Clinical Trials Day

Clinical Trials Day, celebrated on May 20th, is an opportunity to recognize and show appreciation to clinical research professionals for their efforts in improving public health.

Join us in celebrating Clinical Trials Day 2023 with blogs, featured articles, and collections from BMC Trials.

If you are interested in publishing clinical trials research, please consider submitting your manuscript to the latest collection in our Trials journal: Case studies of experience with interim data and IDMCs in RCTs.

Clinical Trials Research

Does reading a book in bed make a difference to sleep in comparison to not reading a book in bed? The People’s Trial—an online, pragmatic, randomised trial

Protocol for ICiCLe-ALL-14 (InPOG-ALL-15-01): a prospective, risk stratified, randomised, multicentre, open label, controlled therapeutic trial for newly diagnosed childhood acute lymphoblastic leukaemia in India

Implementation of an evidence-based management algorithm for patients with chronic pancreatitis (COMBO trial): study protocol for a stepped-wedge cluster-randomized controlled trial

The effect of COVID rehabilitation for ongoing symptoms Post HOSPitalisation with COVID-19 (PHOSP-R): protocol for a randomised parallel group controlled trial on behalf of the PHOSP consortium

The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial

Trial Forge Guidance 3: randomised trials and how to recruit and retain individuals from ethnic minority groups—practical guidance to support better practice

The SPIRIT Checklist—lessons from the experience of SPIRIT protocol editors

Estimands in published protocols of randomised trials: urgent improvement needed

Improving peer review of systematic reviews by involving librarians and information specialists: protocol for a randomized controlled trial

Applying mixed methods to pilot feasibility studies to inform intervention trials

Acceptance and Commitment Therapy to support medication decision-making and quality of life in women with breast cancer: protocol for a pilot randomised controlled trial

A snapshot of consumer engagement in clinical trials in Australia: results of a national survey of clinical trial networks and research organisations

Challenges and adaptations to public involvement with marginalised groups during the COVID-19 pandemic: commentary with illustrative case studies in the context of patient safety research

Identifying potential barriers and solutions to patient partner compensation (payment) in research

The experience of patient partners in research: a qualitative systematic review and thematic synthesis

Featured Blogs

International Clinical Trials Methodology Conference (ICTMC) 2022

In this blog for Clinical Trials Day 2023, Claire Veryard (Programme Manager for the ISRCTN registry) shares some highlights and learning from the International Clinical Trials Methodology Conference (ICTMC) held in October 2022.

Clinical Trials Day 2023: what about the trial participant?

copyright NHS Health Research Authority

In this blog for Clinical Trials Day 2023, Derek C Stewart OBE, a non-executive director at the ISRCTN registry, discusses the importance of patient and public involvement in clinical trials.

Structured reporting of study protocols

In this blog for Clinical Trials Day 2022, we reflect on the Trials journal Structured Study Protocol Template project since its launch in 2019.

COVID-19 structured summaries: rapid publication of randomised trial protocols in BMC Trials

In response to the COVID-19 pandemic, rapid sharing of information about planned clinical trials investigating treatments and vaccines was necessary. In this blog for Clinical Trials Day 2021, we look at the novel reporting of study protocols of COVID-19 randomised trials through the BMC Trials structured summary project over the past year.

Welcoming Submissions

Call for papers: Case studies of experience with interim data and IDMCs in RCTs

Trials invites submission of manuscripts setting out examples of interim (and final) data and the decisions that were made, and of reactions to IDMC recommendations. IDMC members are not co-authors on trial results papers or protocol papers because this compromises their independence; however, co-authorship would be encouraged for these manuscripts to ensure that insight is captured from all parties. If necessary, Trials could explore how to blind individual trials where sharing lessons could be problematic. These case studies would be intended as Commentaries.

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