Skip to main content

Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

Page 4 of 6

  1. Novel coronavirus SARS-CoV-2 is known to be susceptible in vitro to exposure to hydroxychloroquine and its effect has been found to be potentiated by azithromycin. We hypothesise that early administration of h...

    Authors: František Duška, Petr Waldauf, Milada Halačová, Václav Zvoníček, Jakub Bala, Martin Balík, Jan Beneš, Olga Klementová, Irena Kozáková, Viktor Kubricht, Anne Le Roy, Tomáš Vymazal, Veronika Řehořová and Vladimír Černý

    Citation: Trials 2020 21:631

    Content type: Study protocol

    Published on:

  2. The outbreak of coronavirus disease 2019 (COVID-19) is now becoming an enormous threat to public health. The clinical spectrum of COVID-19 is extensive, of which critical cases are with rapid disease progressi...

    Authors: Shan-Yan Zhang, Jiang-Shan Lian, Jian-Hua Hu, Xiao-Li Zhang, Ying-Feng Lu, Huan Cai, Jue-Qing Gu, Chan-Yuan Ye, Ci-Liang Jin, Guo-Dong Yu, Hong-Yu Jia, Yi-Min Zhang, Ji-Fang Sheng, Lan-Juan Li and Yi-Da Yang

    Citation: Infectious Diseases of Poverty 2020 9:85

    Content type: Research Article

    Published on:

  3. Since the outbreak of coronavirus disease 2019 (COVID-19), many researchers in China have performed related clinical research. However, systematic reviews of the registered clinical trials are still lacking. T...

    Authors: Rui-fang Zhu, Yu-lu Gao, Sue-Ho Robert, Jin-ping Gao, Shi-gui Yang and Chang-tai Zhu

    Citation: Journal of Translational Medicine 2020 18:274

    Content type: Review

    Published on:

  4. Previous studies have shown that Coronavirus Disease 2019 (COVID-19) patients with underlying comorbidities can have worse outcomes. However, the effect of hypertension on outcomes of COVID-19 patients remains...

    Authors: Qing Yang, Ying Zhou, Xinrong Wang, Shan Gao, Yang Xiao, Weiming Zhang, Yi Hu and Yafei Wang

    Citation: Respiratory Research 2020 21:172

    Content type: Research

    Published on:

  5. There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in ...

    Authors: Mei-ying Wu, Lin Yao, Yi Wang, Xin-yun Zhu, Xia-fang Wang, Pei-jun Tang and Cheng Chen

    Citation: Respiratory Research 2020 21:171

    Content type: Research

    Published on:

  6. Preliminary reports suggest that the Coronavirus Disease 2019 (COVID− 19) pandemic has led to disproportionate morbidity and mortality among historically disadvantaged populations. We investigate the racial an...

    Authors: Aniruddh P. Patel, Manish D. Paranjpe, Nina P. Kathiresan, Manuel A. Rivas and Amit V. Khera

    Citation: International Journal for Equity in Health 2020 19:114

    Content type: Letter to the Editor

    Published on:

  7. Healthy childhood development is fostered through sufficient physical activity (PA; including time outdoors), limiting sedentary behaviours (SB), and adequate sleep; collectively known as movement behaviours. ...

    Authors: Sarah A. Moore, Guy Faulkner, Ryan E. Rhodes, Mariana Brussoni, Tala Chulak-Bozzer, Leah J. Ferguson, Raktim Mitra, Norm O’Reilly, John C. Spence, Leigh M. Vanderloo and Mark S. Tremblay

    Citation: International Journal of Behavioral Nutrition and Physical Activity 2020 17:85

    Content type: Research

    Published on:

  8. The coronavirus disease 2019 (COVID-19) outbreak has seriously endangered the health and lives of Chinese people. In this study, we predicted the COVID-19 epidemic trend and estimated the efficacy of several i...

    Authors: Jian Zu, Miao-Lei Li, Zong-Fang Li, Ming-Wang Shen, Yan-Ni Xiao and Fan-Pu Ji

    Citation: Infectious Diseases of Poverty 2020 9:83

    Content type: Research Article

    Published on:

  9. The COVID-19 pandemic has had a significant impact on public mental health. Therefore, monitoring and oversight of the population mental health during crises such as a panedmic is an immediate priority. The ai...

    Authors: Nader Salari, Amin Hosseinian-Far, Rostam Jalali, Aliakbar Vaisi-Raygani, Shna Rasoulpoor, Masoud Mohammadi, Shabnam Rasoulpoor and Behnam Khaledi-Paveh

    Citation: Globalization and Health 2020 16:57

    Content type: Research

    Published on:

  10. The rapid spread of the SARS-CoV-2 epidemic has simultaneous time and space dynamics. This behaviour results from a complex combination of factors, including social ones, which lead to significant differences ...

    Authors: Leonardo Azevedo, Maria João Pereira, Manuel C. Ribeiro and Amílcar Soares

    Citation: International Journal of Health Geographics 2020 19:25

    Content type: Methodology

    Published on:

  11. The novel coronavirus disease 2019 (COVID-19) broke out globally. Early prediction of the clinical progression was essential but still unclear. We aimed to evaluate the timeline of COVID-19 development and ana...

    Authors: Fang Wang, Mengyuan Qu, Xuan Zhou, Kai Zhao, Changxiang Lai, Qiyuan Tang, Wenjie Xian, Ruikun Chen, Xuan Li, Zhiyu Li, Qing He and Lei Liu

    Citation: Journal of Translational Medicine 2020 18:270

    Content type: Research

    Published on:

  12. Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of deat...

    Authors: Wenjing Ye, Guoxi Chen, Xiaopan Li, Xing Lan, Chen Ji, Min Hou, Di Zhang, Guangwang Zeng, Yaling Wang, Cheng Xu, Weiwei Lu, Ruolin Cui, Yuyang Cai, Hai Huang and Ling Yang

    Citation: Respiratory Research 2020 21:169

    Content type: Research

    Published on:

  13. The primary objectives of the study are:

    Authors: Raquel González, Laura García-Otero, Clara Pons-Duran, Elena Marbán-Castro, Anna Goncé, Elisa Llurba, Maria del Mar Gil, Miguel Ángel Rodríguez-Zambrano, Haily Chen, Máximo Ramírez, Azucena Bardají and Clara Menendez

    Citation: Trials 2020 21:607

    Content type: Letter

    Published on:

  14. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection beca...

    Authors: Shi-Hui Song, Tie-Long Chen, Li-Ping Deng, Yong-Xi Zhang, Ping-Zheng Mo, Shi-Cheng Gao, Wen-Jia Hu, Yong Xiong and Zhi-Yong Ma

    Citation: Infectious Diseases of Poverty 2020 9:82

    Content type: Case Report

    Published on:

  15. This editorial describes why surge planning in the community must account for potential infection outbreaks in jails and prisons, and why incarcerated people and those in contact with them, including over 450,...

    Authors: Oluwadamilola T. Oladeru, Nguyen-Toan Tran, Tala Al-Rousan, Brie Williams and Nickolas Zaller

    Citation: Health & Justice 2020 8:17

    Content type: Letter to the Editor

    Published on:

  16. There is currently considerable international debate around school closures/openings and the role of children in the transmission of coronavirus disease 2019 (COVID-19). Whilst evidence suggests that children ...

    Authors: Darren J. Gray, Johanna Kurscheid, Mary Lorraine Mationg, Gail M. Williams, Catherine Gordon, Matthew Kelly, Kinley Wangdi and Donald P. McManus

    Citation: Infectious Diseases of Poverty 2020 9:81

    Content type: Opinion

    Published on:

  17. COVID-19, the novel coronavirus affecting the most part of worldwide countries since early 2020, is fast increasing its prevalence around the world, representing a significant emergency for the population and ...

    Authors: Sebastiano Gangemi, Lucia Billeci and Alessandro Tonacci

    Citation: Clinical and Molecular Allergy 2020 18:12

    Content type: Correspondence

    Published on:

  18. In December 2019, 27 cases of pneumonia, of unknown cause, were identified in the province of Hubei (China). The WHO declared the situation as a Public Health Emergency of International Concern, and it was fin...

    Authors: Juan Jose Gonzalez-Gerez, Carlos Bernal-Utrera, Ernesto Anarte-Lazo, Jose Antonio Garcia-Vidal, Jose Martin Botella-Rico and Cleofas Rodriguez-Blanco

    Citation: Trials 2020 21:588

    Content type: Study protocol

    Published on:

  19. Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio...

    Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze

    Citation: Journal of Translational Medicine 2020 18:261

    Content type: Review

    Published on:

  20. This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase.

    Authors: Yiying Huang, Cuiyan Tan, Jian Wu, Meizhu Chen, Zhenguo Wang, Liyun Luo, Xiaorong Zhou, Xinran Liu, Xiaoling Huang, Shican Yuan, Chaolin Chen, Fen Gao, Jin Huang, Hong Shan and Jing Liu

    Citation: Respiratory Research 2020 21:163

    Content type: Research

    Published on:

  21. It is well established that obesity is a disease of sustained low-grade inflammation. However, it is currently unknown if obesity plays a role in the clinical manifestations and prognosis of severe acute respi...

    Authors: Shao-Hang Cai, Wei Liao, Shu-Wei Chen, Li-Li Liu, Si-Yao Liu and Zhi-Dan Zheng

    Citation: Infectious Diseases of Poverty 2020 9:80

    Content type: Research Article

    Published on:

  22. Coronavirus disease 2019 (COVID-19) is now a global public threat. Given the pandemic of COVID-19, the economic impact of COVID-19 is essential to add value to the policy-making process. We retrospectively con...

    Authors: Xue-Zheng Li, Feng Jin, Jian-Guo Zhang, Yun-Feng Deng, Wei Shu, Jing-Min Qin, Xin Ma and Yu Pang

    Citation: Infectious Diseases of Poverty 2020 9:78

    Content type: Research Article

    Published on:

  23. In this study, we investigate the effect of hydroxychloroquine on the prevention of Novel Coronavirus Disease (COVID-19) in cancer patients being treated.

    Authors: Abolghasem Allahyari, Hossein Rahimi, Majid Khadem-Rezaiyan, Zahra Mozaheb, Mohsen Seddigh-Shamsi, Alireza Bary, Mostafa Kamandi, Sajad Ataei Azimi, Saeed Eslami HasanAbadi, Alireza Noferesti, Somayeh Sadat Shariatmaghani, Houshang Rafatpanah, Shohreh Khatami, Afshin Jabbar Imani, Hassan Mortazi and Mohammad Moeini Nodeh

    Citation: Trials 2020 21:575

    Content type: Letter

    Published on:

  24. The COVID-19 is disproportionally affecting the poor, minorities and a broad range of vulnerable populations, due to its inequitable spread in areas of dense population and limited mitigation capacity due to h...

    Authors: Efrat Shadmi, Yingyao Chen, Inês Dourado, Inbal Faran-Perach, John Furler, Peter Hangoma, Piya Hanvoravongchai, Claudia Obando, Varduhi Petrosyan, Krishna D. Rao, Ana Lorena Ruano, Leiyu Shi, Luis Eugenio de Souza, Sivan Spitzer-Shohat, Elizabeth Sturgiss, Rapeepong Suphanchaimat…

    Citation: International Journal for Equity in Health 2020 19:104

    Content type: Commentary

    Published on:

  25. The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease...

    Authors: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind and Howard Kaufman

    Citation: Journal of Translational Medicine 2020 18:257

    Content type: Research

    Published on:

  26. Currently, coronavirus disease 2019 (COVID-19) is continuously and rapidly circulating, causing heavy damage on public health. No effective antiviral treatment has been proved thus far. Traditional Chinese med...

    Authors: Bangjiang Fang, Wen Zhang, Xinxin Wu, Tingrong Huang, Huacheng Li, You Zheng, Jinhua Che, Shuting Sun, Chao Jiang, Shuang Zhou and Jun Feng

    Citation: Trials 2020 21:568

    Content type: Study protocol

    Published on:

  27. During the COVID-19 pandemic, as a large city located in Southwest China, Chengdu was mainly affected by imported cases. For a psychiatric hospital, the enclosed management model, the crowded wards and the unc...

    Authors: Jiajia Chen, Maoxiang Xiong, Zongling He, Wen Shi, Yuchuan Yue and Manxi He

    Citation: Globalization and Health 2020 16:53

    Content type: Letter to the Editor

    Published on:

  28. With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat...

    Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella

    Citation: Journal of Translational Medicine 2020 18:251

    Content type: Research

    Published on:

  29. As COVID-19 makes its way around the globe, each nation must decide when and how to respond. Yet many knowledge gaps persist, and many countries lack the capacity to develop complex models to assess risk and r...

    Authors: Lei Zhou, Jiang-Mei Liu, Xiao-Ping Dong, Jennifer M. McGoogan and Zun-You Wu

    Citation: Infectious Diseases of Poverty 2020 9:76

    Content type: Research Article

    Published on:

  30. Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.

    Authors: Changzhi Zhou, Zhe Huang, Weijun Tan, Xueying Li, Wen Yin, Yang Xiao, Zhaowu Tao, Shuang Geng and Yi Hu

    Citation: Respiratory Research 2020 21:157

    Content type: Research

    Published on:

  31. Electronic cigarette (e-cig) vaping is increasing rapidly in the United States, as e-cigs are considered less harmful than combustible cigarettes. However, limited research has been conducted to understand the...

    Authors: Qixin Wang, Isaac K. Sundar, Dongmei Li, Joseph H. Lucas, Thivanka Muthumalage, Samantha R. McDonough and Irfan Rahman

    Citation: Respiratory Research 2020 21:154

    Content type: Research

    Published on:

  32. Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In t...

    Authors: Giacomo Malipiero, Enrico Heffler, Corrado Pelaia, Francesca Puggioni, Francesca Racca, Sebastian Ferri, Lina Spinello, Morena Merigo, Donatella Lamacchia, Giuseppe Cataldo, Melissa Sansonna, Giorgio Walter Canonica and Giovanni Paoletti

    Citation: Clinical and Translational Allergy 2020 10:23

    Content type: Review

    Published on:

  33. At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with disastrous consequences for people of all countr...

    Authors: Xiaofeng Ruan, Peng Du, Kang Zhao, Jucun Huang, Hongmei Xia, Dan Dai, Shu Huang, Xiang Cui, Liming Liu and Jianjun Zhang

    Citation: Chinese Medicine 2020 15:62

    Content type: Research

    Published on:

  34. A possible association could exist between type 2 diabetes mellitus (T2DM) and Coronavirus-19 (Covid-19) infection. Indeed, patients with T2DM show high prevalence, severity of disease and mortality during Cov...

    Authors: Celestino Sardu, Giuseppe Gargiulo, Giovanni Esposito, Giuseppe Paolisso and Raffaele Marfella

    Citation: Cardiovascular Diabetology 2020 19:76

    Content type: Commentary

    Published on:

  35. The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and hydroxychloroquine via anti-inflammation/immune modulation, antiviral efficacy and...

    Authors: Pradeesh Sivapalan, Charlotte Suppli Ulrik, Rasmus Dahlin Bojesen, Therese Sophie Lapperre, Josefin Viktoria Eklöf, Kjell Erik Julius Håkansson, Andrea Browatzki, Casper Tidemansen, Jon Torgny Wilcke, Julie Janner, Vibeke Gottlieb, Howraman Meteran, Celeste Porsbjerg, Birgitte Lindegaard Madsen, Mia Moberg, Lars Pedersen…

    Citation: Trials 2020 21:513

    Content type: Letter

    Published on:

    The Update to this article has been published in Trials 2020 21:867

  36. Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen...

    Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Ippolito

    Citation: Journal of Translational Medicine 2020 18:233

    Content type: Research

    Published on:

  37. The purpose of this study is to report the clinical features and outcomes of Black/African American (AA) and Latino Hispanic patients with Coronavirus disease 2019 (COVID-19) hospitalized in an inter-city hosp...

    Authors: Alexis K. Okoh, Christoph Sossou, Neha S. Dangayach, Sherin Meledathu, Oluwakemi Phillips, Corinne Raczek, Michael Patti, Nathan Kang, Sameer A. Hirji, Charles Cathcart, Christian Engell, Marc Cohen, Sandhya Nagarakanti, Eliahu Bishburg and Harpreet S. Grewal

    Citation: International Journal for Equity in Health 2020 19:93

    Content type: Research

    Published on:

  38. Although research on the effects of comorbidities on coronavirus disease 2019 (COVID-19) patients is increasing, the risk of cancer history has not been evaluated for the mortality of patients with COVID-19.

    Authors: Yifan Meng, Wanrong Lu, Ensong Guo, Jia Liu, Bin Yang, Ping Wu, Shitong Lin, Ting Peng, Yu Fu, Fuxia Li, Zizhuo Wang, Yuan Li, Rourou Xiao, Chen Liu, Yuhan Huang, Funian Lu…

    Citation: Journal of Hematology & Oncology 2020 13:75

    Content type: Research

    Published on:

  39. On December 12th 2019, a new coronavirus (SARS-Cov2) emerged in Wuhan, China, sparking a pandemic of acute respiratory syndrome in humans (COVID-19). On the 24th of April 2020, the number of COVID-19 deaths in...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Giulia Cinelli, Claudia Leggeri, Giovanna Caparello, Luigi Barrea, Francesco Scerbo, Ernesto Esposito and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2020 18:229

    Content type: Research

    Published on:

  40. SARS-CoV-2 began spreading in December 2019 and has since become a pandemic that has impacted many aspects of human society. Several issues concerning the origin, time of introduction to humans, evolutionary p...

    Authors: Shu-Miaw Chaw, Jui-Hung Tai, Shi-Lun Chen, Chia-Hung Hsieh, Sui-Yuan Chang, Shiou-Hwei Yeh, Wei-Shiung Yang, Pei-Jer Chen and Hurng-Yi Wang

    Citation: Journal of Biomedical Science 2020 27:73

    Content type: Research

    Published on:

  41. On December 31, 2019, the World Health Organization was alerted to the occurrence of cases of pneumonia in Wuhan, Hubei Province, China, that were caused by an unknown virus, which was later identified as a co...

    Authors: Soyoung Kim, Sunhwa Choi, Youngsuk Ko, Moran Ki and Eunok Jung

    Citation: Theoretical Biology and Medical Modelling 2020 17:9

    Content type: Research

    Published on:

  42. On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious...

    Authors: Feng-Yee Chang, Hsiang-Cheng Chen, Pei-Jer Chen, Mei-Shang Ho, Shie-Liang Hsieh, Jung-Chung Lin, Fu-Tong Liu and Huey-Kang Sytwu

    Citation: Journal of Biomedical Science 2020 27:72

    Content type: Review

    Published on:

  43. COVID-19 has rapidly spread all over the world, progressing into a pandemic. This situation has urgently impelled many companies and public research institutes to concentrate their efforts on research for effe...

    Authors: Giovanni Salvatori, Laura Luberto, Mariano Maffei, Luigi Aurisicchio, Giuseppe Roscilli, Fabio Palombo and Emanuele Marra

    Citation: Journal of Translational Medicine 2020 18:222

    Content type: Commentary

    Published on:

  44. Healthcare simulation has significant potential for helping health services to deal with the COVID-19 pandemic. Rapid changes to care pathways and processes needed for protection of staff and patients may be f...

    Authors: Victoria Brazil, Belinda Lowe, Leanne Ryan, Rachel Bourke, Clare Scott, Simone Myers, Hellen Kaneko, Jane Schweitzer and Brenton Shanahan

    Citation: Advances in Simulation 2020 5:9

    Content type: Innovation

    Published on: