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Epigenetic Biomarkers

Edited by

Dawn L. DeMeo, MD, MPH, Brigham and Women's Hospital/ Harvard Medical School, USA
James M Flanagan, PhD, Imperial College London, UK
Harold Snieder, PhD, University Medical Center Groningen, The Netherlands
Bea Wisman, PhD, University Medical Center Groningen, The Netherlands
Tomasz K Wojdacz, PhD, Pomeranian Medical University, Poland
New Content Item

Epigenetic biomarkers have significantly contributed to improved understanding of the origins and progression of disease. Moreover, increasing evidence shows that epigenetic biomarkers have potential for personalized medicine. However, routine use of epigenetic biomarkers in in-vitro diagnostics (IVD) is lagging behind the discoveries of new biomarkers. In this thematic series of Clinical Epigenetics, we discuss current progress in development of epigenetic biomarkers for clinical use in common complex diseases of ageing and welcome both original research and reviews.

The sections of the collection include:

1. Types of epigenetic biomarkers and readiness for IVD use

  1. DNA methylation as biomarker
  2. Histone modification as biomarker
  3. Upcoming field of circulating free nucleosomes as biomarker


2. Progress towards clinical use of biomarker

  1. Biomarkers of environmental exposures and causality of the biomarker
  2. Disease predisposition biomarkers
  3. Biomarkers used for disease detection
  4. Clinical disease prevention and management: predictive and prognostic
  5. Monitoring of chronic disease


3. Single versus multiple biomarkers and risk scores
4. Major stages of clinical validation of the biomarker
5. Biomarker detection technologies suitable for IVD use and significance of bioinformatics
6. Ethics and regulatory aspects of IVD epigenetic biomarkers

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. Please find out more about our journal and its policies, here. This collection is closed for submissions.

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  1. Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed. However, N6-methyladenosin...

    Authors: Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv and Rong Wang
    Citation: Clinical Epigenetics 2023 15:170
    Content type: Review Published on:

  2. Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We...

    Authors: Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman…
    Citation: Clinical Epigenetics 2023 15:131
    Content type: Research Published on:

  3. As the average age of fatherhood increases worldwide, so too does the need for understanding effects of aging in male germline cells. Molecular change, including epigenomic alterations, may impact offspring. A...

    Authors: Guilherme de Sena Brandine, Kenneth I. Aston, Timothy G. Jenkins and Andrew D. Smith
    Citation: Clinical Epigenetics 2023 15:127
    Content type: Research Published on:

  4. PAX1 gene methylation plays an important role in the development of cervical cancer. However, its prognostic value after radiotherapy for locally advanced cervical cancer is unknown, so this study aimed to invest...

    Authors: Xuanxuan Li, Huan Liu, Xue Zhou, Yangying Zhou, Yu Zhang, Yu-Ligh Liou, Manting Zeng and Hong Zhu
    Citation: Clinical Epigenetics 2023 15:123
    Content type: Research Published on:

  5. Colorectal polyp is known a precursor of colorectal cancer (CRC) that holds an increased risk for progression to CRC. Circulating cell-free DNA (cfDNA) methylation has shown favorable performance in the detect...

    Authors: Qingxiao Fang, Ziming Yuan, Hanqing Hu, Weiyuan Zhang, Guiyu Wang and Xishan Wang
    Citation: Clinical Epigenetics 2023 15:119
    Content type: Research Published on:

  6. Although immune cells are involved in acute coronary syndrome (ACS), few studies have explored the association of incident ACS with the relative immune cell proportions. We aimed to investigate the association...

    Authors: Xian Shi, Minghan Qu, Yi Jiang, Ziwei Zhu, Chengguqiu Dai, Minghui Jiang, Lin Ding, Yu Yan, Chaolong Wang, Xiaomin Zhang, Shanshan Cheng and Xingjie Hao
    Citation: Clinical Epigenetics 2023 15:115
    Content type: Research Published on:

  7. An adverse intrauterine or periconceptional environment, such as hyperglycemia during pregnancy, can affect the DNA methylation pattern both in mothers and their offspring. In this study, we explored the epige...

    Authors: Teresa Linares-Pineda, Nerea Peña-Montero, Nicolás Fragoso-Bargas, Carolina Gutiérrez-Repiso, Fuensanta Lima-Rubio, María Suarez-Arana, Antonio Sánchez-Pozo, Francisco J. Tinahones, María Molina-Vega, María José Picón-César, Christine Sommer and Sonsoles Morcillo
    Citation: Clinical Epigenetics 2023 15:110
    Content type: Research Published on:

  8. DNA methylation has previously been associated with ischemic stroke, but the specific genes and their functional roles in ischemic stroke remain to be determined. Here we aimed to identify differentially methy...

    Authors: Hao Peng, Helena Palma-Gudiel, Carolina Soriano-Tarraga, Jordi Jimenez-Conde, Mingzhi Zhang, Yonghong Zhang and Jinying Zhao
    Citation: Clinical Epigenetics 2023 15:106
    Content type: Research Published on:

  9. Hematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylat...

    Authors: Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost and Wolfgang Wagner
    Citation: Clinical Epigenetics 2023 15:105
    Content type: Brief Report Published on:

    The Correction to this article has been published in Clinical Epigenetics 2023 15:117

  10. The Dutch population-based cervical cancer screening programme (PBS) consists of primary high-risk human papilloma virus (hrHPV) testing with cytology as triage test. In addition to cervical scraping by a gene...

    Authors: J. de Waard, A. Bhattacharya, M. T. de Boer, B. M. van Hemel, M. D. Esajas, K. M. Vermeulen, G. H. de Bock, E. Schuuring and G. B. A. Wisman
    Citation: Clinical Epigenetics 2023 15:103
    Content type: Research Published on:

  11. The majority of these existing prognostic models of head and neck squamous cell carcinoma (HNSCC) have unsatisfactory prediction accuracy since they solely utilize demographic and clinical information. Leverag...

    Authors: Ziang Xu, Xinlei Chen, Xiaomeng Song, Xinxin Kong, Jiajin Chen, Yunjie Song, Maojie Xue, Lin Qiu, Mingzhu Geng, Changyue Xue, Wei Zhang and Ruyang Zhang
    Citation: Clinical Epigenetics 2023 15:97
    Content type: Research Published on:

  12. Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation of CpG islands in the promoter region contributes a great deal to the oncogenesis and progression of several cancers, including g...

    Authors: Nannan Zhang, Xiaoliang Gao, Qiangqiang Yuan, Xin Fu, Pengliang Wang, Fenglin Cai, Hui Liu, Jing Zhang, Han Liang, Yongzhan Nie and Jingyu Deng
    Citation: Clinical Epigenetics 2023 15:77
    Content type: Research Published on:

  13. Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mut...

    Authors: Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho and Keith D. Robertson
    Citation: Clinical Epigenetics 2023 15:71
    Content type: Research Published on:

  14. The detection of peritoneal metastasis (PM) is limited by current imaging tools. In this prospective study, we aimed to evaluate the sensitivity and specificity of peritoneal cell-free DNA (cfDNA) for diagnosi...

    Authors: Zixu Yuan, Wenle Chen, Duo Liu, Qiyuan Qin, William M. Grady, Alessandro Fichera, Huaiming Wang, Ting Hou, Xinze Lv, Chanhe Li, Hui Wang and Jian Cai
    Citation: Clinical Epigenetics 2023 15:65
    Content type: Research Published on:

  15. Lung adenocarcinoma (LUAD) has a high incidence and recurrence rate. N6-methyladenosine (m6A) modification of RNA has become a promising epigenetic marker in tumors. The dysregulation of both RNA m6A levels and m

    Authors: Yili Ping, Jingjuan Huang, Jichao Zhu, Zujun Sun, Anquan Shang, Chen Chen, Wenfang Liu and Dong Li
    Citation: Clinical Epigenetics 2023 15:60
    Content type: Research Published on:

  16. The incidence of colorectal cancer (CRC) has increased in recent years. Identification of accurate tumor markers has become the focus of CRC research. Early and frequent DNA methylation tends to occur in cance...

    Authors: Qin Xiang, Dishu Zhou, Xinni Xiang, Xin Le, Chaoqun Deng, Ran Sun, Chunhong Li, Huayang Pang, Jin He, Zeze Zheng, Jun Tang, Weiyan Peng, Xi Peng, Xiaoqian He, Fan Wu, Jingfu Qiu…
    Citation: Clinical Epigenetics 2023 15:57
    Content type: Research Published on:

  17. DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with ...

    Authors: Jiahui Si, Lu Chen, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Iona Y. Millwood, Robin G. Walters, Ling Yang, Yiping Chen, Huaidong Du, Shixian Feng, Xiaoming Yang, Daniel Avery, Junshi Chen, Zhengming Chen…
    Citation: Clinical Epigenetics 2023 15:52
    Content type: Research Published on:

  18. In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerat...

    Authors: Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith and Subra Kugathasan
    Citation: Clinical Epigenetics 2023 15:50
    Content type: Research Published on:

  19. Advanced maternal age (AMA) has increased in many high-income countries in recent decades. AMA is generally associated with a higher risk of various pregnancy complications, and the underlying molecular mechan...

    Authors: Meng Qin, Wei Chen, Lingyue Hua, Yan Meng, Jing Wang, Hanna Li, Rui Yang, Liying Yan and Jie Qiao
    Citation: Clinical Epigenetics 2023 15:44
    Content type: Research Published on:

  20. Epigenetic modifications are involved in the remodeling of the tumor microenvironment (TME) and the regulation of immune response. Nonetheless, the role of histone H4 methylation (H4M) modification in the TME ...

    Authors: Linyuan Yu, Tao Ji, Wei Liao, Yuyan Xu, Yinghao Fang, Qing Zhu, Jianmin Nie and Dinghua Yang
    Citation: Clinical Epigenetics 2023 15:43
    Content type: Research Published on:

  21. Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. Whil...

    Authors: Ankit Chhoda, Anup Sharma, Bethsebie Sailo, Haoyu Tang, Nensi Ruzgar, Wan Ying Tan, Lee Ying, Rishabh Khatri, Anand Narayanan, Shrikant Mane, Bony De Kumar, Laura D. Wood, Christine Iacobuzio-Donahue, Christopher L. Wolfgang, John W. Kunstman, Ronald R. Salem…
    Citation: Clinical Epigenetics 2023 15:28
    Content type: Research Published on:

  22. Collagen type XII alpha 1 chain (COL12A1) is associated with human cancer progression. Nevertheless, the expression pattern and the function of COL12A1 in intrahepatic cholangiocarcinoma (iCCA) remain unknown....

    Authors: Zengwei Tang, Yuan Yang, Qi Zhang and Tingbo Liang
    Citation: Clinical Epigenetics 2023 15:13
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Epigenetics 2023 15:46

  23. Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be...

    Authors: Jee Yeon Kim, Jaroslav Jelinek, Young Ho Lee, Dae Hyun Kim, Keunsoo Kang, Su Hyun Ryu, Hye Rin Moon, Kwangjo Cho, Seo Hee Rha, Jae Kwan Cha, Jean-Pierre J. Issa and Jei Kim
    Citation: Clinical Epigenetics 2023 15:11
    Content type: Research Published on:

  24. In their attempt to fulfill the wish of having children, women who suffer from fertility issues often undergo assisted reproductive technologies such as ovarian stimulation, which has been associated with adve...

    Authors: Laura Saucedo-Cuevas, Elena Ivanova, Anamaria-Cristina Herta, Felix Krueger, Katy Billooye, Johan Smitz, Gavin Kelsey and Ellen Anckaert
    Citation: Clinical Epigenetics 2023 15:9
    Content type: Research Published on:

  25. Cardiac surgery and cardiopulmonary bypass induce a substantial immune and inflammatory response, the overactivation of which is associated with significant pulmonary, cardiovascular, and neurologic complicati...

    Authors: Matthew A. Fischer, Douglas J. Chapski, Elizabeth Soehalim, Dennis J. Montoya, Tristan Grogan, Matteo Pellegrini, Hua Cai, Richard J. Shemin and Thomas M. Vondriska
    Citation: Clinical Epigenetics 2022 14:195
    Content type: Research Published on:

  26. The variation in multiple sclerosis (MS) disease severity is incompletely explained by genetics, suggesting genetic and environmental interactions are involved. Moreover, the lack of prognostic biomarkers make...

    Authors: Maria Pia Campagna, Alexandre Xavier, Rodney A. Lea, Jim Stankovich, Vicki E. Maltby, Helmut Butzkueven, Jeannette Lechner-Scott, Rodney J. Scott and Vilija G. Jokubaitis
    Citation: Clinical Epigenetics 2022 14:194
    Content type: Research Published on:

  27. Fetal overgrowth “programs” an elevated risk of type 2 diabetes in adulthood. Epigenetic alterations may be a mechanism in programming the vulnerability. We sought to characterize genome-wide alterations in pl...

    Authors: Meng-Nan Yang, Rong Huang, Tao Zheng, Yu Dong, Wen-Juan Wang, Ya-Jie Xu, Vrati Mehra, Guang-Di Zhou, Xin Liu, Hua He, Fang Fang, Fei Li, Jian-Gao Fan, Jun Zhang, Fengxiu Ouyang, Laurent Briollais…
    Citation: Clinical Epigenetics 2022 14:192
    Content type: Research Published on:

  28. Stroke is the leading cause of mortality in China. DNA methylation has essential roles in multiple diseases, but its association with stroke was barely studied. We hereby explored the association between blood...

    Authors: Chunlan Liu, Mengxia Li, Qiming Yin, Yao Fan, Chong Shen and Rongxi Yang
    Citation: Clinical Epigenetics 2022 14:191
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Epigenetics 2023 15:141

  29. BDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown CpG-87 methylation as a successful biomarker for the prediction of non-resp...

    Authors: Hansi Pathak, Anton Borchert, Sara Garaali, Alexandra Burkert and Helge Frieling
    Citation: Clinical Epigenetics 2022 14:187
    Content type: Research Published on:

  30. Nodal mature T-cell lymphomas (nMTCL) comprises a heterogeneous group of rare malignancies with aggressive biological behavior and poor prognosis. Epigenetic phenomena, including mutations in genes that contro...

    Authors: Luís Alberto de Pádua Covas Lage, Hebert Fabrício Culler, Guilherme Carneiro Barreto, Cadiele Oliana Reichert, Débora Levy, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira
    Citation: Clinical Epigenetics 2022 14:180
    Content type: Brief report Published on:

  31. Konzo, a disease characterized by sudden, irreversible spastic paraparesis, affecting up to 10% of the population in some regions of Sub-Saharan Africa during outbreaks, is strongly associated with dietary exp...

    Authors: Kristen Kocher, Surajit Bhattacharya, Matthew S. Bramble, Daniel Okitundu-Luwa, Dieudonne Mumba Ngoyi, Desire Tshala-Katumbay and Eric Vilain
    Citation: Clinical Epigenetics 2022 14:179
    Content type: Brief Report Published on:

  32. DNA methylation (5-mC) is being widely recognized as an alternative in the detection of sequence variants in the diagnosis of some rare neurodevelopmental and imprinting disorders. Identification of alteration...

    Authors: Robin Grolaux, Alexis Hardy, Catharina Olsen, Sonia Van Dooren, Guillaume Smits and Matthieu Defrance
    Citation: Clinical Epigenetics 2022 14:174
    Content type: Research Published on:

  33. Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). How...

    Authors: Mariateresa Casarotto, Valentina Lupato, Giorgio Giurato, Roberto Guerrieri, Sandro Sulfaro, Annamaria Salvati, Elisa D’Angelo, Carlo Furlan, Anna Menegaldo, Lorena Baboci, Barbara Montico, Irene Turturici, Riccardo Dolcetti, Salvatore Romeo, Vittorio Baggio, Stefania Corrado…
    Citation: Clinical Epigenetics 2022 14:171
    Content type: Research Published on:

  34. In recent years, non-alcoholic steatohepatitis (NASH) has become the main cause of hepatocellular carcinoma (HCC). As a means of improving the treatment of NASH-related HCCs based on early detection, this stud...

    Authors: Junko Kuramoto, Eri Arai, Mao Fujimoto, Ying Tian, Yuriko Yamada, Takuya Yotani, Satomi Makiuchi, Noboru Tsuda, Hidenori Ojima, Moto Fukai, Yosuke Seki, Kazunori Kasama, Nobuaki Funahashi, Haruhide Udagawa, Takao Nammo, Kazuki Yasuda…
    Citation: Clinical Epigenetics 2022 14:168
    Content type: Research Published on:

  35. The death rate of lung cancer (LC) ranks first in the world. Changes of DNA methylation in peripheral blood may be related to malignant tumors. It is necessary to explore blood-based biomarkers of methylation ...

    Authors: Yifei Fang, Yunhui Qu, Longtao Ji, Hao Sun, Jiaqi Li, Yutong Zhao, Feifei Liang, Zhi Wang, Jiao Su, Jingjing Liu, Liping Dai and Songyun Ouyang
    Citation: Clinical Epigenetics 2022 14:167
    Content type: Research Published on:

  36. We screened out several hypermethylated solute carrier (SLC) family genes in acute myeloid leukemia by reduced representation bisulfite sequencing. SLC22A3 encodes an organic cation transport protein, which is cr...

    Authors: Yu Gu, Zi-jun Xu, Jing-dong Zhou, Xiang-mei Wen, Ye Jin, Qian Yuan, Pei-hui Xia, Yuan Feng, Lei Yang, Jiang Lin and Jun Qian
    Citation: Clinical Epigenetics 2022 14:162
    Content type: Research Published on:

  37. Smoking and alcohol consumption may compromise health by way of epigenetic modifications. Epigenetic signatures of alcohol and tobacco consumption could provide insights into the reversibility of phenotypic ch...

    Authors: Jonviea D. Chamberlain, Sébastien Nusslé, Laurence Chapatte, Cassandre Kinnaer, Dusan Petrovic, Sylvain Pradervand, Murielle Bochud, Sarah E. Harris, Janie Corley, Simon R. Cox and Semira Gonseth Nusslé
    Citation: Clinical Epigenetics 2022 14:155
    Content type: Research Published on:

  38. Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV te...

    Authors: Chiara Herzog, Karin Sundström, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner…
    Citation: Clinical Epigenetics 2022 14:150
    Content type: Research Published on:

  39. Proline/arginine-rich end leucine-rich repeat protein (PRELP) is a member of the small leucine-rich proteoglycan family of extracellular matrix proteins, which is markedly suppressed in the majority of early-s...

    Authors: Kanto Shozu, Syuzo Kaneko, Norio Shinkai, Ai Dozen, Hirofumi Kosuge, Makoto Nakakido, Hidenori Machino, Ken Takasawa, Ken Asada, Masaaki Komatsu, Kouhei Tsumoto, Shin-Ichi Ohnuma and Ryuji Hamamoto
    Citation: Clinical Epigenetics 2022 14:147
    Content type: Research Published on:

  40. Epigenetic modifications offer compelling evidence of the environmental etiology of complex diseases. Social and biographical conditions, as well as material exposures, all modulate our biology with consequenc...

    Authors: Luca Chiapperino and Francesco Paneni
    Citation: Clinical Epigenetics 2022 14:144
    Content type: Correspondence Published on:

    The Correspondence to this article has been published in Epigenetics Communications 2023 3:4

    The Correspondence to this article has been published in Epigenetics Communications 2023 3:2

  41. Marijuana is the third most commonly used drug in the USA and efforts to legalize it for medical and recreational use are growing. Despite the increase in use, marijuana’s effect on aging remains understudied ...

    Authors: Drew R. Nannini, Yinan Zheng, Brian T. Joyce, Tao Gao, Lei Liu, David R. Jacobs Jr., Pamela Schreiner, Chunyu Liu, Steve Horvath, Ake T. Lu, Kristine Yaffe, Stephen Sidney, Philip Greenland, Donald M. Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:134
    Content type: Research Published on:

  42. 5-Hydroxymethylcytosine (5hmC), an important DNA epigenetic modification, plays a vital role in tumorigenesis, progression and prognosis in many cancers. Diffuse large B cell lymphoma (DLBCL) can involve almos...

    Authors: Ye Shen, Jinping Ou, Bo He, Jinmin Yang, Huihui Liu, Lihong Wang, Bingjie Wang, Liang Gao, Chengqi Yi, Jinying Peng and Xinan Cen
    Citation: Clinical Epigenetics 2022 14:126
    Content type: Research Published on:

  43. The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in ...

    Authors: Natalia Cullell, Carolina Soriano-Tárraga, Cristina Gallego-Fábrega, Jara Cárcel-Márquez, Elena Muiño, Laia Llucià-Carol, Miquel Lledós, Manel Esteller, Manuel Castro de Moura, Joan Montaner, Anna Rosell, Pilar Delgado, Joan Martí-Fábregas, Jerzy Krupinski, Jaume Roquer, Jordi Jiménez-Conde…
    Citation: Clinical Epigenetics 2022 14:124
    Content type: Research Published on:

  44. DNA methylation-regulated genes have been demonstrated as the crucial participants in the occurrence of coronary heart disease (CHD). The machine learning based on DNA methylation-regulated genes has tremendou...

    Authors: Xiaokang Zhang, Chen Wang, Dingdong He, Yating Cheng, Li Yu, Daoxi Qi, Boyu Li and Fang Zheng
    Citation: Clinical Epigenetics 2022 14:122
    Content type: Research Published on:

  45. Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is quite poor. Although low-dose computed to...

    Authors: Peilong Li, Shibiao Liu, Lutao Du, Ghazal Mohseni, Yi Zhang and Chuanxin Wang
    Citation: Clinical Epigenetics 2022 14:118
    Content type: Review Published on:

  46. DNA 5-hydroxymethylcytosine (5hmC) is produced by dynamic 5mC oxidation process contributing to tissue specification, and loss of 5hmC has been reported in multiple cancers including genitourinary cancers. How...

    Authors: Jie Qi, Yue Shi, Yezhen Tan, Qi Zhang, Jianye Zhang, Jilu Wang, Cong Huang and Weimin Ci
    Citation: Clinical Epigenetics 2022 14:117
    Content type: Research Published on:

  47. Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identif...

    Authors: Cora Palanca-Ballester, David Hervas, Maria Villalba, Teresa Valdes-Sanchez, Diana Garcia, Maria Isabel Alcoriza-Balaguer, Marta Benet, Raquel Martinez-Tomas, Andres Briones-Gomez, Jose Galbis-Caravajal, Alfonso Calvo, Oscar Juan, Agustin Lahoz, Enrique Cases and Juan Sandoval
    Citation: Clinical Epigenetics 2022 14:116
    Content type: Brief Report Published on:

  48. Over the past decade, bioethicists, legal scholars and social scientists have started to investigate the potential implications of epigenetic research and technologies on medicine and society. There is growing...

    Authors: Charles Dupras, Terese Knoppers, Nicole Palmour, Elisabeth Beauchamp, Stamatina Liosi, Reiner Siebert, Alison May Berner, Stephan Beck, Ian Charest and Yann Joly
    Citation: Clinical Epigenetics 2022 14:110
    Content type: Research Published on:

  49. DNA methylation in the human genome is established and maintained by DNA methyltransferases (DNMTs). DNMT isoforms show differential expression by cell lineage and during development, but much remains to be el...

    Authors: Chanachai Sae-Lee, Timothy M. Barrow, Elena Colicino, Si Ho Choi, Yoana Rabanal-Ruiz, Daniel Green, Viktor I. Korolchuk, John C. Mathers and Hyang-Min Byun
    Citation: Clinical Epigenetics 2022 14:103
    Content type: Research Published on:

  50. DNA methylation-based GrimAge acceleration (GrimAA) is associated with a wide range of age-related health outcomes including cardiovascular disease. Since DNA methylation is modifiable by external and behavior...

    Authors: Kyeezu Kim, Yinan Zheng, Brian T. Joyce, Hongmei Jiang, Philip Greenland, David R. Jacobs Jr., Kai Zhang, Lei Liu, Norrina B. Allen, John T. Wilkins, Sarah N. Forrester, Donald M. Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:85
    Content type: Research Published on: