeanine Awad-Spirtos, Matthew Adamo and John Scrocco

    Citation: Journal of Medical Case Reports 2020 14:158

    Content type: Case report

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  20. The Arab ethnic minority makes up 21% of Israel’s population, yet comprised just 8.8% of confirmed cases and 3.6% of deaths from COVID-19, despite their higher risk profile and greater burden of underlying ill...

    Authors: Mor Saban, Vicki Myers and Rachel Wilf-Miron

    Citation: International Journal for Equity in Health 2020 19:154

    Content type: Research

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  21. The first wave of the Covid-19 pandemic hit Israel in late February 2020. The present study examines patterns of the first wave of Covid-19 morbidity in Israel at the macro level, during the period of late Feb...

    Authors: Daphna Birenbaum-Carmeli and Judith Chassida

    Citation: International Journal for Equity in Health 2020 19:153

    Content type: Research

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  22. Patients with rheumatoid arthritis (RA) represent one of the fragile patient groups that might be susceptible to the critical form of the coronavirus disease − 19 (COVID-19). On the other side, RA patients hav...

    Authors: Mahmood Y. Hachim, Ibrahim Y. Hachim, Kashif Bin Naeem, Haifa Hannawi, Issa Al Salmi and Suad Hannawi

    Citation: Translational Medicine Communications 2020 5:14

    Content type: Research

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  23. Whilst the issues around early termination of randomised controlled trials (RCTs) are well documented in the literature, trials can also be temporarily suspended with the real prospect that they may subsequent...

    Authors: Lynda Constable, Tracey Davidson, Suzanne Breeman, Seonaidh Cotton, Alison McDonald, Samantha Wileman and John Norrie

    Citation: Trials 2020 21:765

    Content type: Commentary

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  24. Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spreads rapidly and has attracted worldwide attention.

    Authors: Shuo Jiang, Qiuyue Li, Chaoqun Li, Shanshan Liu, Xiaomeng He, Tao Wang, Hua Li, Christopher Corpe, Xiaoyan Zhang, Jianqing Xu and Jin Wang

    Citation: Journal of Translational Medicine 2020 18:345

    Content type: Research

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  25. Coronavirus is challenging the global health care system from time to time. The pregnant state, with alterations in hormone levels and decreased lung volumes due to a gravid uterus and slightly immunocompromis...

    Authors: Kuma Diriba, Ephrem Awulachew and Eyob Getu

    Citation: European Journal of Medical Research 2020 25:39

    Content type: Review

    Published on:

  26. Coronavirus disease 2019 outbreak is the first reported case in Wuhan, China in December 2019 and suddenly became a major global health concern. According to the European Centre for Disease Prevention and Cont...

    Authors: Abrha Hailay, Woldu Aberhe, Kidane Zereabruk, Guesh Mebrahtom, Teklehaimanot Haile, Degena Bahrey and Teklewoini Mariye

    Citation: Asthma Research and Practice 2020 6:8

    Content type: Research

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  27. “Immune boosting” is a trending topic during the COVID-19 pandemic. The concept of “immune boosting” is scientifically misleading and often used to market unproven products and therapies. This paper presents a...

    Authors: Darren N. Wagner, Alessandro R. Marcon and Timothy Caulfield

    Citation: Allergy, Asthma & Clinical Immunology 2020 16:76

    Content type: Letter to the editor

    Published on:

  28. Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the first coronavirus disease 2019 (COVID-19) outbreak in China and has become a public health emergency of international concern. SARS-CoV-2 outbrea...

    Authors: Maria Pachetti, Bruna Marini, Fabiola Giudici, Francesca Benedetti, Silvia Angeletti, Massimo Ciccozzi, Claudio Masciovecchio, Rudy Ippodrino and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:338

    Content type: Research

    Published on:

  29. Quarantine/confinement is an effective measure to face the Coronavirus disease 2019 (COVID-19). Consequently, in response to this stressful situation, people confined to their homes may change their everyday e...

    Authors: Chadia Haddad, Maha Zakhour, Maria Bou kheir, Rima Haddad, Myriam Al Hachach, Hala Sacre and Pascale Salameh

    Citation: Journal of Eating Disorders 2020 8:40

    Content type: Research article

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  30. The new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), which was first detected in Wuhan (China) in December of 2019 is responsible for the current global pandemic. Phylogenetic analysis reveale...

    Authors: Francesca Benedetti, Greg A. Snyder, Marta Giovanetti, Silvia Angeletti, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:329

    Content type: Research

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  31. Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients wit...

    Authors: Zhihong Weng, Qiaosen Chen, Sumeng Li, Huadong Li, Qian Zhang, Sihong Lu, Li Wu, Leiqun Xiong, Bobin Mi, Di Liu, Mengji Lu, Dongliang Yang, Hongbo Jiang, Shaoping Zheng and Xin Zheng

    Citation: Journal of Translational Medicine 2020 18:328

    Content type: Research

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  32. In December 2019, pneumonia associated with the 2019 novel coronavirus (COVID-19) emerged in Wuhan, China. The number of cases has increased rapidly. Patients with severe disease have a poor prognosis, and the...

    Authors: Shuaipan Zhang, Qingguang Zhu, Chao Zhan, Wei Cheng, Xiao Mingfang, Min Fang and Lei Fang

    Citation: Trials 2020 21:751

    Content type: Study protocol

    Published on:

  33. The first case of a coronavirus 2019 (COVID-19) infection in a Sri Lankan was reported on March 11, 2020. The situation in Sri Lanka changed with the rapid increase of personnel contracting COVID-19 in a naval...

    Authors: Madunil A. Niriella, Dileepa S. Ediriweera, Arjuna P. De Silva, Ranjan Premarathne, Priyantha Balasooriya, Kaluthanthri D. Duminda, Neelika G. Malavige, Kamani Wanigasuriya, Sarath Lekamwasam, Senanayake A. Kularathne, Sisira Siribaddana, Hithanadura J. de Silva and Saroj Jayasinghe

    Citation: Trials 2020 21:748

    Content type: Study protocol

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  34. Within two decades, there have emerged three highly pathogenic and deadly human coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden and health threats caused by these coronaviruses are...

    Authors: Zhixing Zhu, Xihua Lian, Xiaoshan Su, Weijing Wu, Giuseppe A. Marraro and Yiming Zeng

    Citation: Respiratory Research 2020 21:224

    Content type: Review

    Published on:

  35. COVID-19 is characterized by fast deterioration in the mechanism of cytokine storm. Therefore, treatment with immunomodulating agents should be initiated as soon as hyperinflammation is established. Evidence f...

    Authors: Regina B. Podlasin, Justyna D. Kowalska, Andrzej Pihowicz, Beata Wojtycha-Kwaśnica, Magdalena Thompson, Tomasz Dyda, Hanna Czeszko-Paprocka and Andrzej Horban

    Citation: European Journal of Medical Research 2020 25:37

    Content type: Case report

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  36. The coronavirus disease 2019 (COVID-19) pandemic has led to a declaration of a Public Health Emergency of International Concern by the World Health Organization. As of May 18, 2020, there have been more than 4...

    Authors: Yi Xu, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Jeffrey Xiao, Curtis Lacy, Eric Lau and Huynh Cao

    Citation: Journal of Translational Medicine 2020 18:322

    Content type: Review

    Published on:

  37. This study aims to determine the protection provided by Shenfu injection (a traditional Chinese medicine) against development of organ dysfunction in critically ill patients with coronavirus disease 2019 (COVI...

    Authors: Zong-Yu Wang, Shou-Zhi Fu, Liang Xu, Shu-Sheng Li, Ke-Jian Qian, Xian-Di He, Guo-Chao Zhu, Liang-Hai Li, Jun Zhang, Wen-Fang Li, Bing-Yu Qin, Chen-Liang Zhou and Peng-Lin Ma

    Citation: Trials 2020 21:738

    Content type: Letter

    Published on:

  38. Novel coronavirus disease 2019 presents with fever, dry cough, fatigue, and shortness of breath in most cases; however, some rare manifestations in other organs have also been reported so far.

    Authors: Maryam Heidarpour, Mehrbod Vakhshoori, Saeed Abbasi, Davood Shafie and Nima Rezaei

    Citation: Journal of Medical Case Reports 2020 14:134

    Content type: Case report

    Published on:

  39. In December 2019, an outbreak of coronavirus disease (later named as COVID-19) was identified in Wuhan, China and, later on, detected in other parts of China. Our aim is to evaluate the effectiveness of the ev...

    Authors: Hui Wan, Jing-An Cui and Guo-Jing Yang

    Citation: Infectious Diseases of Poverty 2020 9:116

    Content type: Research Article

    Published on:

  40. Caledonian Stadium, the main mass temporary shelter for homeless people in the City of Tshwane, was created as a local response to the imperatives of the novel coronavirus disease (COVID-19) National State of ...

    Authors: Tessa S. Marcus, Jan Heese, Andrew Scheibe, Shaun Shelly, Sasha X. Lalla and Jannie F. Hugo

    Citation: Harm Reduction Journal 2020 17:60

    Content type: Research

    Published on:

  41. The coronavirus disease 2019 (COVID-19) pandemic may raise unique challenges for individuals with experience of eating disorders. Many factors have potential for detrimental impacts on psychological wellbeing ...

    Authors: Dawn Branley-Bell and Catherine V. Talbot

    Citation: Journal of Eating Disorders 2020 8:44

    Content type: Research article

    Published on:

  42. The emerging infectious disease, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a serious threat in China and worldwide. Challenged by this se...

    Authors: Tie-Long Xu, Mei-Ying Ao, Xu Zhou, Wei-Feng Zhu, He-Yun Nie, Jian-He Fang, Xin Sun, Bin Zheng and Xiao-Fan Chen

    Citation: Infectious Diseases of Poverty 2020 9:115

    Content type: Short Report

    Published on:

  43. The 2019 novel coronavirus disease (COVID-19) has been found in more than 200 countries worldwide since December, 2019. In China, a major reason for the rapid transmission of the COVID-19 in early stage of the...

    Authors: Zi-Han Liu, Yan-Jie Zhao, Yuan Feng, Qinge Zhang, Bao-Liang Zhong, Teris Cheung, Brian J. Hall and Yu-Tao Xiang

    Citation: Globalization and Health 2020 16:75

    Content type: Commentary

    Published on:

  44. COVID 19-related quarantine led to a sudden and radical lifestyle changes, in particular in eating habits. Objectives of the study were to investigate the effect of quarantine on sleep quality (SQ) and body mass ...

    Authors: Luigi Barrea, Gabriella Pugliese, Lydia Framondi, Rossana Di Matteo, Daniela Laudisio, Silvia Savastano, Annamaria Colao and Giovanna Muscogiuri

    Citation: Journal of Translational Medicine 2020 18:318

    Content type: Research

    Published on:

  45. The COVID-19 pandemic has exerted considerable impact on public mental health globally. With the pandemic rapidly rising in sub-Saharan Africa including Kenya, there is need to provide evidence to guide the me...

    Authors: Florence Jaguga and Edith Kwobah

    Citation: International Journal of Mental Health Systems 2020 14:68

    Content type: Review

    Published on: