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Call for papers - Organoids as models of development and disease

Guest Editor

Sérgio Paulo Bydlowski, MD, MSci, PhD, University of São Paulo, Brazil

Submission Status: Open   |   Submission Deadline: 1 August 2024

BMC Molecular and Cell Biology invites submissions to our new Collection, Organoids as models of development and disease. This Collection emphasizes the use of patient-derived organoids for disease modeling and diagnostics, and advancements in generating and maintaining organoids. We also hope to highlight their role in unraveling early developmental stages, the generation and improvement of induced pluripotent stem cell-derived organoids, and their applications in personalized medicine.

Meet the Guest Editor

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Sérgio Paulo Bydlowski, MD, MSci, PhD, Associate Professor of Hematology, Hemotherapy and Cell Therapy, University of São Paulo School of Medicine, Brazil

Dr Bydlowski graduated with a degree in Medicine from Santa Casa de São Paulo and holds advanced degrees in Molecular Biology from the Escola Paulista de Medicina (UNIFESP). Further, he holds postdoctoral degrees from the University of Cincinnati School of Medicine and the Karolinska Institute. Currently an Associate Professor of Hematology, Hemotherapy, and Cell Therapy at the University of São Paulo (FMUSP), Dr Bydlowski leads significant research initiatives including the "Organoid Development" group at the Institute of Physics. He has a robust publication record, with over 150 scientific articles and 100 book chapters, both domestically and internationally. He is a member of the editorial board of BMC Molecular and Cell Biology.

About the Collection

Advancements in cell culture and reprogramming technologies have allowed an increased use of organoids to study a variety of biological processes. The use of stem cell-derived organoids provides three-dimensional in vitro cellular models which accurately recapitulate features of complex multicellular organs and early stages of development. Increasingly, organoids are also being used to understand a range of human diseases, from infectious diseases to noncommunicable diseases.

Advances in induced pluripotent stem cell (iPSC) technologies are allowing researchers to establish iPSC-derived organoids from patient biopsies. These organoids will not only allow to investigate the causes and development of diseases but will also pave way to develop and test new therapeutics. Furthermore, the use of patient biopsy samples to generate organoids will be invaluable in developing personalized treatment or understanding rare genetic disorders. Importantly, progress in organoid technology will also reduce our need to rely on animal models, which often poorly recapitulate human disease. 

Given the importance of the field, BMC Molecular and Cell Biology would like to invite submissions to our new Collection. Topics of interest include, but are not limited to, the following:

  • Use of patient-derived organoids to model human disease
  • Development of methods to generate and maintain organoids
  • Methods to improve complexity of multicellular organoids
  • The use of organoids to understand early development stages
  • Generation of iPSCs and iPSC-derived organoids and improvement of reprogramming technologies 
  • Use of organoids to understand responses to diseases 
  • Use of organoids in Personalized Medicine
  • Organoids and development of new therapeutic agents

Image credit: Dr. Torsten Wittmann / Science Photo Library

  1. Emerging evidence underscores the responsiveness of the mammalian intestine to dietary cues, notably through the involvement of LGR5 + intestinal stem cells in orchestrating responses to diet-driven signals. H...

    Authors: Itsuma Nagao and Yoko M. Ambrosini
    Citation: BMC Molecular and Cell Biology 2024 25:14

Submission Guidelines

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This Collection welcomes submission of original Research Articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Organoids as models of development and disease" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.