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Extracellular Vesicles in Intercellular Communication

Cell Communications and Signaling invites you to submit to our new thematic series:

Extracellular Vesicles in Intercellular Communication

Virtually all living organisms continuously release extracellular vesicles (EVs) such as exosomes, microvesicles or other nano-sized EVs into their environment. By shuttling communication-competent cargo including nucleic acids, proteins, lipids, or secondary messengers they modulate fate und function of recipient cells, tissues and organisms. EV-mediated cell communication is therefore increasingly recognized to play an essential role in both, health and disease.

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Current developments in the field of extracellular vesicles will be presented by experts at the joint annual meeting of the Austrian and German Societies of Extracellular Vesicles (ASEV/GSEV) and the Extracellular Vesicles Theralytic Technologies Center (EVTT), "Small New World", taking place in Salzburg, Austria from October 28-29, 2022.
Extracellular vesicles TS image 2

This new thematic CCS series will focus on the role of EVs in intercellular communication and their potential biomedical applications, and aims to highlight contributions from the Small New World 2022 conference.

We welcome the submission of manuscripts that describe the functional roles of extracellular vesicles in intercellular communication, as well as technological advances to study EVs.

Guest Editors: Nicole Meisner-Kober and Silja Wessler, Paris-Lodron University Salzburg

Submission Deadline: This collection is closed to submissions. 

  1. Cell-to-cell communication is vital for tissues to respond, adapt, and thrive in the prevailing milieu. Several mechanisms mediate intercellular signaling, including tunneling nanotubes, gap junctions, and ext...

    Authors: Michael L. Risner, Marcio Ribeiro, Nolan R. McGrady, Bhanu S. Kagitapalli, Xitiz Chamling, Donald J. Zack and David J. Calkins
    Citation: Cell Communication and Signaling 2023 21:305
    Content type: Research Published on:

  2. E. coli O83 (Colinfant Newborn) is a Gram-negative (G-) probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration offer...

    Authors: Anna Marlene Schmid, Agnieszka Razim, Magdalena Wysmołek, Daniela Kerekes, Melissa Haunstetter, Paul Kohl, Georgii Brazhnikov, Nora Geissler, Michael Thaler, Eliška Krčmářová, Martin Šindelář, Tamara Weinmayer, Jiří Hrdý, Katy Schmidt, Peter Nejsum, Bradley Whitehead…
    Citation: Cell Communication and Signaling 2023 21:297
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:349

  3. Exosomes are small extracellular vesicles that play important roles in intercellular communication and have potential therapeutic applications in regenerative medicine. Dermal mesenchymal stem cells (DMSCs) ar...

    Authors: Ying-Hao Han, Ying-Ying Mao, Kyung Ho Lee, Hee Jun Cho, Nan-Nan Yu, Xiao-Ya Xing, Ai-Guo Wang, Mei-Hua Jin, Kwan Soo Hong, Hu-Nan Sun and Taeho Kwon
    Citation: Cell Communication and Signaling 2023 21:296
    Content type: Research Published on:

  4. Macrophage filopodia, which are dynamic nanotube-like protrusions, have mainly been studied in the context of pathogen clearance. The mechanisms by which they facilitate intercellular communication and mediate...

    Authors: Xiaodong Zhu, Yu Zhao, Yuqiu Liu, Wen Shi, Junlan Yang, Zhihong Liu and Xiaoliang Zhang
    Citation: Cell Communication and Signaling 2023 21:293
    Content type: Research Published on:

  5. Extracellular vesicles (EVs) originating from the central nervous system (CNS) can enter the blood stream and carry molecules characteristic of disease states. Therefore, circulating CNS-derived EVs have the p...

    Authors: Alexandra Brahmer, Carsten Geiß, Andriani Lygeraki, Elmo Neuberger, Theophilos Tzaridis, Tinh Thi Nguyen, Felix Luessi, Anne Régnier-Vigouroux, Gunther Hartmann, Perikles Simon, Kristina Endres, Stefan Bittner, Katrin S. Reiners and Eva-Maria Krämer-Albers
    Citation: Cell Communication and Signaling 2023 21:276
    Content type: Research Published on:

  6. Innate immunity is the first line of the host immune system to fight against infections. Natural killer cells are the innate immunity lymphocytes responsible for fighting against virus-infected and cancerous c...

    Authors: Mohammad Hossein Razizadeh, Alireza Zafarani, Mahsa Taghavi-Farahabadi, Hossein Khorramdelazad, Sara Minaeian and Mohammad Mahmoudi
    Citation: Cell Communication and Signaling 2023 21:261
    Content type: Review Published on:

  7. Apoptotic vesicles are extracellular vesicles generated by apoptotic cells that were previously regarded as containing waste or harmful substances but are now thought to play an important role in signal transd...

    Authors: Xianghui Zou, Qian Lei, Xinghong Luo, Jingyao Yin, Shuoling chen, Chunbo Hao, Liu Shiyu and Dandan Ma
    Citation: Cell Communication and Signaling 2023 21:260
    Content type: Review Published on:

  8. Exosomes are a new class of molecular entities in the metastatic microenvironment, which can mediate bidirectional communication between cells. While exosomes-mediated interactions between tumor cells and othe...

    Authors: Lei Shi, Bowen Li, Yuhan Zhang, Yuting Chen, Jiyu Tan, Yan Chen, Jie Li, Meng Xiang, H. Rosie Xing and Jianyu Wang
    Citation: Cell Communication and Signaling 2023 21:248
    Content type: Research Published on:

  9. Traumatic brain injury (TBI) is a leading cause of injury-related disability and death around the world, but the clinical stratification, diagnosis, and treatment of complex TBI are limited. Due to their uniqu...

    Authors: Xinlong Dong, Jing-fei Dong and Jianning Zhang
    Citation: Cell Communication and Signaling 2023 21:211
    Content type: Review Published on:

  10. Extracellular vesicles (EVs) are membrane-coated nanoparticles secreted by almost all cell types in living organisms. EVs, as paracrine mediators, are involved in intercellular communication, immune response, ...

    Authors: Maria M. Guzewska, Kamil Myszczynski, Yael Heifetz and Monika M. Kaczmarek
    Citation: Cell Communication and Signaling 2023 21:210
    Content type: Research Published on:

  11. Endothelial glycocalyx (EG) is an active player and treatment target in inflammatory-related vascular leakage. The bone marrow mesenchymal stem cells (bMSCs) are promising potential treatments for leakage; how...

    Authors: Zhe Li, Yuqing Xu, Shiyue Lu, Yuan Gao and Yuxiao Deng
    Citation: Cell Communication and Signaling 2023 21:205
    Content type: Research Published on:

  12. Extracellular vesicles (EVs) harbor a plethora of different biomolecules, which they can transport across cells. In cancer, tumor-derived EVs thereby support the creation of a favorable tumor microenvironment....

    Authors: Barnabas Irmer, Janes Efing, Lea Elisabeth Reitnauer, Allegra Angenendt, Saskia Heinrichs, Antonia Schubert, Matthias Schulz, Claudia Binder, Joke Tio, Uwe Hansen, Christiane Geyer, Mirjam Gerwing, Annalen Bleckmann and Kerstin Menck
    Citation: Cell Communication and Signaling 2023 21:171
    Content type: Research Published on:

  13. Multiple studies have shown that extracellular vesicles (EVs) play a key role in the process of information transfer and material transport between cells. EVs are classified into different types according to t...

    Authors: Xiaoyu Fu, Junlong Song, Wei Yan, Bradley M. Downs, Weixing Wang and Juanjuan Li
    Citation: Cell Communication and Signaling 2023 21:150
    Content type: Review Published on:

  14. Blood–brain barrier (BBB) interface with multicellular structure controls strictly the entry of varied circulating macromolecules from the blood-facing surface into the brain parenchyma. Under several patholog...

    Authors: Leila Salimi, Fatemehsadat Seyedaghamiri, Mohammad Karimipour, Halimeh Mobarak, Narges Mardi, Maryam Taghavi and Reza Rahbarghazi
    Citation: Cell Communication and Signaling 2023 21:118
    Content type: Review Published on:

  15. Extracellular vesicles (EVs) from Gram-positive bacteria have gained considerable importance as a novel transport system of virulence factors in host–pathogen interactions. Bacillus cereus is a Gram-positive huma...

    Authors: Tanja Buchacher, Astrid Digruber, Markus Kranzler, Giorgia Del Favero and Monika Ehling-Schulz
    Citation: Cell Communication and Signaling 2023 21:112
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2024 22:37

  16. Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) a...

    Authors: Katrin Laakmann, Jorina Mona Eckersberg, Moritz Hapke, Marie Wiegand, Jeff Bierwagen, Isabell Beinborn, Christian Preußer, Elke Pogge von Strandmann, Thomas Heimerl, Bernd Schmeck and Anna Lena Jung
    Citation: Cell Communication and Signaling 2023 21:111
    Content type: Research Published on:

  17. Migrasomes are newly discovered extracellular vesicles (EVs) that are formed in migrating cells and mediate intercellular communication. However, their size, biological generation, cargo packaging, transport, ...

    Authors: Yuyun Jiang, Xi Liu, Jixian Ye, Yongbin Ma, Jiahui Mao, Dingqi Feng and Xuefeng Wang
    Citation: Cell Communication and Signaling 2023 21:105
    Content type: Review Published on:

  18. Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transp...

    Authors: Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N. Schulte, Stefan Bauer, Elke Pogge von Strandmann…
    Citation: Cell Communication and Signaling 2023 21:65
    Content type: Research Published on:

  19. Recent advances in extracellular vesicle (EVs) detection and isolation methods have led to the development of novel therapeutic modalities. Among different types of EVs, exosomes (Exos) can transfer different ...

    Authors: Morteza Heidarzadeh, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu
    Citation: Cell Communication and Signaling 2023 21:64
    Content type: Review Published on:

  20. Viruses must adapt to the environment of their host cells to establish infection and persist. Diverse mammalian cells, including virus-infected cells, release extracellular vesicles such as exosomes containing...

    Authors: Yoshitaka Sato, Masahiro Yaguchi, Yusuke Okuno, Hanako Ishimaru, Ken Sagou, Somi Ozaki, Takeshi Suzuki, Tomoki Inagaki, Miki Umeda, Takahiro Watanabe, Masahiro Fujimuro, Takayuki Murata and Hiroshi Kimura
    Citation: Cell Communication and Signaling 2022 20:95
    Content type: Research Published on: