BMC Biology is calling for submissions to our Collection on Lipid metabolism in physiology and cell function.
Lipid metabolism plays a pivotal role in maintaining cellular homeostasis and regulating essential physiological processes. The growing field of lipidomics has provided unprecedented insights into the diverse functions of lipids and their dynamic interplay with cellular processes. Understanding this interplay is crucial. In humans, it has implications in various pathologies such as cancer, obesity, and neurodegenerative disease. In plants, it is essential for proper development and for triggering adaptive stress responses. In addition, lipids are at the forefront of industrial efforts on pharmaceuticals, bioenergetics, food quality, and diverse other applications, and optimization of natural product production in microorganisms could benefit from engineering of lipid metabolic pathways. In light of this, as well as current changes observed in ecosystems and technology development, investigating lipid metabolism in physiology and cell function is not only timely but also essential for advancing disease treatment, therapeutic interventions, crop improvement, and other biotechnological approaches.
The Collection welcomes submissions on the regulators of lipid metabolism, including its genetic determinants and the microbiome, and on the role of lipids in cellular homeostasis and physiological processes, including the regulation of fatty acid metabolism and lipidomics advancements. Additionally, we strongly encourage submissions focusing on the requirements of lipid metabolism and effects of lipid toxicity in diverse organ systems such as the immune and nervous systems, liver, skeletal muscle, and adipose tissue, as well as the basis of lipid metabolism dysregulation in metabolic diseases such as obesity, diabetes, and non-alcoholic fatty liver disease. Research on the interplay between lipid metabolism and cancer progression, inflammation, immune response, aging, neurodegenerative diseases, and lifestyle and therapeutic approaches to targeting lipid metabolism using diverse models of disease are also encouraged. We welcome research on plant lipid metabolism during development and in response to stress, updates on seed oil production and accumulation, and identification of new lipid-derived natural products. Finally, we welcome research on ecosystem adaptation, and biotechnological applications, from animals to plants and microorganisms.
Topics may include, but are not limited to:
- Regulatory mechanisms governing fatty acid synthesis, oxidation, and storage
- Interactions between lipids and other molecular determinants of cell function
- Role of fatty acids in cellular signaling and metabolic homeostasis
- Advancements in lipidomics for lipid profiling and quantification
- Lipotoxicity mechanisms and their contribution to metabolic disorders
- Therapeutic approaches to mitigate lipotoxicity-associated pathologies
- Role of lipid mediators and lipid-derived signaling molecules in inflammation and tissue repair, as well as plant development and adaptation to stress.
- Studies of lipid metabolism in microorganisms of industrial/agricultural interest
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