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Towards malaria elimination

The launch of a new thematic series of Malaria Journal, "Towards malaria elimination", creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic settings and conditions into the circles of scientists, public health specialists, national and global programme managers, funders and decision makers.

"Towards malaria elimination" welcomes original papers, reviews, commentaries and opinion pieces on malaria elimination and eradication, and hopes that this mix of scientific information and debate will catalyze and dynamize the move towards more intensified control and progressively malaria elimination within a spirit of mutual learning for change. The Editors very much hope that many scientists, public health professionals and policy makers will start using "Towards malaria elimination" as one of their ways to share new evidence or to discuss evidence presented in the scientific literature.

View all collections published in Malaria Journal.

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  1. Rapid diagnostic tests (RDTs) play a significant role in expanding case management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen detection RDTs are predominantly used to diagnose Plasm...

    Authors: Bacha Mekonen, Sisay Dugassa, Sindew Mekasha Feleke, Boja Dufera, Bedasa Gidisa, Aderaw Adamu, Aynalem Mandefro, Geremew Tasew and Lemu Golassa
    Citation: Malaria Journal 2024 23:108
    Content type: Research Published on:

  2. In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic diversit...

    Authors: Alex Mwesigwa, Moses Ocan, Benson Musinguzi, Rachel Wangi Nante, Joaniter I. Nankabirwa, Steven M. Kiwuwa, Alison Annet Kinengyere, Barbara Castelnuovo, Charles Karamagi, Ekwaro A. Obuku, Samuel L. Nsobya, Sam M. Mbulaiteye and Pauline Byakika-Kibwika
    Citation: Malaria Journal 2024 23:97
    Content type: Review Published on:

  3. Malaria remains a public health problem in regions of Northeastern India because of favourable bio-geographic transmission conditions, poor access to routine healthcare, and inadequate infrastructure for publi...

    Authors: Carinthia B. Nengnong, Mattimi Passah, Mark L. Wilson, Elisa Bellotti, Anne Kessler, Bibha R. Marak, Jane M. Carlton, Rajiv Sarkar and Sandra Albert
    Citation: Malaria Journal 2024 23:83
    Content type: Research Published on:

  4. Vegetation health (VH) is a powerful characteristic for forecasting malaria incidence in regions where the disease is prevalent. This study aims to determine how vegetation health affects the prevalence of mal...

    Authors: Gouvidé Jean Gbaguidi, Mouhamed Idrissou, Nikita Topanou, Walter Leal Filho and Guillaume K. Ketoh
    Citation: Malaria Journal 2024 23:78
    Content type: Research Published on:

  5. Pyrethroid-based indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) have been employed as key vector control measures against malaria in Namibia. However, pyrethroid resistance in Anopheles

    Authors: Rosalia N. Joseph, Tabeth Mwema, Seth J. Eiseb, Deodatus V. Maliti, Munyaradzi Tambo, Iitula Iitula, Lydia Eloff, Ophilia Lukubwe, Cara Smith-Gueye, Élodie A. Vajda, Allison Tatarsky, Stark T. Katokele, Petrina N. Uusiku, Dennis Walusimbi, Sheila B. Ogoma, Davis R. Mumbengegwi…
    Citation: Malaria Journal 2024 23:77
    Content type: Research Published on:

  6. Genetic surveillance of the Plasmodium falciparum parasite shows great promise for helping National Malaria Control Programmes (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polyge...

    Authors: Wesley Wong, Stephen F. Schaffner, Julie Thwing, Mame Cheikh Seck, Jules Gomis, Younouss Diedhiou, Ngayo Sy, Medoune Ndiop, Fatou Ba, Ibrahima Diallo, Doudou Sene, Mamadou Alpha Diallo, Yaye Die Ndiaye, Mouhamad Sy, Aita Sene, Djiby Sow…
    Citation: Malaria Journal 2024 23:68
    Content type: Research Published on:

  7. The malaria incidence data from a malaria prevention study from the Rift Valley, Central Ethiopia, were reanalysed. The objective was to investigate whether including an administrative structure within the soc...

    Authors: Taye Gari and Bernt Lindtjørn
    Citation: Malaria Journal 2024 23:67
    Content type: Research Published on:

  8. Malaria elimination requires closely co-ordinated action between neighbouring countries. In Southern Africa several countries have reduced malaria to low levels, but the goal of elimination has eluded them thu...

    Authors: Chadwick H. Sikaala, Bongani Dlamini, Alphart Lungu, Phelele Fakudze, Mukosha Chisenga, Chishala Lukwesa Siame, Nyasha Mwendera, Dumisani Shaba, John M. Chimumbwa and Immo Kleinschmidt
    Citation: Malaria Journal 2024 23:62
    Content type: Case Study Published on:

    The Correction to this article has been published in Malaria Journal 2024 23:98

  9. By 2022, the Government of Indonesia had successfully eliminated malaria in 389 out of 514 districts but continues to face a challenge in Eastern Indonesia where 95% of the total 2021 malaria cases were report...

    Authors: Dee Jupp, Sherria Ayuandini, Frisca Tobing, Denny Halim, Enny Kenangalem, Maria E. Sumiwi, Hellen D. Prameswari, Minerva Theodora, Hermawan Susanto, Riskha T. P. Dewi, Dedy Supriyanto, Bayu Kurnia, Mrunal Shetye, Ermi Ndoen and Yuka Onishi
    Citation: Malaria Journal 2024 23:59
    Content type: Research Published on:

  10. Gabon still bears significant malaria burden despite numerous efforts. To reduce this burden, policy-makers need strategies to design effective interventions. Besides, malaria distribution is well known to be ...

    Authors: Fabrice Mougeni, Bertrand Lell, Ngianga-Bakwin Kandala and Tobias Chirwa
    Citation: Malaria Journal 2024 23:57
    Content type: Research Published on:

  11. Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over the last two decades. Successful implementation of MDA programmes requires community participation and can be threa...

    Authors: Christian Kositz, Hristina Vasileva, Nuredin Mohammed, Jane Achan, Edgard Diniba Dabira, Umberto D’Alessandro, John Bradley and Michael Marks
    Citation: Malaria Journal 2024 23:54
    Content type: Research Published on:

  13. Malaria remains an enduring public health concern in Indonesia, exacerbated by its equatorial climate that fosters the proliferation of Anopheles mosquitoes. This study seeks to assess the performance of the mala...

    Authors: Hamzah Hasyim, Heni Marini, Misnaniarti Misnaniarti, Rostika Flora, Iche Andriyani Liberty, Ahmed Elagali, Hartoni Hartoni and Fadhilah Eka Maharani
    Citation: Malaria Journal 2024 23:43
    Content type: Research Published on:

  14. The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this resid...

    Authors: Lepa Syahrani, Puji B. S. Asih, Anom Bowolaksono, Astari Dwiranti, Siti Zubaidah, Ismail E. Rozi, Dendi H. Permana, Claus Bøgh, Michael J. Bangs, John P. Grieco, Nicole L. Achee, Neil F. Lobo and Din Syafruddin
    Citation: Malaria Journal 2024 23:31
    Content type: Research Published on:

  15. Malaria remains a significant public health concern in Niger, with the number of cases increasing from 592,334 in 2000 to 3,138,696 in 2010. In response, a concerted campaign against the disease has been initi...

    Authors: Ali Issakou Malam Tchole, Run-Ze Ye, Qing Xu, Zhen-Wei Li, Jin-Yue Liu, Shan-Shan Wang, Jing Liu, Xiao-Yang Wang, Alassan Maman Bachir, Lin Zhao and Wu-Chun Cao
    Citation: Malaria Journal 2024 23:30
    Content type: Research Published on:

  16. Malaria outbreaks are detected by applying the World Health Organization (WHO)-recommended thresholds (the less sensitive 75th percentile or mean + 2 standard deviations [2SD] for medium-to high-transmission a...

    Authors: Marie Gorreti Zalwango, Jane F. Zalwango, Daniel Kadobera, Lilian Bulage, Carol Nanziri, Richard Migisha, Bosco B. Agaba, Benon Kwesiga, Jimmy Opigo, Alex Riolexus Ario and Julie R. Harris
    Citation: Malaria Journal 2024 23:18
    Content type: Research Published on:

  17. Approximately 32 million pregnant women are at risk of malaria with up to 10,000 maternal deaths and 200,000 neonates at risk annually. Intermittent Preventive Treatment (IPT) with sulfadoxine-pyrimethamine (S...

    Authors: Sabrina Lynda Simo Kamga, Innocent Mbulli Ali, Ghislain Romeo Ngangnang, Mehmet Can Ulucesme, Leonard T. D. Keptcheu, Eva Mai Keming, Valery-Pacome Kom Tchuenkam, Juluis Visnel Foyet, Münir Aktas, Michel Noubom and Vincent K. Payne
    Citation: Malaria Journal 2024 23:6
    Content type: Research Published on:

  18. Malaria is still endemic in South Korea. However, limited information is available on the current Anopheles breeding sites and the occurrence of insecticide resistance-associated genetic mutations and their distr...

    Authors: Hyelee Hong, Tae-Hui Eom, Thuy-Tien Thi Trinh, Bao Duong Tuan, Hyun Park and Seon-Ju Yeo
    Citation: Malaria Journal 2023 22:381
    Content type: Research Published on:

  19. Mass drug administration (MDA) and indoor residual spraying (IRS) are potent malaria burden reduction tools. The impact of combining MDA and IRS is not well documented. We evaluated the impact of MDA + IRS com...

    Authors: Mulebeke Ronald, Wanzira Humphrey, Yeka Adoke and Van Geertruyden Jean-Pierre
    Citation: Malaria Journal 2023 22:378
    Content type: Research Published on:

  20. Plasmodium falciparum genetic diversity can add information on transmission intensity and can be used to track control and elimination interventions.

    Authors: Abeba Gebretsadik Reda, Tiffany Huwe, Cristian Koepfli, Ashenafi Assefa, Sofonias Kifle Tessema, Alebachew Messele, Lemu Golassa and Hassen Mamo
    Citation: Malaria Journal 2023 22:376
    Content type: Research Published on:

  21. In 2020, the Zambia National Malaria Elimination Centre targeted the distribution of long-lasting insecticidal nets (LLINs) and indoor-residual spraying (IRS) campaigns based on sub-district micro-planning, wh...

    Authors: Irene Kyomuhangi, Andrew Andrada, Zhiyuan Mao, Derek Pollard, Christina Riley, Adam Bennett, Busiku Hamainza, Hannah Slater, Justin Millar, John M. Miller, Thomas P. Eisele and Kafula Silumbe
    Citation: Malaria Journal 2023 22:365
    Content type: Research Published on:

  22. Dual hrp2/hrp3 genes deletions in P. falciparum isolates are increasingly reported in malaria-endemic countries and can produce false negative RDT results leading to inadequate case management. Data on the freque...

    Authors: Casimire Wendlamita Tarama, Harouna Soré, Mafama Siribié, Siaka Débé, Réné Kinda, Wendyam Gérard Nonkani, Farida Tiendrebeogo, Winnie Bantango, Kassoum Yira, Esther Yéri Hien, Moussa Wandaogo Guelbéogo, Yves Traoré, Didier Ménard and Adama Gansané
    Citation: Malaria Journal 2023 22:363
    Content type: Research Published on:

  23. Plasmodium vivax is the main species responsible for human malaria in Brazil, and one of its manifestations is splenic malaria, though there are still challenges in its diagnosis. The present study aimed to stand...

    Authors: Raimunda Sandra Pacheco Souza, Monique F. dos Reis, Luiz Carlos de Lima Ferreira, Manuela C. Morais, Antonio Kassio S. Lima, Laila Rowena Albuquerque Barbosa, Gisely Cardoso de Melo and Marcus Vinicius Guimaraes de Lacerda
    Citation: Malaria Journal 2023 22:361
    Content type: Research Published on:

  24. Karnataka is one of the largest states in India and has a wide range of geographical terrains, ecotypes, and prevalence of malaria. It experiences a voluminous influx and efflux of people across the state that...

    Authors: Vani Hanumantappa Chalageri, Shrinivasa B. Marinaik, Sujith N. Nath, Richa Singhal, Smita Rawat, Krishnappa Ravikumar, Mahamood Shariff and Alex Eapen
    Citation: Malaria Journal 2023 22:353
    Content type: Research Published on:

  25. Malaria affects millions of Cameroonian children under 5 years of age living in the North and Far North regions. These regions bear the greatest burden, particularly for children under 5 years of age. To reduc...

    Authors: Arnold Fottsoh Fokam, Toussaint Rouamba, Sekou Samadoulougou, Yazoume Ye and Fati Kirakoya-Samadoulougou
    Citation: Malaria Journal 2023 22:347
    Content type: Research Published on:

  26. The efficacy of chloroquine treatment for vivax malaria has been rarely evaluated due to a lack of an appropriate testing method. The objective of this study was to conduct molecular monitoring of chloroquine ...

    Authors: Hongyun Ding, Ying Dong, Yan Deng, Yanchun Xu, Yan Liu, Jing Wu, Mengni Chen, Canglin Zhang, Li Liu and Yingkun Lin
    Citation: Malaria Journal 2023 22:338
    Content type: Research Published on:

  27. The Lao PDR National Strategic Plan for malaria control and elimination for year 2021–2025 emphasizes the importance of routine entomological surveillance being conducted in areas with high transmission and in...

    Authors: Sébastien Marcombe, Santi Maithaviphet, Rita Reyburn, Khamfong Kunlaya, Khambang Silavong, Bouasy Hongvanthong, Viengxay Vanisaveth, Viengphone Sengsavath, Vilasack Banouvong, Keobouphaphone Chindavongsa, Boualam Khamlome and Matthew Shortus
    Citation: Malaria Journal 2023 22:319
    Content type: Research Published on:

  28. Appropriate malaria treatment-seeking behaviour (TSB) is critical for timely detecting malaria, prompt treatment, and prevention of onward transmission of the disease in a community. This study aimed to compar...

    Authors: Jian-Wei Xu, Dao-Wei Deng, Chun Wei, Xing-Wu Zhou and Jian-Xiong Li
    Citation: Malaria Journal 2023 22:309
    Content type: Research Published on:

  29. Imperfect adherence is a major barrier to effective primaquine radical cure of Plasmodium vivax. This study investigated the effect of reduced adherence on the risk of P. vivax recurrence.

    Authors: Parinaz Mehdipour, Megha Rajasekhar, Saber Dini, Sophie Zaloumis, Tesfay Abreha, Ishag Adam, Ghulam Rahim Awab, J. Kevin Baird, Larissa W. Brasil, Cindy S. Chu, Liwang Cui, André Daher, Margarete do Socorro M Gomes, Lilia Gonzalez‑Ceron, Jimee Hwang, Harin Karunajeewa…
    Citation: Malaria Journal 2023 22:306
    Content type: Research Published on:

  30. Plasmodium vivax malaria is considered a major threat to malaria eradication. The radical cure for P. vivax malaria normally requires a 14-day administration of primaquine (PQ) to clear hypnozoites. However, main...

    Authors: Kyawt Mon Win, Pyae Linn Aung, Zau Ring, Nay Yi Yi Linn, Myat Phone Kyaw, Wang Nguitragool, Liwang Cui, Jetsumon Sattabongkot and Saranath Lawpoolsri
    Citation: Malaria Journal 2023 22:302
    Content type: Research Published on:

  31. Strengthening malaria control activities in Tanzania has dramatically declined human malaria infections. However, there is an increasing epidemiological shift in the burden on school-age children. The underlyi...

    Authors: Fadhila Kihwele, Tegemeo Gavana, Christina Makungu, Hajirani M. Msuya, Yeromin P. Mlacha, Nicodem James Govella, Prosper Pius Chaki and Bruno Fokas Sunguya
    Citation: Malaria Journal 2023 22:293
    Content type: Research Published on:

  32. Larval Source Management (LSM) is an important tool for malaria vector control and is recommended by WHO as a supplementary vector control measure. LSM has contributed in many successful attempts to eliminate ...

    Authors: Andy Hardy, Khamis Haji, Faiza Abbas, Juma Hassan, Abdullah Ali, Yussuf Yussuf, Jackie Cook, Laura Rosu, Arnon Houri-Yafin, Arbel Vigodny, Gregory Oakes, Silas Majambere and Eve Worrall
    Citation: Malaria Journal 2023 22:286
    Content type: Research Published on:

  33. Malaria remains a major public health concern around the world, particularly in resource-constrained countries. Malaria still accounts for 40% of all Out-Patient Department (OPD) cases in Ghana, with children ...

    Authors: Prince Adum, Veronica Adwoa Agyare, Joseph Owusu-Marfo and Yaa Nyarko Agyeman
    Citation: Malaria Journal 2023 22:268
    Content type: Research Published on:

  34. Malaria was once widespread in Guangzhou, China. However, a series of control measures have succeeded in eliminating local malaria infections. Based on the analysis of the characteristics of malaria epidemics ...

    Authors: Yuehua Chen, Hao Zhang, Haiyan Chen, Lirui Fan, Conghui Xu, Jianmin Xu, Shouyi Chen, Kuncai Chen and Yuehong Wei
    Citation: Malaria Journal 2023 22:265
    Content type: Research Published on:

  35. Despite significant efforts made to control malaria in Ethiopia, the disease remains one of the top public health problems in the country. Baseline malaria prevalence and associated factor at high malaria area...

    Authors: Yosef Yohanes Lakew, Anteneh Fikrie, Sisay Bedane Godana, Fatuma Wariyo and Wongelawit Seyoum
    Citation: Malaria Journal 2023 22:259
    Content type: Research Published on:

  36. Malaria remains a major public health concern in The Gambia. The study assessed the trend of malaria admissions and outcome of adult patients admitted after the start of the COVID-19 pandemic in a tertiary hos...

    Authors: Sheikh Omar Bittaye, Abubacarr Jagne, Lamin E. S. Jaiteh, Alfred Amambua-Ngwa, Abdul Karim Sesay, Bertha Ekeh, Behzad Nadjm, Williams Estrada Ramirez, Asmell Ramos, Basil Okeahialam, Emmanuel Effa, Ousman Nyan and Ramou Njie
    Citation: Malaria Journal 2023 22:253
    Content type: Research Published on:

  38. To enhance malaria elimination, Vietnam adopted a Reactive Surveillance and Response (RASR) Strategy in which malaria case notification and investigation must be completed within 2 days followed by a focus inv...

    Authors: Win Han Oo, Xuan Thang Nguyen, Thi Van Anh Ngo, Duc Thang Ngo, Win Htike, Nilar Aye Tun, Kaung Myat Thu, Julia Cutts, T Hong Phuc Nguyen, May Chan Oo, Ei Phyu Htwe, Aung Khine Zaw, Katherine O’Flaherty, Paul A. Agius and Freya J. I. Fowkes
    Citation: Malaria Journal 2023 22:229
    Content type: Research Published on:

  39. Malaria, transmitted by the bite of infective female Anopheles mosquitoes, remains a global public health problem. The presence of invasive Anopheles stephensi, capable of transmitting Plasmodium vivax and Plasmo...

    Authors: Abebe Teshome, Berhanu Erko, Lemu Golassa, Gedeon Yohannes, Seth R. Irish, Sarah Zohdy, Melissa Yoshimizu and Sisay Dugassa
    Citation: Malaria Journal 2023 22:218
    Content type: Research Published on:

  40. Chloroquine (CQ) has been the preferred clinical treatment for vivax malaria in Yunnan Province since 1958, with over 300,000 patients. This study aimed to help make trend predictions regarding variations the ...

    Authors: Hongyun Ding, Ying Dong, Yan Deng, Yanchun Xu, Yan Liu, Jing Wu, Mengni Chen, Canglin Zhang and Weibin Zheng
    Citation: Malaria Journal 2023 22:181
    Content type: Research Published on:

  41. The reliance on blood for thin and thick blood smear microscopy—using a relatively invasive procedure has presented challenges to the use of reliable diagnostic tests in non-clinical settings at the point-of-n...

    Authors: John Diaz, Cody Gusto, Kaci McCoy, Colby Silvert, Joseph A. Bala, Joseph Atibu, Antoinette Tshefu, Melchior Mwandagalirwa and Rhoel R. Dinglasan
    Citation: Malaria Journal 2023 22:180
    Content type: Research Published on:

  42. Pfcrt gene has been associated with chloroquine resistance and the pfmdr1 gene can alter malaria parasite susceptibility to lumefantrine, mefloquine, and chloroquine. In the absence of chloroquine (CQ) and extens...

    Authors: Geletta Tadele, Aminata Jawara, Mary Oboh, Eniyou Oriero, Sisay Dugassa, Alfred Amambua-Ngwa and Lemu Golassa
    Citation: Malaria Journal 2023 22:171
    Content type: Research Published on:

  44. Indoor residual spraying (IRS) has been the main tool used to control malaria. Reducing the life span and the density of the vector mosquitoes are direct effects of IRS towards restricting malaria transmission...

    Authors: Medina Ibrahim, Hunachew Beyene, Alemu Tolcha, Habtamu Eskendir and Abiyu Ayalew Assefa
    Citation: Malaria Journal 2023 22:144
    Content type: Research Published on:

  45. Measuring risk of malaria transmission is complex, especially in case of Plasmodium vivax. This may be overcome using membrane feeding assays in the field where P. vivax is endemic. However, mosquito-feeding assa...

    Authors: Andargie Abate, Jifar Hassen, Laurent Dembele, Didier Menard and Lemu Golassa
    Citation: Malaria Journal 2023 22:136
    Content type: Research Published on:

  47. Malaria remains one of the main causes of morbidity and mortality in Cameroon. To inform vector control intervention decision making, malaria vector surveillance was conducted monthly from October 2018 to Sept...

    Authors: Etienne Fondjo, Jean-Claude Toto, Magellan Tchouakui, Wolfgang Ekoko Eyisap, Salomon Patchoke, Benjamin Menze, Boris Njeambosay, Francis Zeukeug, Raymond Tabue Ngomdjum, Elysée Mandeng, Emmanuel Elanga-Ndille, Edmond Kopya, Jerome Achille Binyang, Cyrille Ndo, Billy Tene-Fossog, Armel Tedjou…
    Citation: Malaria Journal 2023 22:123
    Content type: Research Published on:

  48. SMC was adopted in Nigeria in 2014 and by 2021 was being implemented in 18 states, over four months between June and October by 143000 community drug distributors (CDDs) to a target population of 23million chi...

    Authors: Nnenna Ogbulafor, Perpetua Uhomoibhi, Emmanuel Shekarau, Jamilu Nikau, Chukwu Okoronkwo, Nadia M. L. Fanou, Ibrahima Marietou Mbaye, Jean-Louis Ndiaye, Andre-Marie Tchouatieu, Abena Poku-Awuku, Corinne Merle, Susana Scott, Paul Milligan, Aminu Ali, Hauwa’u Evelyn Yusuf, Stephen Oguche…
    Citation: Malaria Journal 2023 22:120
    Content type: Research Published on:

  49. Malaria remains a major public health concern in Cameroon. Understanding vector distribution and malaria transmission dynamics is of paramount importance for evaluating the performance of control strategies. T...

    Authors: Nelly Armanda Kala Chouakeu, Timoléon Tchuinkam, Roland Bamou, Mabu Maxim Bindamu, Abdou Talipouo, Edmond Kopya, Parfait Awono-Ambene and Christophe Antonio-Nkondjio
    Citation: Malaria Journal 2023 22:116
    Content type: Research Published on:

  50. Malaria remains a main parasitic disease of humans. Although the largest number of cases is reported in the African region, there are still endemic foci in the Americas. Central America reported 36,000 malaria...

    Authors: Gabriela Matamoros, Denis Escobar, Alejandra Pinto, Delmy Serrano, Eliška Ksandrová, Nicole Grimaldi, Gabriel Juárez-Fontecha, Marcela Moncada, Hugo O. Valdivia and Gustavo Fontecha
    Citation: Malaria Journal 2023 22:110
    Content type: Research Published on: