BMC Cancer has published this Collection on pre-clinical cancer models.
Cancer models are indispensable research tools, as they help elucidating the mechanisms involved in tumour onset and progression, leading to the development of new therapeutic treatments. While widely-used conventional two-dimensional cell models have been the gold standard for many decades, some of their main limitations include the lack of representation of the stromal population, the absence of a three-dimensional structure, and a poor representation of inter-tumour and intra-tumour heterogeneity. Therefore, a multitude of novel cancer models are emerging, which can advance the understanding of tumour pathophysiology and behavior. This will ultimately help improving patients’ clinical outcomes, through the introduction of more personalized and targeted treatments in the clinical setting.
In recognition of the growing field of research, BMC Cancer welcomed submissions to this collection ‘Advances in pre-clinical cancer models’. Topics of interest for this special issue included:
- Scaffold-based in vitro models
- 3D cell cultures
- Co-culture settings
- Tumour organoids
- Large and small animal models
- Genetically engineered cell lines and animal models
- Chemically induced tumour models
- Xenotransplantation models (Patient derived xenografts, cell-line derived xenograft)
- Allotransplantation models
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