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Identifying people with tuberculosis and linking to care: finding the missing millions

Guest editors: Rachael Burke and Finn McQuaid

New Content ItemDespite ongoing efforts, tuberculosis (TB) remains the second leading cause of death from infectious diseases (after COVID-19) and caused 1.6 million deaths in 2021. Of the 10.6 million people estimated to have developed TB in 2021, only 6.4 million of them started treatment and were notified to National TB Programmes - with this treatment gap made even worse by the impact of COVID-19 on TB diagnosis, treatment and care. Research and insights into TB disease diagnosis, incidence and prevalence, as well as advances in implementation of early detection, prevention, treatment and care are important to inform global and public health efforts to ‘Find the missing millions’ and achieve End TB goals. 

To capture advances and global efforts in this multi-disciplinary area, BMC Global and Public Health welcomed papers for our Collection entitled ‘Identifying people with tuberculosis and linking to care: finding the missing millions', guest edited by Dr. Rachael Burke, from the Malawi Liverpool Wellcome Trust, and Dr. Finn McQuaid, from the London School of Hygiene and Tropical Medicine

We welcomed the submission of Research manuscripts of outstanding interest covering the breadth of multi-disciplinary studies and advances in diagnostics, epidemiology, policy, frameworks, and implementation in this area, including:

  ● Case finding and screening for TB
  ● Early detection of TB  
  ● Novel diagnostics (including diagnostic algorithms) to identify people with TB
  ● Linkage of people from diagnosis to TB care 
  ● TB disease outcomes and the impact of screening or new diagnostic strategies on these outcomes
  ● Modeling the impact of screening and other strategies to identify people with TB on TB epidemiology
  ● Economic impact and cost-effectiveness studies
  ● Values and preferences of people accessing TB testing or screening
  ● Effect of crises on TB screening, diagnosis and linkage to care (including COVID-19, conflict, humanitarian emergencies, and other challenging circumstances)

We encouraged work from local, regional and global partnerships and collaboration among scientists from multi-disciplinary fields. We asked that authors be attentive to the use of non-stigmatizing/preferred language in their manuscripts as outlined in the language guide by The Stop TB Partnership. 

Submission deadline: 29 December 2023

  1. Tuberculosis (TB), a leading cause of infectious death, is curable when patients complete a course of multi-drug treatment. Because entry into the TB treatment cascade usually relies on symptomatic individuals...

    Authors: Zolelwa Sifumba, Helgard Claassen, Stephen Olivier, Palwasha Khan, Hloniphile Ngubane, Thokozani Bhengu, Thando Zulu, Mareca Sithole, Dickman Gareta, Mahomed-Yunus S. Moosa, Willem A. Hanekom, Ingrid V. Bassett and Emily B. Wong
    Citation: BMC Global and Public Health 2024 2:30
  2. Current strategies to promptly, effectively, and equitably screen people with tuberculosis (TB) and link them to diagnosis and care are insufficient; new approaches are required to find the millions of people ...

    Authors: Rachel L. Byrne, Tom Wingfield, Emily R. Adams, Sayera Banu, John Samson Bimba, Andrew Codlin, Ana Cubas Atienzar, Tushar Garg, Stephen John, Ricardo Queiroz Gurgel, Melissa Sander, Victor Santana Santos, S. Bertel Squire, Luan Nguyen Quang Vo and Jacob Creswell
    Citation: BMC Global and Public Health 2024 2:33
  3. Community-based active case finding (ACF) for tuberculosis (TB) involves an offer of screening to populations at risk of TB, oftentimes with additional health promotion, community engagement and health service...

    Authors: Peter MacPherson, Kwame Shanaube, Mphatso D. Phiri, Hannah M. Rickman, Katherine C. Horton, Helena R. A. Feasey, Elizabeth L. Corbett, Rachael M. Burke and Molebogeng X. Rangaka
    Citation: BMC Global and Public Health 2024 2:9

    The Author Correction to this article has been published in BMC Global and Public Health 2024 2:14

  4. Tuberculosis (TB) is the leading infectious killer worldwide, with 10.6 million cases and 1.6 million deaths in 2021 alone. One in 5 incident TB cases were attributable to malnutrition, more than double the fr...

    Authors: Madolyn R. Dauphinais, Kobto G. Koura, Prakash Babu Narasimhan, Saurabh Mehta, Julia L. Finkelstein, Scott K. Heysell and Pranay Sinha
    Citation: BMC Global and Public Health 2024 2:4
  5. Despite 30 years as a public health emergency, tuberculosis (TB) remains one of the world’s deadliest diseases. Most deaths are among persons with TB who are not reached with diagnosis and treatment. Thus, tim...

    Authors: Jacob Creswell, Luan Nguyen Quang Vo, Zhi Zhen Qin, Monde Muyoyeta, Marco Tovar, Emily Beth Wong, Shahriar Ahmed, Shibu Vijayan, Stephen John, Rabia Maniar, Toufiq Rahman, Peter MacPherson, Sayera Banu and Andrew James Codlin
    Citation: BMC Global and Public Health 2023 1:30
  6. To reach the millions of people with tuberculosis (TB) undiagnosed each year, there is an important need to provide people-centered screening and testing services. Despite people-centered care being a key pill...

    Authors: Andrew D. Kerkhoff, Nora S. West, Maria del Mar Castro, David Branigan, Devasahayam J. Christopher, Claudia M. Denkinger, Nguyen Viet Nhung, Grant Theron, William Worodria, Charles Yu, Monde Muyoyeta and Adithya Cattamanchi
    Citation: BMC Global and Public Health 2023 1:27
  7. People with subclinical tuberculosis (TB) have microbiological evidence of disease caused by Mycobacterium tuberculosis, but either do not have or do not report TB symptoms. The relationship between human immunod...

    Authors: Naomi Carter, Emily L. Webb, Limakatso Lebina, Kegaugetswe Motsomi, Zama Bosch, Neil A. Martinson and Peter MacPherson
    Citation: BMC Global and Public Health 2023 1:21
  8. Tuberculosis (TB) is a leading cause of death in children, but many cases are never diagnosed. Microbiological diagnosis of pulmonary TB is challenging in young children who cannot spontaneously expectorate sp...

    Authors: Nisreen Khambati, Rinn Song, Emily Lai-Ho MacLean, Mikashmi Kohli, Laura Olbrich and Else Margreet Bijker
    Citation: BMC Global and Public Health 2023 1:18
  9. To better evaluate the cost-effectiveness of active case finding for tuberculosis, a framework for estimating long-term cost and impact is needed. We outline such a framework and highlight the need for consens...

    Authors: David W. Dowdy and Hojoon Sohn
    Citation: BMC Global and Public Health 2023 1:20
  10. Ultra-portable X-ray devices with artificial intelligence (AI) are increasingly used to screen for tuberculosis (TB). Few studies have documented their performance. We aimed to evaluate the performance of ches...

    Authors: Stephen John, Suraj Abdulkarim, Salisu Usman, Md. Toufiq Rahman and Jacob Creswell
    Citation: BMC Global and Public Health 2023 1:17
  11. Reducing malnutrition through food supplementation is a critical component of the WHO End Tuberculosis (TB) strategy. A results-based financing (RBF) initiative in Madhya Pradesh, India—called Mukti—introduced...

    Authors: Embry Howell, Rama Rao Dammala, Pratibha Pandey, Darcy Strouse, Atul Sharma, Neeta Rao, Sudheer Nadipally, Amar Shah, Varsha Rai and Russell Dowling
    Citation: BMC Global and Public Health 2023 1:13