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Precision Oncology

Precision Oncology

Due to the heterogeneous nature of tumors, molecular profiling is crucial to our understanding of how genomics plays a role in the cause or development of an individual cancer. Such tumor profiles can subsequently be applied to exclusively tailor cancer therapies to directly target a causative mutation for a malignancy, ultimately achieving a personalized and precise approach to cancer treatment. This approach is termed precision oncology.

Precision oncology has made progress in leaps and bounds in recent years and is currently at the heart of revolutionizing cancer research. As this research continues to develop and evolve, the enhanced use of precision oncology in cancer treatment ultimately aims to improve prognosis and outcomes for patients.

We are therefore very proud to present a new cross-journal thematic series focusing on precision oncology. This cross-journal thematic series of original research and review articles gathers the latest research on precision oncology. It focuses on how precision oncology has shaped advances in the impact of non-coding RNAs in epigenetics and cancer, immunotherapy and tumor biology, and the clinical significance of various therapies in a range of cancers. 
 

Participating journals

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  1. Leptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. However, the role of LEPR and its underlying mechanisms in lymphatic metastasis of hepatocarcinoma have not yet been studied.

    Authors: He Huang, Jun Zhang, Fei Ling, Yuhong Huang, Min Yang, Yao Zhang, Yuanyi Wei, Qingqing Zhang, Honghai Wang, Lin Song, Ying Wu, Jiayu Yang and Jianwu Tang
    Citation: Cancer Cell International 2021 21:4
  2. BCD-022 is a trastuzumab biosimilar which was shown to be equivalent to reference trastuzumab in a wide panel of physicochemical studies as well as preclinical studies in vitro and in vivo. International multi...

    Authors: Sergey M. Alexeev, Andrey V. Khorinko, Guzel Z. Mukhametshina, Konstantin G. Shelepen, Olga N. Burdaeva, Sergey A. Kulik, Chiradoni Thugappa Satheesh, Kirti Srivastava, Mummaneni Vikranth, Fedor Kryukov, Anastasia N. Paltusova, Mariya S. Shustova and Roman A. Ivanov
    Citation: BMC Cancer 2020 20:783
  3. Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. The purpose of these methods is to enable functional testing of patient specific efficacy of a...

    Authors: Rami Mäkelä, Antti Arjonen, Ville Härmä, Nina Rintanen, Lauri Paasonen, Tobias Paprotka, Kerstin Rönsch, Teijo Kuopio, Juha Kononen and Juha K. Rantala
    Citation: BMC Cancer 2020 20:590
  4. Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. The purpose of our study was to investig...

    Authors: Lingyun Guo, Zhenjiang Wang, Yuanyuan Du, Jie Mao, Junqiang Zhang, Zeyuan Yu, Jiwu Guo, Jun Zhao, Huinian Zhou, Haitao Wang, Yanmei Gu and Yumin Li
    Citation: Cancer Cell International 2020 20:251
  5. 5-Fluorouracil (5-FU) and capecitabine are fluoropyrimidine derivatives that mainly metabolized with dihydropyrimidine dehydrogenase enzyme (DPD). The genetic polymorphism in the genes encoding this enzyme may...

    Authors: Reza Negarandeh, Ebrahim Salehifar, Fatemeh Saghafi, Hossein Jalali, Ghasem Janbabaei, Mohammad Javad Abdhaghighi and Anahita Nosrati
    Citation: BMC Cancer 2020 20:560
  6. Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular diseases, systemic lupus erythematosus, leukemia, pulm...

    Authors: Zhuo-Zheng Liang, Cheng Guo, Man-Man Zou, Ping Meng and Tian-Tuo Zhang
    Citation: Cancer Cell International 2020 20:173
  7. Anaemia is highly prevalent in gastric cancer (GC) patients. The role of initial haemoglobin levels in predicting the prognosis of GC patients treated by chemotherapy has not been well determined. Our present ...

    Authors: Wen-Huan Li, Ji-Yu Zhang, Wen-Hui Liu and Xian-Xian Chen
    Citation: BMC Cancer 2020 20:414
  8. To identify the spatial patterns of regional lymph node failure of locally advanced hypopharyngeal squamous cell carcinoma (SCC) after first-line treatment with surgery and/or intensity-modulated radiotherapy ...

    Authors: Dongqing Wang, Shui Yu, Limin Zhai, Jin Xu and Baosheng Li
    Citation: BMC Cancer 2020 20:283
  9. Poly (ADP-ribose) polymerase inhibitors targeting BRCA1/2 mutations are available for treating patients with high-grade serous ovarian cancer. These treatments may be more appropriately directed to patients who m...

    Authors: Kyung Jin Eoh, Hye Min Kim, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim and Eun Ji Nam
    Citation: BMC Cancer 2020 20:204
  10. The purpose of this study was to investigate the value of wavelet-transformed radiomic MRI in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) for patients with locally adv...

    Authors: Jiali Zhou, Jinghui Lu, Chen Gao, Jingjing Zeng, Changyu Zhou, Xiaobo Lai, Wenli Cai and Maosheng Xu
    Citation: BMC Cancer 2020 20:100
  11. SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown.

    Authors: Xiaojie Wang, Qian Yu, Waleed M. Ghareeb, Yiyi Zhang, Xingrong Lu, Ying Huang, Shenghui Huang, Yanwu Sun, Jiayi Lin, Jin Liu and Pan Chi
    Citation: BMC Cancer 2019 19:1258
  12. Previous studies have indicated that accompanying socially underserved cancer patients through Patient Navigator (PN) or PN-derived procedures improves therapy management and reassurance. At the Cancer Institu...

    Authors: K. G. Koffi, D. A. Silué, C. Laurent, K. Boidy, S. Koui, G. Compaci, Z. H. Adeba, I. Kamara, R. P. Botty, A. S. Bognini, I. Sanogo, F. Despas and G. Laurent
    Citation: BMC Cancer 2019 19:1247
  13. The aim of this study was to investigate the prognostic significance of the serum γ-glutamyltransferase (γ-GT)-to-prealbumin ratio (GPR) and whether combining this ratio with other parameters can lead to an im...

    Authors: Q. Wang, P. Zhao, N. He, J. P. Sun, K. Li, C. R. Zang, Y. N. Zhao, Y. Zhao and Y. H. Zhang
    Citation: Infectious Agents and Cancer 2019 14:49
  14. Granulocyte-colony stimulating factor (G-CSF) is increasingly been used to prevent febrile neutropenia (FN) associated with the administration of chemotherapy for various cancers. The most common adverse effec...

    Authors: Hideko Hoshina and Hiroyuki Takei
    Citation: BMC Cancer 2019 19:1217
  15. Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association ...

    Authors: Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann and Marianna Kruithof-de Julio
    Citation: BMC Cancer 2019 19:1216
  16. Utilization of RNA sequencing methods to measure gene expression from archival formalin-fixed paraffin-embedded (FFPE) tumor samples in translational research and clinical trials requires reliable interpretati...

    Authors: Michal Marczyk, Chunxiao Fu, Rosanna Lau, Lili Du, Alexander J. Trevarton, Bruno V. Sinn, Rebekah E. Gould, Lajos Pusztai, Christos Hatzis and W. Fraser Symmans
    Citation: BMC Cancer 2019 19:1189
  17. Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) are the two most frequent and well-known oncogene of lung adenocarcinoma. The purpose of this study is to compare the ...

    Authors: Meng Li, Li Zhang, Wei Tang, Jian-Chun Duan, Yu-Jing Jin, Lin-Lin Qi and Ning Wu
    Citation: Cancer Imaging 2019 19:77
  18. Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsucce...

    Authors: Molly J. Carroll, Carl R. Parent, David Page and Pamela K. Kreeger
    Citation: BMC Cancer 2019 19:1025
  19. Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity ...

    Authors: Pablo Fernández-Navarro, Pilar López-Nieva, Elena Piñeiro-Yañez, Gonzalo Carreño-Tarragona, Joaquín Martinez-López, Raúl Sánchez Pérez, Ángel Aroca, Fátima Al-Shahrour, María Ángeles Cobos-Fernández and José Fernández-Piqueras
    Citation: BMC Cancer 2019 19:1005
  20. Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal...

    Authors: Rongrong Zhong, Zhuozhi Chen, Ting Mo, Zimo Li and Peng Zhang
    Citation: Cancer Cell International 2019 19:267
  21. Tumor-infiltrating immune cells (TIICs) are highly relevant to clinical outcome of glioma. However, previous studies cannot account for the diverse functions that make up the immune response in malignant trans...

    Authors: Jiacheng Lu, Hailin Li, Zhengxin Chen, Ligang Fan, Shuang Feng, Xiaomin Cai and Huibo Wang
    Citation: Cancer Cell International 2019 19:265
  22. Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...

    Authors: Jasmine A. McQuerry, David F. Jenkins, Susan E. Yost, Yuqing Zhang, Daniel Schmolze, W. Evan Johnson, Yuan Yuan and Andrea H. Bild
    Citation: BMC Cancer 2019 19:881
  23. Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database of patients with GC who underwent surgical treatment. In this study, we explored the prognostic si...

    Authors: Jingyue Sun, Yao Long, Xin Peng, Desheng Xiao, Jianhua Zhou, Yongguang Tao and Shuang Liu
    Citation: Cancer Cell International 2019 19:225
  24. Cancer is a genetic and epigenetic disease that involves inactivation of tumor suppressor genes and activation of proto-oncogenes. All-trans retinoic acid (ATRA) is an isomer of retinoic acid involved in the o...

    Authors: Lara Lima, Thaísa Cristina Tavares de Melo, Diego Marques, Jéssica Nayara Góes de Araújo, Isabela Samária Fernandes Leite, Camila Xavier Alves, Julieta Genre and Vivian Nogueira Silbiger
    Citation: BMC Cancer 2019 19:866
  25. Renal cell carcinoma (RCC) is not sensitive to conventional radio- and chemotherapies and is at least partially resistant to impairments in cell death-related signaling pathways. The hallmarks of RCC formation...

    Authors: Yongchang Lai, Tao Zeng, Xiongfa Liang, Weizou Wu, Fangling Zhong and Wenqi Wu
    Citation: Cancer Cell International 2019 19:221
  26. The methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) promoter has emerged as a favorable independent prognostic and predictive biomarker in glioma. This study aimed to build a radiomics sig...

    Authors: Ziren Kong, Yusong Lin, Chendan Jiang, Longfei Li, Zehua Liu, Yuekun Wang, Congxin Dai, Delin Liu, Xuying Qin, Yu Wang, Zhenyu Liu, Xin Cheng, Jie Tian and Wenbin Ma
    Citation: Cancer Imaging 2019 19:58
  27. Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germl...

    Authors: Milena Casula, Panagiotis Paliogiannis, Fabrizio Ayala, Vincenzo De Giorgi, Ignazio Stanganelli, Mario Mandalà, Maria Colombino, Antonella Manca, Maria Cristina Sini, Corrado Caracò, Paolo Antonio Ascierto, Rosanna Rita Satta, Amelia Lissia, Antonio Cossu and Giuseppe Palmieri
    Citation: BMC Cancer 2019 19:772
  28. ROS1 rearrangements are validated drivers in lung cancer, which have been identified in a small subset (1–2%) of patients with non-small cell lung cancer (NSCLC). To date, 18 fusion genes of ROS1 have been identi...

    Authors: Shuguang Xu, Wenxian Wang, Chunwei Xu, Xingliang Li, Junhui Ye, Youcai Zhu and Ting Ge
    Citation: BMC Cancer 2019 19:769
  29. The aim of this study was to explore the impact of including or excluding the ischiorectal fossa (IRF) within the clinical target volume during neoadjuvant chemoradiotherapy (NCRT) using intensity modulated ra...

    Authors: Maxiaowei Song, Jianhao Geng, Lin Wang, Yongheng Li, Xianggao Zhu, Xiaofan Li, Lan Mi, Aiwen Wu, Yifan Peng, Yunfeng Yao, Yangzi Zhang, Hongzhi Wang, Chen Shi, Yong Cai and Weihu Wang
    Citation: Radiation Oncology 2019 14:138
  30. Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby
    Citation: Radiation Oncology 2019 14:134
  31. Salivary adenoid cystic carcinoma (SACC) can recur after removal of the primary tumor and treatment, where they can keep no clinical symptoms and dormant state for 10–15 years. NR2F1 has been demonstrated to r...

    Authors: Xiao-lei Gao, Min Zheng, Hao-fan Wang, Lu-ling Dai, Xiang-hua Yu, Xiao Yang, Xin Pang, Li Li, Mei Zhang, Sha-sha Wang, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang
    Citation: BMC Cancer 2019 19:743
  32. MicroRNAs (miRNAs) play a pivotal role in hepatocellular carcinoma (HCC) progression and have been confirmed to participate in the carcinogenesis and development of HCC. However, the relationship between miR-4...

    Authors: Yixi Zhang, Zebin Zhu, Shanzhou Huang, Qiang Zhao, Changjun Huang, Yunhua Tang, Chengjun Sun, Zhiheng Zhang, Linhe Wang, Huadi Chen, Maogen Chen, Weiqiang Ju and Xiaoshun He
    Citation: Cancer Cell International 2019 19:198
  33. Radiomics suffers from feature reproducibility. We studied the variability of radiomics features and the relationship of radiomics features with tumor size and shape to determine guidelines for optimal radiomi...

    Authors: Seung-Hak Lee, Hwan-ho Cho, Ho Yun Lee and Hyunjin Park
    Citation: Cancer Imaging 2019 19:54
  34. Detection of somatic mutations is a mandatory practice for therapeutic definition in precision oncology. However, somatic mutation detection protocols use DNA from formalin-fixed and paraffin-embedded (FFPE) t...

    Authors: C. M. Berra, G. T. Torrezan, C. A. de Paula, R. Hsieh, S. V. Lourenço and D. M. Carraro
    Citation: Applied Cancer Research 2019 39:7
  35. Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, m...

    Authors: Elsa N. Garza Treviño, Paulina Delgado González, Carlos I. Valencia Salgado and Alejandra Martinez Garza
    Citation: Cancer Cell International 2019 19:173
  36. Triple negative breast cancer (TNBC) is a specific subtype of breast cancer with a poor prognosis due to its aggressive biological behaviour and lack of therapeutic targets. We aimed to explore some novel gene...

    Authors: Xuemei Lv, Miao He, Yanyun Zhao, Liwen Zhang, Wenjing Zhu, Longyang Jiang, Yuanyuan Yan, Yue Fan, Hongliang Zhao, Shuqi Zhou, Heyao Ma, Yezhi Sun, Xiang Li, Hong Xu and Minjie Wei
    Citation: Cancer Cell International 2019 19:172
  37. We retrospectively evaluated the capability of radiomic features to predict tumor growth in lung cancer screening and compared the performance of multi-window radiomic features and single window radiomic featu...

    Authors: Hong Lu, Wei Mu, Yoganand Balagurunathan, Jin Qi, Mahmoud A. Abdalah, Alberto L. Garcia, Zhaoxiang Ye, Robert J. Gillies and Matthew B. Schabath
    Citation: Cancer Imaging 2019 19:45
  38. A major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials, patient heterogeneity in response to ther...

    Authors: Erlend Skaga, Evgeny Kulesskiy, Artem Fayzullin, Cecilie J. Sandberg, Swapnil Potdar, Aija Kyttälä, Iver A. Langmoen, Aki Laakso, Emília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo
    Citation: BMC Cancer 2019 19:628
  39. Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments options when th...

    Authors: Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew N. Svalina, Lara E. Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael J. Quist, Kevin L. Matlock, Martin W. Goros, Brian S. Hernandez, Yee C. Doung, Khin Thway…
    Citation: BMC Cancer 2019 19:593
  40. Detection of circulating tumor DNA (ctDNA) is a promising method for postoperative surveillance of lung cancer. However, relatively low positive rate in early stage patients restricts its application. Aberrant...

    Authors: Guannan Kang, Kezhong Chen, Fan Yang, Shannon Chuai, Heng Zhao, Kai Zhang, Bingsi Li, Zhihong Zhang and Jun Wang
    Citation: BMC Cancer 2019 19:579
  41. Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human...

    Authors: Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He and Xinping Cao
    Citation: Cancer Cell International 2019 19:129
  42. Lung adenocarcinoma is the most common type of lung cancers. Whole-genome sequencing studies disclosed the genomic landscape of lung adenocarcinomas. however, it remains unclear if the genetic alternations cou...

    Authors: Jiaxian Yu, Yueming Hu, Yafei Xu, Jue Wang, Jiajie Kuang, Wei Zhang, Jianlin Shao, Dianjing Guo and Yejun Wang
    Citation: BMC Cancer 2019 19:263
  43. To construct a prediction model based on peritumoral radiomics signatures from CT images and investigate its efficiency in predicting early recurrence (ER) of hepatocellular carcinoma (HCC) after curative trea...

    Authors: Quan-yuan Shan, Hang-tong Hu, Shi-ting Feng, Zhen-peng Peng, Shu-ling Chen, Qian Zhou, Xin Li, Xiao-yan Xie, Ming-de Lu, Wei Wang and Ming Kuang
    Citation: Cancer Imaging 2019 19:11
  44. The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs ...

    Authors: Qingmei Wang, Rongzhang He, Tan Tan, Jia Li, Zheng Hu, Weihao Luo, Lili Duan, Wenna Luo and Dixian Luo
    Citation: Cancer Cell International 2019 19:40
  45. Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis.

    Authors: Wei He, Louise Eriksson, Sven Törnberg, Fredrik Strand, Per Hall and Kamila Czene
    Citation: BMC Medicine 2019 17:24
  46. Circulating tumor cells (CTCs) have been described as a population of cells that may seed metastasis, which is a reliable target for the prevention of metastases in lung cancer patients at the early stage. The...

    Authors: Zujun Que, Bin Luo, Zhiyi Zhou, Changsheng Dong, Yi Jiang, Lin Wang, Qihui Shi and Jianhui Tian
    Citation: Cancer Cell International 2019 19:21