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Mesenchymal stem cells in disease development and therapy

Edited by
Zhipeng Han
Lixin Wei

Mesenchymal stem cells (MSCs) are emerging as a promising therapeutic approach of cell-based therapy for a wide range of autoimmune disorders and degenerative diseases due to their ability of multi-differentiation and inflammation regulation.

This Cell & Bioscience thematic series showcases a collection of Primary Research Articles and Reviews that provide a valuable overview of when and how MSCs involved in the development of the disease can further our understanding of the biological function of MSCs, as well as MSCs-based new strategy for treatment diseases.

Topics to be covered include (but are not limited to):

- Role of MSCs in immune disorder diseases

- Role of MSCs in tissue regeneration

- Interplay between MSCs and inflammatory microenvironment

- Role of MSCs in tumor progress

- Current advancement on MSCs application in disease therapy

  1. Mesenchymal stem cells (MSCs) have been proved to drive castration resistant prostate cancer (CRPC). In this study, we aim to investigate the contribution of MSCs to the development of docetaxel resistance in ...

    Authors: Yang Yu, Fu-han Yang, Wen-tao Zhang, Ya-dong Guo, Lin Ye and Xu-dong Yao
    Citation: Cell & Bioscience 2021 11:7
  2. Mesenchymal stem cells (MSCs) represent a promising treatment option for acute kidney injury (AKI). The main drawbacks of MSCs therapy, including the lack of specific homing after systemic infusion and early c...

    Authors: Song Zhou, Yu-ming Qiao, Yong-guang Liu, Ding Liu, Jian-min Hu, Jun Liao, Min Li, Ying Guo, Li-pei Fan, Liu-Yang Li and Ming Zhao
    Citation: Cell & Bioscience 2020 10:130
  3. Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells or mesenchymal stromal cells, are present in multiple tissues and capable of differentiating into diverse cell lineages, holding a g...

    Authors: Yizhen Sima and Yisong Chen
    Citation: Cell & Bioscience 2020 10:104
  4. Patients with type 2 diabetes mellitus (T2DM), especially those with poor glycemic control, are characterized by low bone mass and destruction of bone microstructure. Nowadays, autologous mesenchymal stem cell...

    Authors: Lei Wang, Shaojie Shi, Ruiping Bai, Yue Wang, Zhao Guo and Doudou Li
    Citation: Cell & Bioscience 2020 10:102
  5. Cancer stem cells are the main reason of relapse, metastasis and resistance to anti-cancer therapies of Hepatocellular carcinoma (HCC). Mesenchymal stem cells (MSCs) are an important part of the tumor microenv...

    Authors: Jing Hou, Naping Zhao, Pengxi Zhu, Jun Chang, Yan Du and Wei Shen
    Citation: Cell & Bioscience 2020 10:93
  6. Mesenchymal stem/stromal cells (MSCs) and macrophages are critical components in many tissue microenvironments, including that in adipose tissue. The close interaction between MSCs and macrophages modulates va...

    Authors: Hui Ma, Ya-nan Li, Lin Song, Rui Liu, Xiaolei Li, Qianwen Shang, Ying Wang, Changshun Shao and Yufang Shi
    Citation: Cell & Bioscience 2020 10:88
  7. Interleukin-17A (IL-17) is an evolutionary conserved cytokine and best known for its role in boosting immune response. However, recent clinical researches showed that abundant IL-17 in tumor microenvironment w...

    Authors: Shijia Wang, Guan Wang, Liying Zhang, Fengying Li, Keli Liu, Ying Wang, Yufang Shi and Kai Cao
    Citation: Cell & Bioscience 2020 10:73
  8. Acute Liver failure (ALF) is a life-threatening disease and is determined by coagulopathy (with INR ≥ 1.5) and hepatic encephalopathy as a result of severe liver injury in patients without preexisting liver di...

    Authors: Mahshid Saleh, Mohammad Taher, Amir Ali Sohrabpour, Amir Abbas Vaezi, Mohsen Nasiri Toosi, Maria Kavianpour, Zeinab Ghazvinian, Shahrokh Abdolahi and Javad Verdi
    Citation: Cell & Bioscience 2020 10:71
  9. Mesenchymal stem cells (MSCs) were known to have excellent properties in cell therapy. However, the risk of immune rejection associated with cell transplant therapy hampers its use. Extracellular vesicles secr...

    Authors: Jiaxin Cai, Junyong Wu, Jiemin Wang, Yongjiang Li, Xiongbin Hu, Shifu Luo and Daxiong Xiang
    Citation: Cell & Bioscience 2020 10:69
  10. Mesenchymal stromal cells (MSCs) are multiple stromal cells existing in various tissues and have already been employed in animal models and clinical trials to treat immune disorders through potent immunosuppre...

    Authors: Menghui Jiang, Jiayin Ye, Xuefeng Wang, Na Li, Ying Wang and Yufang Shi
    Citation: Cell & Bioscience 2020 10:65