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Advances and challenges in imaging rheumatic & musculoskeletal disorders

Editors: Domenico Albano (IRCCS Istituto Ortopedico Galeazzi) & Francesco Carrubi (University of L'Aquila)
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Read the Editorial written to accompany this Article Collection. 
 

"In recent years, technological improvements allowed imaging modalities to become increasingly essential in achieving early and precise diagnoses in the field of rheumatic and musculoskeletal diseases (RMDs). To date, imaging examinations are routinely used in all steps of diagnostic and therapeutic care pathways of patients affected by RMDs. The articles published in this Article Collection clearly show the efforts of researchers to find innovative applications of musculoskeletal imaging in clinical practice and to face the crucial challenges that remain in the interpretation and quality control of images. Highly performing diagnostic technologies are currently available to early diagnose and accurately monitor several musculoskeletal disorders, but also to guide personalized interventional therapeutic procedures tailored to the individual patients in the emerging process of precision medicine. Among these new modalities, some are particularly promising and thereby subject to several lines of research in RMDs, including SPECT-CT and dual-energy CT, MRI sequences, high and ultra-high frequency ultrasound with effective tools like shear wave elastography." 

This Article Collection was published on 4 March 2021 cross-journal between BMC Musculoskeletal Disorders & BMC Rheumatology.

  1. Facioscapulohumeral muscular dystrophy (FSHD) is a patchy and slowly progressive disease of skeletal muscle. For MRI to be a useful biomarker in an FSHD clinical trial, it should reliably detect changes over r...

    Authors: Leo H. Wang, Dennis W. W. Shaw, Anna Faino, Christopher B. Budech, Leann M. Lewis, Jeffrey Statland, Katy Eichinger, Stephen J. Tapscott, Rabi N. Tawil and Seth D. Friedman

    Citation: BMC Musculoskeletal Disorders 2021 22:262

    Content type: Research article

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  2. To explore the value of magnetic resonance quantitative analysis using diffusion tensor imaging, T2 mapping, and intravoxel incoherent motion in the evaluation of eccentric exercise-induced muscle damage and t...

    Authors: Xiaohong Lyu, Yue Gao, Qiang Liu, Heng Zhao, Huadong Zhou and Shinong Pan

    Citation: BMC Musculoskeletal Disorders 2021 22:239

    Content type: Research article

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  3. In recent years, technological improvements allowed imaging modalities to become increasingly essential in achieving early and precise diagnoses in the field of rheumatic and musculoskeletal diseases (RMDs). T...

    Authors: Domenico Albano and Francesco Carubbi

    Citation: BMC Musculoskeletal Disorders 2021 22:227

    Content type: Editorial

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  4. Real-time ultrasound imaging (RUSI) has been increasingly used as a form of biofeedback when instructing and re-training muscle contraction. However, the effectiveness of the RUSI on a single sustained contrac...

    Authors: Shanshan Lin, Bo Zhu, Yiyi Zheng, Guozhi Huang, Qing Zeng and Chuhuai Wang

    Citation: BMC Musculoskeletal Disorders 2021 22:142

    Content type: Research article

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    The Correction to this article has been published in BMC Musculoskeletal Disorders 2021 22:600

  5. Osteoporotic fractures are a major cause of morbidity in the elderly. Menopausal women represent the population with the highest risk of early osteoporosis onset, often accompanied by vertebral fractures (VF)....

    Authors: Annamaria Zaia, Roberto Rossi, Roberta Galeazzi, Manuela Sallei, Pierluigi Maponi and Pietro Scendoni

    Citation: BMC Musculoskeletal Disorders 2021 22:108

    Content type: Research article

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  6. The intrinsic muscles of the foot are key contributors to foot function and are important to evaluate in lower limb disorders. Magnetic resonance imaging (MRI), provides a non-invasive option to measure muscle...

    Authors: Melinda M. Franettovich Smith, James M. Elliott, Aiman Al-Najjar, Kenneth A. Weber II, Mark A. Hoggarth, Bill Vicenzino, Paul W. Hodges and Natalie J. Collins

    Citation: BMC Musculoskeletal Disorders 2021 22:97

    Content type: Technical advance

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  7. The purpose of the study is to investigate the correlation between upper lumbar disc herniation (ULDH) and multifidus muscle degeneration via the comparison of width, the cross-sectional area and degree of fat...

    Authors: Chong Liu, Jiang Xue, Jingjing Liu, Gang Ma, Abu Moro, Tuo Liang, Haopeng Zeng, Zide Zhang, Guoyong Xu, Zhaojun Lu and Xinli Zhan

    Citation: BMC Musculoskeletal Disorders 2021 22:92

    Content type: Research article

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  8. Facioscapulohumeral muscular dystrophy (FSHD) is a patchy and slowly progressive disease of skeletal muscle. MRI short tau inversion recovery (STIR) sequences of patient muscles often show increased hyperinten...

    Authors: Leo H. Wang, Laura M. Johnstone, Michael Bindschadler, Stephen J. Tapscott and Seth D. Friedman

    Citation: BMC Musculoskeletal Disorders 2021 22:56

    Content type: Case report

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  9. Rheumatoid arthritis (RA) is characterized by systemic inflammation and bone and muscle loss. Recent research showed that obesity facilitates inflammation, but it is unknown if obesity also increases the risk ...

    Authors: Andreas Friedberger, Camille Figueiredo, Tobias Bäuerle, Georg Schett and Klaus Engelke

    Citation: BMC Rheumatology 2020 4:72

    Content type: Research article

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  10. Imaging cannot be performed during natural weightbearing in biomechanical studies using conventional closed-bore MRI, which has necessitated simulating weightbearing load on the joint. Upright, open MRI (UO-MR...

    Authors: Andrew M. Schmidt, David J. Stockton, Michael A. Hunt, Andrew Yung, Bassam A. Masri and David R. Wilson

    Citation: BMC Musculoskeletal Disorders 2020 21:795

    Content type: Technical advance

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  11. The currently available scoring methods for enthesitis are often measures of pain but not of inflammation at entheseal sites. The Outcome Measures in Rheumatology Clinical Trials (OMERACT) psoriatic arthritis ...

    Authors: Xenofon Baraliakos, Philipp Sewerin, Eugenio de Miguel, Effie Pournara, Christine Kleinmond, Annette Wiedon and Frank Behrens

    Citation: BMC Musculoskeletal Disorders 2020 21:767

    Content type: Technical advance

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  12. We developed a fully automatic three-dimensional knee MRI analysis software that can quantify meniscus extrusion and cartilage measurements, including the projected cartilage area ratio (PCAR), which represent...

    Authors: Hayato Aoki, Nobutake Ozeki, Hisako Katano, Akinobu Hyodo, Yugo Miura, Junpei Matsuda, Kimiko Takanashi, Kenji Suzuki, Jun Masumoto, Noriya Okanouchi, Takeo Fujiwara and Ichiro Sekiya

    Citation: BMC Musculoskeletal Disorders 2020 21:742

    Content type: Research article

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  13. The aim of this study is to introduce a new method of percutaneous endoscopic decompression under 3D real-time image-guided navigation for spinal stenosis in degenerative kyphoscoliosis patients without instab...

    Authors: Tsung-Yu Ho, Chung-Wei Lin, Chien-Chun Chang, Hsien-Te Chen, Yen-Jen Chen, Yuan-Shun Lo, Pan-Hsuan Hsiao, Po-Chen Chen, Chih-Sheng Lin and Hsi-Kai Tsou

    Citation: BMC Musculoskeletal Disorders 2020 21:734

    Content type: Technical advance

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  14. Musculoskeletal ultrasound (MSUS) and the multi-biomarker disease activity (MBDA) score are outcome measures that may aid in the management of rheumatoid arthritis (RA) patients. This study evaluated tofacitin...

    Authors: Amir A. Razmjou, Jenny Brook, David Elashoff, Gurjit Kaeley, Soo Choi, Tanaz Kermani and Veena K. Ranganath

    Citation: BMC Rheumatology 2020 4:55

    Content type: Research article

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  15. Gout has been associated with weaker foot/leg muscles and altered gait patterns. There is also evidence of on-going foot pain and an increased risk of tendinopathy, with the Achilles and patella tendons most f...

    Authors: Simon Otter, Catherine Payne, Anna-Marie Jones, Nick Webborn and Peter Watt

    Citation: BMC Musculoskeletal Disorders 2020 21:658

    Content type: Research article

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  16. Kashin–Beck disease (KBD) is a disabling osteoarticular disease involving growth and joint cartilage. Early diagnosis can effectively prevent the progress of the disease. However, the early diagnosis of it is ...

    Authors: Yong Li, Pengde Kang, Zongke Zhou, Fuxing Pei, Qing He and Dike Ruan

    Citation: BMC Musculoskeletal Disorders 2020 21:540

    Content type: Research article

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  17. One of the most significant complications after a femoral neck fracture is osteonecrosis of the femoral head (ONFH). The concomitant use of single-photon emission computed tomography (SPECT) with computed tomo...

    Authors: Jae Youn Yoon, Soong Joon Lee, Kang Sup Yoon and Pil Whan Yoon

    Citation: BMC Musculoskeletal Disorders 2020 21:517

    Content type: Research article

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  18. The traditional Tönnis Classification System has inherent drawbacks as it is vulnerable to the subjectivity of a four-grade system. A two-grade classification could potentially be more reliable. The purpose of...

    Authors: Jacob Shapira, Jeffrey W. Chen, Rishika Bheem, Philip J. Rosinsky, David R. Maldonado, Ajay C. Lall and Benjamin G. Domb

    Citation: BMC Musculoskeletal Disorders 2020 21:502

    Content type: Research article

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  19. The aim of this study was to investigate the feasibility of an individual navigation template for the deep pin position on the iliac crest, based on digital design and 3D printing technology.

    Authors: Bin Liang, Qiang Chen, Shuai Liu, Shuo Chen, Qingqiang Yao, Bo Wei, Yan Xu, Cheng Tang and Liming Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:478

    Content type: Technical advance

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  20. The aim of the present study was to describe and measure the occipital-cervical distance by a novel method utilizing the occiput-C4 distance (OC4D) in normal subjects, as a proposed tool to guide restoration o...

    Authors: Chao Tang, Sheng Yang, Ye Hui Liao, Qiang Tang, Fei Ma, Qing Wang and De Jun Zhong

    Citation: BMC Musculoskeletal Disorders 2020 21:385

    Content type: Research article

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  21. To evaluate the reliability of two different techniques for measuring penetration and distribution of the cement mantle in the proximal tibia after total knee arthroplasty (TKA) with Computer Tomography (CT) i...

    Authors: Hennie Verburg, Linda van Zeeland Koobs, Dieu Donné Niesten, Peter Pilot and Nina Mathijssen

    Citation: BMC Musculoskeletal Disorders 2020 21:374

    Content type: Research article

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  22. Conventional fat quantification methods for rotator cuff muscles have various limitations, such as inconsistent reliabilities of the Goutallier grades and need for advanced techniques in quantitative MRI seque...

    Authors: Dokwan Lee, Ki-Taek Hong, Wonhee Lee, Eun Kyung Khil, Guen Young Lee, Jung-Ah Choi and Yongnam Song

    Citation: BMC Musculoskeletal Disorders 2020 21:362

    Content type: Research article

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  23. In this commentary, we discuss the potential of advanced imaging, particularly Dynamic Contrast Enhanced (DCE) magnetic resonance imaging (MRI) for the objective assessment of the inflammatory process in rheum...

    Authors: Ali Mobasheri, Mark Hinton, Faiq Shaikh and Olga Kubassova

    Citation: BMC Rheumatology 2020 4:33

    Content type: Commentary

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  24. Animal studies have reported an increase in pelvic floor muscle stiffness during pregnancy, which might be a protective process against perineal trauma at delivery. Our main objective is to describe the change...

    Authors: Bertrand Gachon, Xavier Fritel, Fabrice Pierre and Antoine Nordez

    Citation: BMC Musculoskeletal Disorders 2020 21:305

    Content type: Study protocol

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  25. We aimed to determine if composite structural measures of knee osteoarthritis (KOA) progression on magnetic resonance (MR) imaging can predict the radiographic onset of accelerated knee osteoarthritis.

    Authors: Matthew S. Harkey, Julie E. Davis, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Bing Lu, Timothy E. McAlindon and Jeffrey B. Driban

    Citation: BMC Musculoskeletal Disorders 2020 21:299

    Content type: Research article

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  26. Severe spinal pain is an unusual presentation of gout. Due to its rarity and the difficulty of obtaining joint fluid or tissue for crystal analysis, dual energy computed tomography (DECT) may be a useful imagi...

    Authors: Jeremy X. Wang, Beverly Ng, Haesung Bak, David Spencer, Nicholas Manolios and Peter K. K. Wong

    Citation: BMC Rheumatology 2020 4:22

    Content type: Case report

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  27. The purpose of this study was to determine the diagnostic accuracy of ultrasonography for the diagnosis of avulsion fractures of the distal fibula for lateral ankle sprain in children and compare it to that of...

    Authors: Yoshiyuki Takakura, Satoshi Yamaguchi, Ryuichiro Akagi, Makoto Kamegaya, Seiji Kimura, Hirofumi Tanaka and Tetsuro Yasui

    Citation: BMC Musculoskeletal Disorders 2020 21:276

    Content type: Research article

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  28. Shockwave therapy (SWT) is a commonly used intervention for a number of musculoskeletal conditions with varying clinical outcomes. However, the capacity of SWT to influence pathophysiological processes and the...

    Authors: Hani Al-Abbad, Sophie Allen, Susan Morris, Jackie Reznik, Erik Biros, Bruce Paulik and Anthony Wright

    Citation: BMC Musculoskeletal Disorders 2020 21:275

    Content type: Research article

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  29. Various inflammatory conditions may present with musculoskeletal symptoms similar to those of polymyalgia rheumatica (PMR). We investigated findings on 18F-fluorodexoxyglucose (FDG)-positron emission tomography/c...

    Authors: Hideyuki Horikoshi, Takashi Nakanishi, Katsumi Tamura, Fumihiko Kimura and Kenji Itoh

    Citation: BMC Rheumatology 2020 4:21

    Content type: Research article

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  30. Lumbar disc degeneration seen on magnetic resonance imaging (MRI) is defined as loss of signal intensity and/or disc height, alone or in combination with other MRI findings. The MRI findings and thresholds use...

    Authors: Line Dragsbæk, Per Kjaer, Mark Hancock and Tue Secher Jensen

    Citation: BMC Musculoskeletal Disorders 2020 21:253

    Content type: Research article

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  31. A combination of conventional computed tomography and single photon emitted computed tomography (SPECT/CT) provides simultaneous data on the intensity and location of osteoblastic activity. Currently, since SP...

    Authors: Félix Dandois, Stijn De Buck, Lucas Beckers, Darshan Shah, Laura Slane, Hilde Vandenneucker and Lennart Scheys

    Citation: BMC Musculoskeletal Disorders 2020 21:162

    Content type: Technical advance

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  32. MRI scanning has revolutionized the clinical diagnosis of lumbar spinal stenosis (LSS). However, there is currently no consensus as to how best to classify MRI findings which has hampered the development of ro...

    Authors: Yuyu Ishimoto, Amir Jamaludin, Cyrus Cooper, Karen Walker-Bone, Hiroshi Yamada, Hiroshi Hashizume, Hiroyuki Oka, Sakae Tanaka, Noriko Yoshimura, Munehito Yoshida, Jill Urban, Timor Kadir and Jeremy Fairbank

    Citation: BMC Musculoskeletal Disorders 2020 21:158

    Content type: Research article

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  33. Objective: White cord syndrome is extremely rare and search of the literature has revealed very few cases. Postoperative MR scan revealed hyperintense intrinsic cord signal changes within cord ischemia and ede...

    Authors: Deuk Soo Jun, Jong-Min Baik and Seung-Kwan Lee

    Citation: BMC Musculoskeletal Disorders 2020 21:157

    Content type: Case report

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  34. Coracohumeral ligament (CHL) thickening, contracture, and fibroplasia have been identified in glenohumeral idiopathic adhesive capsulitis (GHIAC). The CHL is the main structure responsible for the range of mot...

    Authors: John L. Pape, Mathieu Boudier-Revéret, Jean-Michel Brismée, Kerry K. Gilbert, Detlev Grabs and Stéphane Sobczak

    Citation: BMC Musculoskeletal Disorders 2020 21:136

    Content type: Research article

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  35. Cervical spondylotic myelopathy (CSM) is the most severe type of cervical spondylosis and the most common cause of spinal cord dysfunction among adults over 55 years old. MRI plays an important role in the dia...

    Authors: Nanfang Xu, Youyu Zhang, Guangjin Zhou, Qiang Zhao and Shaobo Wang

    Citation: BMC Musculoskeletal Disorders 2020 21:83

    Content type: Study protocol

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  36. Joint replacements continue to occur during a rheumatoid arthritis (RA) patient’s lifetime despite significant advances in available treatment options. The purpose of this study was to examine and quantify syn...

    Authors: Evan A. Choate, Gurjit S. Kaeley, Jenny Brook, Roy D. Altman, John D. FitzGerald, Astrid R. Floegel-Shetty, David A. Elashoff and Veena K. Ranganath

    Citation: BMC Rheumatology 2020 4:8

    Content type: Research article

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  37. The aim of this study was to evaluate the potential of whole-body CT for diagnosis of hand and forearm fractures in intubated patients with suspected polytrauma.

    Authors: F. Münn, R. A. Laun, A. Asmus, R. Bülow, S. Bakir, L. Haralambiev, A. Eisenschenk and S. Kim

    Citation: BMC Musculoskeletal Disorders 2020 21:49

    Content type: Research article

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  38. Human adipose-derived Mesenchymal stem cells (HADMSCs) have proven their efficacy in treating osteoarthritis (OA), in earlier preclinical and clinical studies. As the tissue repairers are under the control of ...

    Authors: Mohammad Nasb, Huang Liangjiang, Chenzi Gong and Chen Hong

    Citation: BMC Musculoskeletal Disorders 2020 21:33

    Content type: Study protocol

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  39. Bone scintigraphy with 99mTc-labeled diphosphonates can identify prostate cancer bone metastases with high sensitivity, but relatively low specificity, because benign conditions such as osteoarthritis can also tr...

    Authors: Flavian Tabotta, Mario Jreige, Niklaus Schaefer, Fabio Becce, John O. Prior and Marie Nicod Lalonde

    Citation: BMC Musculoskeletal Disorders 2019 20:619

    Content type: Research article

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  40. Superior labral anterior to posterior (SLAP) lesions remain a clinical and diagnostic challenge in routine (non-arthrographic) MR examinations of the shoulder. This study prospectively evaluated the ability of...

    Authors: Felix Wuennemann, Laurent Kintzelé, Felix Zeifang, Michael W. Maier, Iris Burkholder, Marc-André Weber, Hans-Ulrich Kauczor and Christoph Rehnitz

    Citation: BMC Musculoskeletal Disorders 2019 20:598

    Content type: Research article

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