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Cancer Metabolism

New Content ItemGuest Editors: Navdeep Chandel, Matthew Vander Heiden, Karen Vousden, Kathryn Wellen

Cancer cells have unique metabolic and bioenergetic properties, allowing them to thrive in nutrient poor environments and maximize cell growth and proliferation. Myriad inputs feed into the metabolism of cancer and cancer-associated cells; as well as interactions within the tumor microenvironment. Understanding the flexibility of changes in the metabolic program, and the underlying mechanisms, will be key in developing new therapeutic approaches.

In this series, BMC Biology and Cancer & Metabolism bring together commissioned Reviews and Research of exceptional interest, highlighting advances in our understanding of cancer metabolism.

The special issue is guest edited by Navdeep Chandel (Northwestern University, USA), Matthew Vander Heiden (Massachusetts Institute of Technology, USA), Karen Vousden (The Francis Crick Institute, UK), and Kathryn Wellen (University of Pennsylvania, USA).

Image adapted from: Bruce Wetzel and Harry Schaefer, National Cancer Institute, National Institutes of Health.

  1. This review discusses the current state of the viral metabolism field and gaps in knowledge that will be important for future studies to investigate. We discuss metabolic rewiring caused by viruses, the influe...

    Authors: Shivani K. Thaker, James Ch’ng and Heather R. Christofk

    Citation: BMC Biology 2019 17:59

    Content type: Review

    Published on:

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    Authors: Sarah-Maria Fendt

    Citation: BMC Biology 2019 17:54

    Content type: Question and Answer

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  3. Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically ne...

    Authors: Payam A. Gammage and Christian Frezza

    Citation: BMC Biology 2019 17:53

    Content type: Review

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  4. Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. Ho...

    Authors: Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib and Margaret Ashcroft

    Citation: Cancer & Metabolism 2019 7:2

    Content type: Research

    Published on: