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Virtual Slides

Now you can include virtual slides into your article. These will be administered by DiagnomX, scanned and hosted by Huron Technologies International, Inc, Canada, Leica Microsystems, Germany, or Motic Medical Diagnostic Systems, China. The slides will be displayed with an easy to use viewing tool and an individual image data bank for your own use. If you wish to include virtual slides in your manuscript please indicate this in your cover letter on submission, and for an example of a virtual slide please see here.

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  1. Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of me...

    Authors: Fadwa J Altaf, Ghadeer A Mokhtar, Eman Emam, Rana Y Bokhary, Najlaa Bin Mahfouz, Samia Al Amoudi and Zuhoor K AL-Gaithy
    Citation: Diagnostic Pathology 2014 9:139
    Content type: Research Published on:

  2. Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify mismatch repair defective tumors. The tumors typically show uniform and widespread loss of MMR protein stainin...

    Authors: Patrick Joost, Nynke Veurink, Susanne Holck, Louise Klarskov, Anders Bojesen, Maria Harbo, Bo Baldetorp, Eva Rambech and Mef Nilbert
    Citation: Diagnostic Pathology 2014 9:126
    Content type: Research Published on:

  3. Cardiac tumours are relatively rare and are difficult to diagnose merely with imaging techniques. We demonstrated an unusual case of left atrial myxoma, displaying the successful detection by positron emission...

    Authors: Yukio Okazaki, Sohsuke Yamada, Shohei Kitada, Iwao Matsunaga, Eijirou Nogami, Teruo Watanabe, Yasuyuki Sasaguri, Yutaka Honma and Tsuyoshi Itou
    Citation: Diagnostic Pathology 2014 9:117
    Content type: Letter to the Editor Published on:

  4. Cardiac fibrosis disrupts the normal myocardial structure and has a direct impact on heart function and survival. Despite already available digital methods, the pathologist’s visual score is still widely consi...

    Authors: Dainius Daunoravicius, Justinas Besusparis, Edvardas Zurauskas, Aida Laurinaviciene, Daiva Bironaite, Sabine Pankuweit, Benoit Plancoulaine, Paulette Herlin, Julius Bogomolovas, Virginija Grabauskiene and Arvydas Laurinavicius
    Citation: Diagnostic Pathology 2014 9:114
    Content type: Research Published on:

  5. Adult testicular granulosa cell tumors are rare sex cord- stromal tumors of which only 45 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive c...

    Authors: Thomas EO Schubert, Robert Stoehr, Arndt Hartmann, Sabrina Schöne, Mathias Löbelenz and Gregor Mikuz
    Citation: Diagnostic Pathology 2014 9:107
    Content type: Case Report Published on:

  6. The aim of this report is related to adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of the spermatic cord leiomyosarcoma. Primary paratesticular tumors are ...

    Authors: Andrea B Galosi, Marina Scarpelli, Roberta Mazzucchelli, Antonio Lopez-Beltran, Lucio Giustini, Liang Cheng and Rodolfo Montironi
    Citation: Diagnostic Pathology 2014 9:90
    Content type: Short report Published on:

  8. 70–80% of sporadic endometrial carcinomas are defined as endometrioid carcinoma (EC). Early-stage, well differentiated endometrial carcinomas usually retain expression of estrogen and progesterone receptors (E...

    Authors: Hila Kreizman-Shefer, Jana Pricop, Shlomit Goldman, Irit Elmalah and Eliezer Shalev
    Citation: Diagnostic Pathology 2014 9:77
    Content type: Research Published on:

  9. The virtual slide(s) for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​2872096831190851​

    Authors: Noémi Eszes, Lilla Tamási, Attila Csekeő, Judit Csomor, Ágota Szepesi, Gergely Varga, György Balázs, György Losonczy and Veronika Müller
    Citation: Diagnostic Pathology 2014 9:64
    Content type: Case Report Published on:

  10. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an incidence rate of 1 to 2 per million person-years. ACC most commonly arises sporadically, but may be associated with familial tumour syndro...

    Authors: Lukasz Fulawka, Dariusz Patrzalek and Agnieszka Halon
    Citation: Diagnostic Pathology 2014 9:51
    Content type: Case Report Published on:

  11. Hamartin (TSC1) and tuberin (TSC2), encoded by the tuberous sclerosis complex (TSC) genes, form a tumor-suppressor heterodimer which is implicated in PI3K-Akt signaling and acts as a functional inhibitor of the m...

    Authors: Angela Fuchs, Katharina König, Lukas C Heukamp, Jana Fassunke, Jutta Kirfel, Sebastian Huss, Albert J Becker, Reinhard Büttner and Michael Majores
    Citation: Diagnostic Pathology 2014 9:48
    Content type: Research Published on:

  12. Diffuse panbronchiolitis (DPB) is an idiopathic inflammatory disease that seems to have an immunological pathogenesis and that causes a severe progressive suppurative and obstructive respiratory disorder. Comm...

    Authors: Alessandro Ginori, Aurora Barone, David Bennett, Marie Aimée Gloria Munezero Butorano, Maria Grazia Mastrogiulio, Antonella Fossi, Paola Rottoli and Donatella Spina
    Citation: Diagnostic Pathology 2014 9:12
    Content type: Case Report Published on:

  13. Intraductal tubulopapillary neoplasms of the pancreas are very rare tumors characterized by intraductal tubulopapillary growth, ductal differentiation, scant intracellular mucin production and cellular dysplas...

    Authors: Maria Gabriele Ahls, Marco Niedergethmann, Dietmar Dinter, Christian Sauer, Jutta Lüttges, Stefan Post, Alexander Marx and Timo Gaiser
    Citation: Diagnostic Pathology 2014 9:11
    Content type: Case Report Published on:

  14. Protein arginine methyltransferase-5 (PRMT5) is a chromatin-modifying enzyme capable of methylating histone and non-histone proteins, and is involved in a wide range of cellular processes that range from trans...

    Authors: Konstantin Shilo, Xin Wu, Smita Sharma, Meng Welliver, Wenrui Duan, Miguel Villalona-Calero, Junya Fukuoka, Said Sif, Robert Baiocchi, Charles L Hitchcock, Weiqiang Zhao and Gregory A Otterson
    Citation: Diagnostic Pathology 2013 8:201
    Content type: Research Published on:

  15. A 48-year old woman presented with chronic back pain. Previous examinations had been inconclusive. Gynaecological examination revealed large cystic masses on the fundus uteri and left adnexa. Laparoscopy and h...

    Authors: Andreas H Scheel, Josef Frasunek, Werner Meyer and Philipp Ströbel
    Citation: Diagnostic Pathology 2013 8:196
    Content type: Case Report Published on:

  16. Endometriosis is a clinical entity characterized by the presence of normal endometrial mucosa abnormally implanted in locations other than the uterine cavity. Endometriosis can be either endopelvic or extrapel...

    Authors: Nikolaos Machairiotis, Aikaterini Stylianaki, Georgios Dryllis, Paul Zarogoulidis, Paraskevi Kouroutou, Nikolaos Tsiamis, Nikolaos Katsikogiannis, Eirini Sarika, Nikolaos Courcoutsakis, Theodora Tsiouda, Andreas Gschwendtner, Konstantinos Zarogoulidis, Leonidas Sakkas, Aggeliki Baliaka and Christodoulos Machairiotis
    Citation: Diagnostic Pathology 2013 8:194
    Content type: Review Published on:

  18. Hyperplastic polyps (HP) and sessile serrated adenomas (SSA) share morphological similarities. In this immunohistochemical study we chose a panel of potential relevant and promising biomarkers including α-meth...

    Authors: Nimet Dayi, Hideo A Baba, Kurt W Schmid and Klaus J Schmitz
    Citation: Diagnostic Pathology 2013 8:178
    Content type: Research Published on:

  19. Ectopic pancreas in the mediastinum is extremely rare. We are reporting on a case of a twenty two year old woman who presented to our clinic with a large cervical mass. The CT scan revealed a cystic lesion in ...

    Authors: Ariel Rokach, Gabriel Izbicki, Maher Deeb, Naama Bogot, Nissim Arish, Irith Hadas-Halperen, Hava Azulai, Abraham Bohadana and Eli Golomb
    Citation: Diagnostic Pathology 2013 8:176
    Content type: Case Report Published on:

  20. Intravascular papillary endothelial hyperplasia (IPEH) is a benign intravascular process with features mimicking other benign and malignant vascular proliferations. IPEH lesions predominate in the head-neck re...

    Authors: Noyan Can Akdur, Melahat Donmez, Serap Gozel, Huseyin Ustun and Sema Hucumenoglu
    Citation: Diagnostic Pathology 2013 8:167
    Content type: Research Published on:

  21. Very recently, Requena et al. have demonstrated the detailed clinicopathological features of 9 cases of a benign cutaneous plexiform nerve sheath tumor with hybrid characteristics of perineurioma and cellular neu...

    Authors: Sohsuke Yamada, Shohei Kitada, Atsunori Nabeshima, Hirotsugu Noguchi, Yasuyuki Sasaguri and Masanori Hisaoka
    Citation: Diagnostic Pathology 2013 8:165
    Content type: Letter to the Editor Published on:

  22. Tumors that arise in the temporal lobes of infants and spread to the neural system are limited to several diagnoses. Herein, we present an infantile case of a temporal tumor showing neuronal and glial differen...

    Authors: Hirohito Yano, Chiemi Saigoh, Noriyuki Nakayama, Yoshinobu Hirose, Masato Abe, Naoyuki Ohe, Michio Ozeki, Jun Shinoda and Toru Iwama
    Citation: Diagnostic Pathology 2013 8:164
    Content type: Case Report Published on:

  23. A 34-year-old female, with a history of continued asbestos exposure, presented with a papillary peritoneal mesothelioma with a diffuse, prominent clear foamy cell change, with microvacuolation in its papillary...

    Authors: Simona Stolnicu, Enoe Quiñonez, Monica Boros, Claudiu Molnar, Isabel Dulcey and Francisco F Nogales
    Citation: Diagnostic Pathology 2013 8:162
    Content type: Case Report Published on:

  24. A 36-year-old female was hospitalized with symptoms suggesting intestinal occlusion. She was diagnosed with adenocarcinoma of the ampulla of Vater (pT4N0 stage) and underwent cephalic duodenopancreatectomy 8 m...

    Authors: Simona Gurzu, Ioan Jung, Maria Comsulea, Zoltan Kadar, Leonard Azamfirei and Calin Molnar
    Citation: Diagnostic Pathology 2013 8:150
    Content type: Case Report Published on:

  25. Imaging appearance of cyst-like changes is most frequently described in primary neuroendocrine lesions, especially pancreatic NETs.

    Authors: Stefano Fiori, Alessandro Del Gobbo, Gabriella Gaudioso, Lucio Caccamo, Sara Massironi, Federica Cavalcoli, Silvano Bosari and Stefano Ferrero
    Citation: Diagnostic Pathology 2013 8:148
    Content type: Case Report Published on:

  26. Intestinal differentiation in the endometrium is rare with only case reports in the international literature. We describe a case of simultaneous endocervical and intestinal-type mucinous differentiation with g...

    Authors: Rebecca Buell-Gutbrod, C James Sung, W Dwayne Lawrence and M Ruhul Quddus
    Citation: Diagnostic Pathology 2013 8:128
    Content type: Case Report Published on:

  27. The “proximal-type” epithelioid sarcoma is a very rare kind of mesenchimal tumor characterized by the difficulty in histological diagnosis and the very aggressive biological behavior.

    Authors: Lodovico Patrizi, Giacomo Corrado, Maria Saltari, Letizia Perracchio, Chiara Scelzo, Emilio Piccione and Enrico Vizza
    Citation: Diagnostic Pathology 2013 8:122
    Content type: Case Report Published on:

  28. Lymphomas account for less than 5% of thyroid malignant lesions. Vast majority of them are B-cell non-Hodgkin lymphomas (NHL), while Hodgkin lymphoma (HL) is extremely rare. Here we present two cases of HL, at...

    Authors: Ewelina Szczepanek-Parulska, Malgorzata Szkudlarek, Przemyslaw Majewski, Jan Breborowicz and Marek Ruchala
    Citation: Diagnostic Pathology 2013 8:116
    Content type: Case Report Published on:

  29. The chromatin remodeler DAXX, a predominantly nuclear protein, regulates the status of chromatin organization. The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in h...

    Authors: Antonio Zizzi, Maria Alessandra Montironi, Roberta Mazzucchelli, Marina Scarpelli, Antonio Lopez-Beltran, Liang Cheng, Nicola Paone, Paolo Castellini and Rodolfo Montironi
    Citation: Diagnostic Pathology 2013 8:111
    Content type: Research Published on:

  30. Hypoplastic coronary artery disease is a rare condition that may lead to myocardial infarction and sudden death. Here we describe for the first time an isolated hypoplasia of the left circumflex artery (LCX). ...

    Authors: Florian-Nikolaus Riede, Stefan Bulla, Sebastian Grundmann, Martin Werner, Urs-Nikolaus Riede and Claudia Otto
    Citation: Diagnostic Pathology 2013 8:91
    Content type: Case Report Published on:

  31. With varied immunohistochemistry scoring criteria and patient cohorts, HER2-positivity rates in gastric cancer (GC) and gastroesophageal junction (GEJ) adenocarcinoma have been reported with a wide range. Rece...

    Authors: Ling Shan, Jianming Ying and Ning Lu
    Citation: Diagnostic Pathology 2013 8:76
    Content type: Research Published on:

  32. A mammary nodular lesion was recognized one month before the surgery in the right upper breast of a 55-year-old female. The fine needle aspiration cytology specimens contained many individual bizarre, multi-nu...

    Authors: Sohsuke Yamada, Atsunori Nabeshima, Yoshika Nagata, Takashi Tasaki, Hirotsugu Noguchi, Shohei Kitada, Satoshi Kimura, Ke-Yong Wang, Shohei Shimajiri and Yasuyuki Sasaguri
    Citation: Diagnostic Pathology 2013 8:75
    Content type: Case Report Published on:

  33. Primary angiosarcoma of the breast is extremely rare. Radiologic findings are often non specific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor ...

    Authors: Amal Bennani, Layla Chbani, Meryem Lamchahab, Mouhcine Wahbi, Fatimazzahra Fdili Alaoui, Ikram Badioui, Moulay Abdelilah Melhouf and Affaf Amarti
    Citation: Diagnostic Pathology 2013 8:66
    Content type: Case Report Published on:

  34. The comparative study of the results of various segmentation methods for the digital images of the follicular lymphoma cancer tissue section is described in this paper. The sensitivity and specificity and some...

    Authors: Anna Korzynska, Lukasz Roszkowiak, Carlos Lopez, Ramon Bosch, Lukasz Witkowski and Marylene Lejeune
    Citation: Diagnostic Pathology 2013 8:48
    Content type: Research Published on:

  37. Primary leiomyosarcomas of the thyroid gland are extremely rare. we report a case of a 72 year-old women with a painful growing mass of the left neck with skin fistula. The patient underwent a lobectomy. The t...

    Authors: Bennani Amal, Hinde El Fatemi, Ihsane Souaf, Kaouthar Moumna and Amarti Affaf
    Citation: Diagnostic Pathology 2013 8:36
    Content type: Case Report Published on:

  38. We investigated the immunohistochemical expression of p53, MAPK, topoisomerase II alpha (topoII alpha) and Ki67 in ovarian serous carcinomas (OSCs) along with mutational analysis for KRAS and BRAF.

    Authors: Dinka Sundov, Ana Caric, Ivana Mrklic, Dijana Gugic, Vesna Capkun, Irena Drmic Hofman, Branka Petric Mise and Snjezana Tomic
    Citation: Diagnostic Pathology 2013 8:21
    Content type: Research Published on:

  39. Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case...

    Authors: Merieme Ghaouti, Kaoutar Znati, Ahmed Jahid, Fouad Zouaidia, Zakiya Bernoussi, Youssef El Fakir and Najat Mahassini
    Citation: Diagnostic Pathology 2013 8:4
    Content type: Case Report Published on:

  40. A 7-year-old boy with no history of malnutrition or diarrhoea complained of acute abdominal pain, was diagnosed with acute appendicitis, and underwent appendectomy. Histologically, a diffuse infiltrate of larg...

    Authors: Yoshifumi Matsushita and Morishige Takeshita
    Citation: Diagnostic Pathology 2013 8:2
    Content type: Case Report Published on:

  41. Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1–0.2% of all prostatic cancers. Detailed characteristics of the tumor are still unclear due to its rarity.

    Authors: Hitoshi Yamazaki, Teppei Ohyama, Toshiki Tsuboi, Yoshinori Taoka, Dai Kohguchi, Hiroyoshi Iguchi and Teruaki Ao
    Citation: Diagnostic Pathology 2012 7:173
    Content type: Case Report Published on:

  42. Lung cancer most often presents as an inoperable tumour and the diagnosis is usually performed on a small biopsy/cytology specimen. In the group of non small cell lung cancer - not otherwise specified, adenoca...

    Authors: Renata Beljan Perak, Merica Glavina Durdov, Vesna Capkun, Veljka Ivcevic, Antonia Pavlovic, Violeta Soljic and Mari Peric
    Citation: Diagnostic Pathology 2012 7:165
    Content type: Research Published on:

  43. Mixed adenoneuroendocrine carcinoma (MANEC) carcinomas rarely occur in the gallbladder. Here we reported a case of giant gallbladder unresectable mass with local liver invasion and omentum metastasis, which pr...

    Authors: Wu Song, Wenfang Chen, Sheng Zhang, Jianjun Peng and Yulong He
    Citation: Diagnostic Pathology 2012 7:163
    Content type: Case Report Published on:

  44. The ability to distinguish hepatocellular carcinoma (HCC) from metastatic carcinoma (MC) involving the liver and cholangiocarcinoma (CC) by immunohistochemistry has been limited by the lack of a reliable posit...

    Authors: Nehal A Radwan and Naglaa S Ahmed
    Citation: Diagnostic Pathology 2012 7:149
    Content type: Research Published on:

  45. Lung cancer is the leading cause of death among malignant diseases in humans worldwide. In the last decade development of new targeted drugs for the treatment of non-small cell lung cancer proved to be a promi...

    Authors: Claudia Otto, Agnes Csanadi, Paul Fisch, Martin Werner and Gian Kayser
    Citation: Diagnostic Pathology 2012 7:146
    Content type: Short report Published on:

  46. A 67-year-old Japanese female was followed up due to prolonged idiopathic thrombocytopenia with non-response to steroid therapy for 4 years, but recent progressive pancytopenia, hypo-albuminemia, and hypo-γ-gl...

    Authors: Sohsuke Yamada, Takashi Tasakil, Naoko Satoh, Atsunori Nabeshima, Shohei Kitada, Hirotsugu Noguchi, Kozue Yamada, Morishige Takeshita and Yasuyuki Sasaguri
    Citation: Diagnostic Pathology 2012 7:143
    Content type: Case Report Published on:

  48. CD20-positive T-cell lymphoma is extremely rare and only two cases of CD20-positive NK/T-cell lymphoma with aggressive clinical courses have been described in the literature. We present a case of unusual NK/T-...

    Authors: Qing-ping Jiang, Shao-yan Liu, Yue-xin Yang, Xue-xian Tan, Juan Peng, Zhong-tang Xiong and Zhi Li
    Citation: Diagnostic Pathology 2012 7:133
    Content type: Case Report Published on:

  49. Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of lim...

    Authors: Nawal Hammas, Chbani Laila, Alaoui Lamrani My Youssef, El Fatemi Hind, Taoufiq Harmouch, Tizniti Siham and Amarti Afaf
    Citation: Diagnostic Pathology 2012 7:130
    Content type: Research Published on:

  50. Langerhans cell sarcoma is a rare and aggressive high grade hematopoietic neoplasm with a dismal prognosis. It has a unique morphological and immunotypic profile with a CD1a/ langerin/S100 + phenotype. T cell ...

    Authors: Zhaodong Xu, Ruth Padmore, Carolyn Faught, Lisa Duffet and Bruce F Burns
    Citation: Diagnostic Pathology 2012 7:128
    Content type: Case Report Published on: